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LAPTM5 lysosomal protein transmembrane 5 [ Homo sapiens (human) ]

Gene ID: 7805, updated on 2-Nov-2024

Summary

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Official Symbol
LAPTM5provided by HGNC
Official Full Name
lysosomal protein transmembrane 5provided by HGNC
Primary source
HGNC:HGNC:29612
See related
Ensembl:ENSG00000162511 MIM:601476; AllianceGenome:HGNC:29612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLAST6
Summary
This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]
Expression
Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues See more
Orthologs
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Genomic context

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See LAPTM5 in Genome Data Viewer
Location:
1p35.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (30732469..30757774, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (30584986..30610292, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (31205316..31230621, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903888 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 559 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31191909-31192484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 615 Neighboring gene matrilin 1 Neighboring gene MATN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 617 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31205119-31205624 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31205625-31206130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31206171-31206672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31212057-31212616 Neighboring gene uncharacterized LOC105378620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 618 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 621 Neighboring gene microRNA 4420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 622 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31223351-31223894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31223895-31224436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31229428-31230224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 632 Neighboring gene Sharpr-MPRA regulatory region 12480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31246183-31246683 Neighboring gene uncharacterized LOC105378621 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4289 Neighboring gene CRISPRi-validated cis-regulatory element chr1.4291 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:31260718-31261230 Neighboring gene Sharpr-MPRA regulatory region 4114 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:31277163-31277830 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:31277831-31278496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:31282779-31283279 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31291425-31291931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:31296724-31297226 Neighboring gene long intergenic non-protein coding RNA 1778

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy. Li T, et al. Aging (Albany NY), 2022 Feb 14. PMID 35157609, Free PMC Article
  2. Down-regulation of LAPTM5 in human cancer cells. Nuylan M, et al. Oncotarget, 2016 May 10. PMID 27058622, Free PMC Article
  3. Ectopic overexpression of LAPTM5 results in lysosomal targeting and induces Mcl-1 down-regulation, Bak activation, and mitochondria-dependent apoptosis in human HeLa cells. Jun DY, et al. PLoS One, 2017. PMID 28464033, Free PMC Article
  4. Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. Hayami Y, et al. Leukemia, 2003 Aug. PMID 12886255
  5. Stage-specific expression of Clast6/E3/LAPTM5 during B cell differentiation: elevated expression in human B lymphomas. Seimiya M, et al. Int J Oncol, 2003 Feb. PMID 12527926

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function and mechanism of LAPTM5 in diseases.
    Title: The function and mechanism of LAPTM5 in diseases.
  2. ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.
    Title: ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote metastasis in pancreatic ductal adenocarcinoma.
  3. Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.
    Title: Genome-Scale CRISPR screen identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma.
  4. LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/betacatenin pathway.
    Title: LAPTM5 regulated by FOXP3 promotes the malignant phenotypes of breast cancer through activating the Wnt/β‑catenin pathway.
  5. LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.
    Title: LAPTM5 mediates immature B cell apoptosis and B cell tolerance by regulating the WWP2-PTEN-AKT pathway.
  6. Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
    Title: Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
  7. LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr.
    Title: LAPTM5 Restricts HIV-1 Infection in Dendritic Cells and Is Counteracted by Vpr.
  8. Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy.
    Title: Comprehensive bioinformatics analysis identifies LAPTM5 as a potential blood biomarker for hypertensive patients with left ventricular hypertrophy.
  9. Spinespecific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptorpositive breast cancer by activating glutaminedependent mTOR signaling.
    Title: Spine‑specific downregulation of LAPTM5 expression promotes the progression and spinal metastasis of estrogen receptor‑positive breast cancer by activating glutamine‑dependent mTOR signaling.
  10. LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival.
    Title: LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of lysosomal protein transmembrane 5 (LAPTM5) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ61683, FLJ97251, MGC125860, MGC125861

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to lysosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to tumor cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in induction of programmed cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of B cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of autophagic cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-2 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cytokine production involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of interleukin-12 production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of lysosomal membrane permeability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of macrophage cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of receptor catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein targeting to lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lysosomal-associated transmembrane protein 5
Names
CD40-ligand-activated specific transcripts
human retinoic acid-inducible E3 protein
lysosomal associated multispanning membrane protein 5
lysosomal multispanning membrane protein 5
lysosomal-associated multitransmembrane protein 5
retinoic acid-inducible E3 protein

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006762.3 → NP_006753.1  lysosomal-associated transmembrane protein 5

    See identical proteins and their annotated locations for NP_006753.1

    Status: REVIEWED

    Source sequence(s)
    AL137857, BC106897, D42042
    Consensus CDS
    CCDS337.1
    UniProtKB/Swiss-Prot
    Q13240, Q13571, Q14698, Q3KP54
    UniProtKB/TrEMBL
    B4DLI5, D3DPN1, Q5TBB8
    Related
    ENSP00000294507.3, ENST00000294507.4
    Conserved Domains (1) summary
    pfam03821
    Location:28 → 261
    Mtp; Golgi 4-transmembrane spanning transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    30732469..30757774 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542098.3 → XP_011540400.1  lysosomal-associated transmembrane protein 5 isoform X1

    Conserved Domains (1) summary
    cl04276
    Location:30 → 204
    Mtp; Golgi 4-transmembrane spanning transporter

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    30584986..30610292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338660.1 → XP_054194635.1  lysosomal-associated transmembrane protein 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13571.1 GenPept UniProtKB/Swiss-Prot:Q13571

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
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