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Ddx52 DExD box helicase 52 [ Mus musculus (house mouse) ]

Gene ID: 78394, updated on 28-Oct-2024

Summary

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Official Symbol
Ddx52provided by MGI
Official Full Name
DExD box helicase 52provided by MGI
Primary source
MGI:MGI:1925644
See related
Ensembl:ENSMUSG00000020677 AllianceGenome:MGI:1925644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ROK1; 2700029C06Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleolus. Is expressed in heart and limb. Orthologous to human DDX52 (DExD-box helicase 52). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.1), placenta adult (RPKM 9.6) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx52 in Genome Data Viewer
Location:
11 C; 11 51.24 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (83831659..83853914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (83942090..83963088)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8436 Neighboring gene predicted gene 12576 Neighboring gene STARR-positive B cell enhancer ABC_E3983 Neighboring gene STARR-positive B cell enhancer ABC_E7031 Neighboring gene HNF1 homeobox B Neighboring gene STARR-seq mESC enhancer starr_30206 Neighboring gene STARR-seq mESC enhancer starr_30207 Neighboring gene predicted gene, 51869 Neighboring gene STARR-positive B cell enhancer ABC_E5256 Neighboring gene STARR-positive B cell enhancer ABC_E11769 Neighboring gene synergin, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr11:83845520-83845821 Neighboring gene dual specificity phosphatase 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis. Mori AD, et al. Dev Biol, 2006 Sep 15. PMID 16870172
  2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX52
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DEAD box protein 52
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 52
NP_084372.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030096.2 → NP_084372.2  probable ATP-dependent RNA helicase DDX52

    See identical proteins and their annotated locations for NP_084372.2

    Status: VALIDATED

    Source sequence(s)
    AK141200, AK166789, AL645615, CJ142321, CN539261
    Consensus CDS
    CCDS25180.1
    UniProtKB/Swiss-Prot
    Q3UZY9, Q8BV29, Q8K301
    UniProtKB/TrEMBL
    Q3TKX4
    Related
    ENSMUSP00000048802.8, ENSMUST00000049257.8
    Conserved Domains (3) summary
    PRK11192
    Location:163 → 597
    PRK11192; ATP-dependent RNA helicase SrmB; Provisional
    pfam00271
    Location:399 → 508
    Helicase_C; Helicase conserved C-terminal domain
    cl21455
    Location:170 → 376
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    83831659..83853914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004937057.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K301.2 GenPept UniProtKB/Swiss-Prot:Q8K301

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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