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4930451I11Rik RIKEN cDNA 4930451I11 gene [ Mus musculus (house mouse) ]

Gene ID: 78118, updated on 2-Nov-2024

Summary

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Official Symbol
4930451I11Rikprovided by MGI
Official Full Name
RIKEN cDNA 4930451I11 geneprovided by MGI
Primary source
MGI:MGI:1925368
See related
Ensembl:ENSMUSG00000045989 AllianceGenome:MGI:1925368
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fimp
Summary
Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in extracellular region and plasma membrane. Orthologous to human C16orf92 (chromosome 16 open reading frame 92). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 30.6) See more
Orthologs
human all
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Genomic context

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See 4930451I11Rik in Genome Data Viewer
Location:
7 F3; 7 69.25 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126429640..126430712, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126830468..126831540, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10476 Neighboring gene predicted gene, 57854 Neighboring gene aldolase A, fructose-bisphosphate Neighboring gene TLC domain containing 3B Neighboring gene double C2, alpha Neighboring gene INO80 complex subunit E Neighboring gene STARR-positive B cell enhancer ABC_E8843 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134005673-134005856 Neighboring gene HIRA interacting protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of the initial methionine codon of the Tmem95 gene causes subfertility, but not complete infertility, in male mice. Inoue N, et al. Biol Reprod, 2022 Mar 19. PMID 34982145
  2. Spermatozoa lacking Fertilization Influencing Membrane Protein (FIMP) fail to fuse with oocytes in mice. Fujihara Y, et al. Proc Natl Acad Sci U S A, 2020 Apr 28. PMID 32295885, Free PMC Article
  3. Sperm IZUMO1 Is Required for Binding Preceding Fusion With Oolemma in Mice and Rats. Matsumura T, et al. Front Cell Dev Biol, 2021. PMID 35096839, Free PMC Article
  4. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fertilization-influencing membrane protein
Names
uncharacterized protein C16orf92 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183131.3 → NP_898954.2  fertilization-influencing membrane protein precursor

    Status: PROVISIONAL

    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS52402.1
    UniProtKB/Swiss-Prot
    E9Q9R3, Q8CEL4
    Related
    ENSMUSP00000049614.4, ENSMUST00000061695.5
    Conserved Domains (1) summary
    pfam17672
    Location:24 → 111
    DUF5589; Family of unknown function (DUF5589)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126429640..126430712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508347.3 → XP_006508410.1  fertilization-influencing membrane protein isoform X1

    Conserved Domains (1) summary
    pfam17672
    Location:24 → 105
    DUF5589; Family of unknown function (DUF5589)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q9R3.1 GenPept UniProtKB/Swiss-Prot:E9Q9R3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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