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Rps27a ribosomal protein S27A [ Mus musculus (house mouse) ]

Gene ID: 78294, updated on 2-Nov-2024

Summary

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Official Symbol
Rps27aprovided by MGI
Official Full Name
ribosomal protein S27Aprovided by MGI
Primary source
MGI:MGI:1925544
See related
Ensembl:ENSMUSG00000020460 AllianceGenome:MGI:1925544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ubb; Ubc; Uba52; 0610006J14Rik
Summary
Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in modification-dependent protein catabolic process; protein ubiquitination; and ribosomal small subunit biogenesis. Located in myelin sheath. Is active in synapse. Orthologous to several human genes including RPS27A (ribosomal protein S27a). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 445.0), CNS E11.5 (RPKM 386.0) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Rps27a in Genome Data Viewer
Location:
11 A3.3; 11 16.79 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (29495842..29498040, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (29545842..29548040, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3936 Neighboring gene prolyl-tRNA synthetase domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:29426294-29426403 Neighboring gene mitochondrial translational initiation factor 2 Neighboring gene STARR-seq mESC enhancer starr_29024 Neighboring gene clathrin heavy chain linker domain containing 1 Neighboring gene 60S ribosomal protein L7-like Neighboring gene STARR-seq mESC enhancer starr_29025 Neighboring gene ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine polyubiquitin mRNA sequence. Finch JS, et al. Nucleic Acids Res, 1990 Apr 11. PMID 2159627, Free PMC Article
  2. The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a. Fatima G, et al. J Gen Virol, 2012 Apr. PMID 22158882
  3. Molecular identification of a murine ubiquitin/60S ribosomal fusion protein and expression study in mouse kidney. Sun L, et al. Biochem Genet, 1999 Apr. PMID 10495888
  4. Evolution of the mouse polyubiquitin-C gene. Perelygin AA, et al. J Mol Evol, 2002 Aug. PMID 12107596
  5. Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials. Ishiguro T, et al. Cancer Res, 1996 Feb 15. PMID 8631027

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. effector of HBx protein-mediated hepatocarcinogenesis
    Title: The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in myelin sheath HDA PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of small-subunit processome ISO
Inferred from Sequence Orthology
more info
  
part_of small-subunit processome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-ribosomal protein eS31 fusion protein
Names
ubiquitin carboxyl extension protein 80
ubiquitin-40S ribosomal protein S27a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033865.1 → NP_001029037.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

    See identical proteins and their annotated locations for NP_001029037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX284634
    Consensus CDS
    CCDS24497.1
    UniProtKB/Swiss-Prot
    P49664, P62983, Q9D2W3
    UniProtKB/TrEMBL
    Q642L7
    Related
    ENSMUSP00000099908.4, ENSMUST00000102844.4
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 147
    Ribosomal_S27; Ribosomal protein S27a

  2. NM_024277.2 → NP_077239.1  ubiquitin-ribosomal protein eS31 fusion protein precursor

    See identical proteins and their annotated locations for NP_077239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX284634
    Consensus CDS
    CCDS24497.1
    UniProtKB/Swiss-Prot
    P49664, P62983, Q9D2W3
    UniProtKB/TrEMBL
    Q642L7
    Related
    ENSMUSP00000099909.5, ENSMUST00000102845.11
    Conserved Domains (2) summary
    cd01803
    Location:1 → 76
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01599
    Location:103 → 147
    Ribosomal_S27; Ribosomal protein S27a

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    29495842..29498040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62983.2 GenPept UniProtKB/Swiss-Prot:P62983

Gene LinkOut

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