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Adgrf4 adhesion G protein-coupled receptor F4 [ Mus musculus (house mouse) ]

Gene ID: 78249, updated on 2-Nov-2024

Summary

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Official Symbol
Adgrf4provided by MGI
Official Full Name
adhesion G protein-coupled receptor F4provided by MGI
Primary source
MGI:MGI:1925499
See related
Ensembl:ENSMUSG00000023918 AllianceGenome:MGI:1925499
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr115; 4632435A09Rik
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within erythrocyte development; glomerular filtration; and pharyngeal arch artery morphogenesis. Predicted to be located in membrane. Is expressed in several structures, including genitourinary system; heart; lung; skin; and thymus. Orthologous to human ADGRF4 (adhesion G protein-coupled receptor F4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 1.5), stomach adult (RPKM 1.3) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrf4 in Genome Data Viewer
Location:
17 B3; 17 19.65 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42967099..43008460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42656208..42697569, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene STARR-seq mESC enhancer starr_42562 Neighboring gene STARR-seq mESC enhancer starr_42563 Neighboring gene STARR-seq mESC enhancer starr_42564 Neighboring gene STARR-seq mESC enhancer starr_42565 Neighboring gene STARR-seq mESC enhancer starr_42566 Neighboring gene patched domain containing 4 Neighboring gene STARR-seq mESC enhancer starr_42567 Neighboring gene STARR-seq mESC enhancer starr_42568 Neighboring gene STARR-seq mESC enhancer starr_42569 Neighboring gene opsin 5 Neighboring gene STARR-seq mESC enhancer starr_42570 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene STARR-positive B cell enhancer mm9_chr17:42919148-42919448 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene CD2-associated protein Neighboring gene STARR-seq mESC enhancer starr_42571 Neighboring gene STARR-positive B cell enhancer ABC_E9167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. Chiba Y, et al. J Biol Chem, 2020 Nov 6. PMID 32868297, Free PMC Article
  2. Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Prömel S, et al. Dev Dyn, 2012 Oct. PMID 22837050
  3. Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4). Lu S, et al. PLoS One, 2017. PMID 28806758, Free PMC Article
  4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts.
    Title: G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC107333, MGC175941

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within erythrocyte development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within glomerular filtration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within pharyngeal arch artery morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor F4
Names
G protein coupled receptor Gpr115
G protein-coupled receptor 115
probable G-protein coupled receptor 115

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289499.1 → NP_001276428.1  adhesion G protein-coupled receptor F4 precursor

    See identical proteins and their annotated locations for NP_001276428.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK019508, BY714064, D18369
    Consensus CDS
    CCDS50113.1
    UniProtKB/Swiss-Prot
    Q5FW81, Q9D2L6
    UniProtKB/TrEMBL
    A0A0D9SEG9
    Related
    ENSMUSP00000132890.2, ENSMUST00000167993.8
    Conserved Domains (3) summary
    cd14964
    Location:405 → 429
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:351 → 394
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:402 → 669
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001289500.1 → NP_001276429.1  adhesion G protein-coupled receptor F4 precursor

    See identical proteins and their annotated locations for NP_001276429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK019508, BY714064, D18369
    Consensus CDS
    CCDS50113.1
    UniProtKB/Swiss-Prot
    Q5FW81, Q9D2L6
    UniProtKB/TrEMBL
    A0A0D9SEG9
    Related
    ENSMUSP00000133261.2, ENSMUST00000170723.8
    Conserved Domains (3) summary
    cd14964
    Location:405 → 429
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:351 → 394
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:402 → 669
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. NM_001289501.1 → NP_001276430.1  adhesion G protein-coupled receptor F4 precursor

    See identical proteins and their annotated locations for NP_001276430.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK019508, BY142177, BY714064, D18369
    Consensus CDS
    CCDS50113.1
    UniProtKB/Swiss-Prot
    Q5FW81, Q9D2L6
    UniProtKB/TrEMBL
    A0A0D9SEG9
    Conserved Domains (3) summary
    cd14964
    Location:405 → 429
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:351 → 394
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:402 → 669
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. NM_030067.2 → NP_084343.1  adhesion G protein-coupled receptor F4 precursor

    See identical proteins and their annotated locations for NP_084343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK019508, D18369
    Consensus CDS
    CCDS50113.1
    UniProtKB/Swiss-Prot
    Q5FW81, Q9D2L6
    UniProtKB/TrEMBL
    A0A0D9SEG9
    Related
    ENSMUSP00000024711.5, ENSMUST00000024711.11
    Conserved Domains (3) summary
    cd14964
    Location:405 → 429
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:351 → 394
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:402 → 669
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    42967099..43008460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317725.2 → XP_017173214.1  adhesion G protein-coupled receptor F4 isoform X1

    UniProtKB/Swiss-Prot
    Q5FW81, Q9D2L6
    UniProtKB/TrEMBL
    A0A0D9SEG9
    Conserved Domains (3) summary
    cd14964
    Location:405 → 429
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam01825
    Location:351 → 394
    GPS; GPCR proteolysis site, GPS, motif
    cl28897
    Location:402 → 669
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2L6.2 GenPept UniProtKB/Swiss-Prot:Q9D2L6

Gene LinkOut

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