U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pabir2 PABIR family member 2 [ Mus musculus (house mouse) ]

Gene ID: 78755, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Pabir2provided by MGI
Official Full Name
PABIR family member 2provided by MGI
Primary source
MGI:MGI:1926005
See related
Ensembl:ENSMUSG00000036022 AllianceGenome:MGI:1926005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam122b; SPACIA2; 4632404H22Rik
Summary
Predicted to enable protein serine/threonine phosphatase inhibitor activity. Is expressed in several structures, including central nervous system; hindlimb digit mesenchyme; sensory organ; skeleton; and trachea. Orthologous to human PABIR2 (PABIR family member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 12.7), limb E14.5 (RPKM 5.4) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Pabir2 in Genome Data Viewer
Location:
X A5; X 29.43 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52332292..52358728, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53243415..53269850, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized LOC119919412 Neighboring gene STARR-seq mESC enhancer starr_47192 Neighboring gene Mir503, Mir351, and Mir322 host gene Neighboring gene microRNA 322 Neighboring gene predicted gene, 35988 Neighboring gene placental specific protein 1 Neighboring gene PABIR family member 3 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene motile sperm domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans. Sato T, et al. Arthritis Rheum, 2011 Dec. PMID 22127701
  2. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein serine/threonine phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PABIR family member 2
Names
family with sequence similarity 122, member B
protein FAM122B
synoviocyte proliferation associated in collagen-induced arthritis 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166365.2 → NP_001159837.2  PABIR family member 2 isoform 1

    See identical proteins and their annotated locations for NP_001159837.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
    Source sequence(s)
    AK019480, AK044896, BB068834
    Consensus CDS
    CCDS53070.1
    UniProtKB/Swiss-Prot
    B1B0Y4, B1B0Y5, Q6NZE7, Q8BRG5, Q8CBB0, Q9D2N2
    UniProtKB/TrEMBL
    G1UD78
    Related
    ENSMUSP00000110487.2, ENSMUST00000114838.8

  2. NM_001166583.1 → NP_001160055.1  PABIR family member 2 isoform 3

    See identical proteins and their annotated locations for NP_001160055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses a different splice site in the 3' coding region which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK036417, AK044896, BB068834, BX519788
    Consensus CDS
    CCDS53069.1
    UniProtKB/Swiss-Prot
    Q6NZE7
    Related
    ENSMUSP00000110490.2, ENSMUST00000114841.2

  3. NM_030167.4 → NP_084443.1  PABIR family member 2 isoform 2

    See identical proteins and their annotated locations for NP_084443.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that adds one codon to the internal coding region, compared to variant 1. This variant encodes isoform 2.
    Source sequence(s)
    AK019480, AK044896, BB068834
    Consensus CDS
    CCDS30129.1
    UniProtKB/Swiss-Prot
    Q6NZE7
    Related
    ENSMUSP00000069112.6, ENSMUST00000071023.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    52332292..52358728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541556.5 → XP_006541619.1  PABIR family member 2 isoform X1

  2. XM_036162120.1 → XP_036018013.1  PABIR family member 2 isoform X2

  3. XM_030251521.2 → XP_030107381.1  PABIR family member 2 isoform X6

  4. XM_011251023.4 → XP_011249325.1  PABIR family member 2 isoform X4

  5. XM_036162122.1 → XP_036018015.1  PABIR family member 2 isoform X5

  6. XM_036162121.1 → XP_036018014.1  PABIR family member 2 isoform X3

  7. XM_006541557.5 → XP_006541620.1  PABIR family member 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZE7.2 GenPept UniProtKB/Swiss-Prot:Q6NZE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools