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Asb8 ankyrin repeat and SOCS box-containing 8 [ Mus musculus (house mouse) ]

Gene ID: 78541, updated on 2-Nov-2024

Summary

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Official Symbol
Asb8provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 8provided by MGI
Primary source
MGI:MGI:1925791
See related
Ensembl:ENSMUSG00000048175 AllianceGenome:MGI:1925791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930539L19Rik; C430011H06Rik
Summary
Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Orthologous to human ASB8 (ankyrin repeat and SOCS box containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 37.0), heart adult (RPKM 27.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Asb8 in Genome Data Viewer
Location:
15 F1; 15 54.13 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98032518..98063476, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98134637..98165596, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene SUMO1/sentrin specific peptidase 1 Neighboring gene predicted gene, 25668 Neighboring gene STARR-seq mESC enhancer starr_39649 Neighboring gene STARR-positive B cell enhancer ABC_E10879 Neighboring gene STARR-positive B cell enhancer ABC_E5514 Neighboring gene STARR-seq mESC enhancer starr_39650 Neighboring gene phosphofructokinase, muscle Neighboring gene STARR-seq mESC enhancer starr_39651 Neighboring gene STARR-seq mESC enhancer starr_39652 Neighboring gene STARR-seq mESC enhancer starr_39654 Neighboring gene STARR-positive B cell enhancer ABC_E5515 Neighboring gene coiled-coil domain containing 184 Neighboring gene predicted gene, 33909 Neighboring gene olfactory receptor family 10 subfamily AD member 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of the human ASB-8 gene encoding a novel member of ankyrin repeat and SOCS box containing protein family. Liu Y, et al. Biochem Biophys Res Commun, 2003 Jan 24. PMID 12559969
  2. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 8
Names
ASB-8
ankyrin repeat and SOCS box-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170710.1 → NP_001164181.1  ankyrin repeat and SOCS box protein 8

    See identical proteins and their annotated locations for NP_001164181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK016001, AK030168, AK087299, BY240190
    Consensus CDS
    CCDS27787.1
    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Related
    ENSMUSP00000121383.2, ENSMUST00000123626.8
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  2. NM_001170711.1 → NP_001164182.1  ankyrin repeat and SOCS box protein 8

    See identical proteins and their annotated locations for NP_001164182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK016001, AK030168
    Consensus CDS
    CCDS27787.1
    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Related
    ENSMUSP00000115813.2, ENSMUST00000143400.8
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  3. NM_030121.4 → NP_084397.3  ankyrin repeat and SOCS box protein 8

    See identical proteins and their annotated locations for NP_084397.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK016001, AK030168, BY240190
    Consensus CDS
    CCDS27787.1
    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Related
    ENSMUSP00000057864.6, ENSMUST00000059112.12
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98032518..98063476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521542.5 → XP_006521605.1  ankyrin repeat and SOCS box protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006521605.1

    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  2. XM_030248819.2 → XP_030104679.1  ankyrin repeat and SOCS box protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  3. XM_011245775.4 → XP_011244077.1  ankyrin repeat and SOCS box protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011244077.1

    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Related
    ENSMUSP00000119481.2, ENSMUST00000123922.2
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]

  4. XM_030248820.2 → XP_030104680.1  ankyrin repeat and SOCS box protein 8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R178, Q91ZT9
    UniProtKB/TrEMBL
    A0A0R4J1W1, Q8CDF0, Q9D4Y2
    Conserved Domains (3) summary
    PHA02876
    Location:26 → 215
    PHA02876; ankyrin repeat protein; Provisional
    cd03727
    Location:245 → 287
    SOCS_ASB8; SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The ...
    sd00045
    Location:56 → 83
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZT9.1 GenPept UniProtKB/Swiss-Prot:Q91ZT9

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