U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lpar4 lysophosphatidic acid receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 78134, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Lpar4provided by MGI
Official Full Name
lysophosphatidic acid receptor 4provided by MGI
Primary source
MGI:MGI:1925384
See related
Ensembl:ENSMUSG00000049929 AllianceGenome:MGI:1925384
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LPA4; p2y9; Gpr23; 5730485F04Rik
Summary
Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including branchial arch; cardiovascular system; future brain; limb; and sensory organ. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in limb E14.5 (RPKM 7.9), CNS E11.5 (RPKM 2.4) and 10 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Lpar4 in Genome Data Viewer
Location:
X D; X 47.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (105964231..105977505)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (106920625..106933899)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene retrotransposon Gag like 3 Neighboring gene STARR-seq mESC enhancer starr_47740 Neighboring gene purinergic receptor P2Y, G-protein coupled 10 Neighboring gene STARR-positive B cell enhancer ABC_E11054 Neighboring gene STARR-positive B cell enhancer ABC_E11686 Neighboring gene purinergic receptor P2Y, G-protein coupled 10B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Lee Z, et al. Mol Biol Cell, 2008 Dec. PMID 18843048, Free PMC Article
  2. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells. Igarashi H, et al. Sci Rep, 2015 Jun 19. PMID 26090649, Free PMC Article
  3. LPA receptor 4 deficiency attenuates experimental atherosclerosis. Yang L, et al. J Lipid Res, 2019 May. PMID 30796085, Free PMC Article
  4. LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors. Eino D, et al. Cancer Res, 2018 Dec 1. PMID 30301839
  5. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. Lee CW, et al. J Biol Chem, 2007 Feb 16. PMID 17166850

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The LPAR4 may regulate the recruitment of specific sets of macrophages or their phenotypic switching in a manner that could influence the development of atherosclerosis.
    Title: LPA receptor 4 deficiency attenuates experimental atherosclerosis.
  2. the Galpha12/Galpha13-coupled receptors LPA4 and LPA6 synergistically regulate endothelial Dll4 expression through YAP/TAZ activation
    Title: Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
  3. activation of LPA4 is a promising approach for vascular regulation.
    Title: Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.
  4. LPA4 plays a major role in the lymphocyte transmigration across high endothelial venules
    Title: Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
  5. The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
    Title: The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
  6. These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
    Title: LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
  7. These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
    Title: Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.
  8. a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc
    Title: In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
  9. Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
    Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lysophosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophosphatidic acid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
lysophosphatidic acid receptor 4
Names
G protein-coupled receptor 23
LPA receptor 4
LPA-4
P2Y purinoceptor 9
purinergic receptor 9

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175271.4 → NP_780480.2  lysophosphatidic acid receptor 4

    See identical proteins and their annotated locations for NP_780480.2

    Status: VALIDATED

    Source sequence(s)
    AL670943, BB619126, BC138893
    Consensus CDS
    CCDS30345.1
    UniProtKB/Swiss-Prot
    A2ADM5, Q8BKK1, Q8BLG2, Q8VE54
    Related
    ENSMUSP00000053986.8, ENSMUST00000060576.8
    Conserved Domains (1) summary
    cd15155
    Location:40 → 322
    7tmA_LPAR4; lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    105964231..105977505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLG2.2 GenPept UniProtKB/Swiss-Prot:Q8BLG2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous