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Arhgap10 Rho GTPase activating protein 10 [ Mus musculus (house mouse) ]

Gene ID: 78514, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap10provided by MGI
Official Full Name
Rho GTPase activating protein 10provided by MGI
Primary source
MGI:MGI:1925764
See related
Ensembl:ENSMUSG00000037148 AllianceGenome:MGI:1925764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSGAP; PS-GAP; PSGAP-m; PSGAP-s; A930033B01Rik
Summary
Enables GTPase activator activity. Involved in negative regulation of apoptotic process. Acts upstream of or within cytoskeleton organization. Located in cytosol. Is expressed in brain. Orthologous to human ARHGAP10 (Rho GTPase activating protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 13.3), bladder adult (RPKM 9.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap10 in Genome Data Viewer
Location:
8 C1; 8 36.6 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (77976995..78244628, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77250366..77517999, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear receptor subfamily 3, group C, member 2 Neighboring gene predicted gene, 24838 Neighboring gene predicted gene, 23260 Neighboring gene STARR-seq mESC enhancer starr_21951 Neighboring gene STARR-seq mESC enhancer starr_21952 Neighboring gene STARR-seq mESC enhancer starr_21953 Neighboring gene predicted gene 45407 Neighboring gene STARR-seq mESC enhancer starr_21954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:79946917-79947070 Neighboring gene RIKEN cDNA 0610038B21 gene Neighboring gene STARR-seq mESC enhancer starr_21957 Neighboring gene STARR-positive B cell enhancer ABC_E9317 Neighboring gene STARR-positive B cell enhancer ABC_E8249 Neighboring gene STARR-seq mESC enhancer starr_21958 Neighboring gene STARR-positive B cell enhancer ABC_E1761 Neighboring gene protein arginine methyltransferase 9 Neighboring gene transmembrane protein 184C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk. Sekiguchi M, et al. Transl Psychiatry, 2020 Jul 22. PMID 32699248, Free PMC Article
  2. ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells. Luo N, et al. Cell Death Dis, 2016 Mar 24. PMID 27010858, Free PMC Article
  3. Identification and characterization of PS-GAP as a novel regulator of caspase-activated PAK-2. Koeppel MA, et al. J Biol Chem, 2004 Dec 17. PMID 15471851
  4. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons. Hada K, et al. Mol Brain, 2021 Jan 22. PMID 33482876, Free PMC Article
  5. Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. Ren XR, et al. J Cell Biol, 2001 Mar 5. PMID 11238453, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
    Title: Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.
  2. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways.
    Title: ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (6)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 10
Names
PH and SH3 domain-containing rhoGAP protein
rho-type GTPase-activating protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363417.1 → NP_001350346.1  rho GTPase-activating protein 10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248
    Consensus CDS
    CCDS90420.1
    Related
    ENSMUSP00000147493.2, ENSMUST00000210519.2
    Conserved Domains (5) summary
    cd12065
    Location:710 → 763
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:367 → 547
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl25496
    Location:553 → 699
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  2. NM_001363418.1 → NP_001350347.1  rho GTPase-activating protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248
    Consensus CDS
    CCDS90421.1
    Related
    ENSMUSP00000147485.2, ENSMUST00000210922.2
    Conserved Domains (4) summary
    cd12065
    Location:681 → 734
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:367 → 569
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. NM_001363419.1 → NP_001350348.1  rho GTPase-activating protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248
    Conserved Domains (5) summary
    cd12065
    Location:629 → 682
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    NF033913
    Location:518 → 616
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. NM_001363420.1 → NP_001350349.1  rho GTPase-activating protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248
    Conserved Domains (5) summary
    cd12065
    Location:607 → 660
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:264 → 444
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl25496
    Location:450 → 596
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  5. NM_001363421.1 → NP_001350350.1  rho GTPase-activating protein 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248
    Conserved Domains (4) summary
    cd12065
    Location:578 → 631
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:264 → 466
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. NM_030113.2 → NP_084389.2  rho GTPase-activating protein 10 isoform 1

    See identical proteins and their annotated locations for NP_084389.2

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248, AK041867, BI736055, BU151977, CF106470, CN703944, CV783737
    Consensus CDS
    CCDS22425.1
    UniProtKB/Swiss-Prot
    Q6Y5D6, Q6Y5D7, Q6Y5D8, Q99MT3, Q99MT4
    Related
    ENSMUSP00000075658.5, ENSMUST00000076316.6
    Conserved Domains (5) summary
    cd12065
    Location:732 → 785
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:367 → 569
    RhoGAP_Graf; RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences ...
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam00169
    Location:269 → 367
    PH; PH domain
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. NR_156496.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109139, AC119248

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    77976995..78244628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154381.1 → XP_036010274.1  rho GTPase-activating protein 10 isoform X4

    Conserved Domains (5) summary
    cd12065
    Location:660 → 713
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:295 → 497
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:195 → 300
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    NF033913
    Location:549 → 647
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl12013
    Location:19 → 177
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_017313016.2 → XP_017168505.1  rho GTPase-activating protein 10 isoform X2

    Conserved Domains (5) summary
    cd12065
    Location:707 → 760
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam17061
    Location:550 → 696
    PARM
    cl02570
    Location:367 → 544
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_017313015.3 → XP_017168504.1  rho GTPase-activating protein 10 isoform X1

    Conserved Domains (5) summary
    cd12065
    Location:708 → 761
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:343 → 545
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:243 → 348
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam17061
    Location:551 → 697
    PARM
    cl12013
    Location:19 → 201
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_011248553.4 → XP_011246855.1  rho GTPase-activating protein 10 isoform X3

    Conserved Domains (5) summary
    cd12065
    Location:688 → 741
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:323 → 525
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:223 → 328
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam17061
    Location:531 → 677
    PARM
    cl12013
    Location:9 → 181
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  5. XM_036154382.1 → XP_036010275.1  rho GTPase-activating protein 10 isoform X5

    Conserved Domains (5) summary
    cd12065
    Location:629 → 682
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:264 → 466
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    NF033913
    Location:518 → 616
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_017313020.3 → XP_017168509.1  rho GTPase-activating protein 10 isoform X7

    Conserved Domains (5) summary
    cd12065
    Location:604 → 657
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd01249
    Location:164 → 269
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam17061
    Location:447 → 593
    PARM
    cl02570
    Location:264 → 441
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:1 → 122
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  7. XM_017313019.2 → XP_017168508.1  rho GTPase-activating protein 10 isoform X6

    Conserved Domains (5) summary
    cd12065
    Location:605 → 658
    SH3_GRAF2; Src Homology 3 domain of GTPase Regulator Associated with Focal adhesion kinase 2
    cd04374
    Location:240 → 442
    RhoGAP_Graf; GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal ...
    cd01249
    Location:140 → 245
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    pfam17061
    Location:448 → 594
    PARM
    cl12013
    Location:2 → 98
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  8. XM_017313022.2 → XP_017168511.1  rho GTPase-activating protein 10 isoform X8

    Conserved Domains (3) summary
    cd01249
    Location:267 → 372
    BAR-PH_GRAF_family; GTPase Regulator Associated with Focal adhesion and related proteins Pleckstrin homology (PH) domain
    cl02570
    Location:367 → 399
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    cl12013
    Location:19 → 225
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001778487.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6Y5D8.2 GenPept UniProtKB/Swiss-Prot:Q6Y5D8

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