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Brpf1 bromodomain and PHD finger containing, 1 [ Mus musculus (house mouse) ]

Gene ID: 78783, updated on 2-Nov-2024

Summary

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Official Symbol
Brpf1provided by MGI
Official Full Name
bromodomain and PHD finger containing, 1provided by MGI
Primary source
MGI:MGI:1926033
See related
Ensembl:ENSMUSG00000001632 AllianceGenome:MGI:1926033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brpf2; 4833438B11Rik; 4930540D11Rik
Summary
Predicted to enable acetyltransferase activator activity. Predicted to contribute to histone H4K12 acetyltransferase activity; histone H4K5 acetyltransferase activity; and histone H4K8 acetyltransferase activity. Involved in chromatin remodeling. Acts upstream of or within common myeloid progenitor cell proliferation; regulation of fibroblast proliferation; and tube morphogenesis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study syndromic intellectual disability. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 16.2), CNS E11.5 (RPKM 12.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Brpf1 in Genome Data Viewer
Location:
6 E3; 6 52.75 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (113283824..113301823)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (113306863..113324862)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E683 Neighboring gene myotubularin related protein 14 Neighboring gene copine family member IX Neighboring gene STARR-seq mESC enhancer starr_17036 Neighboring gene STARR-positive B cell enhancer ABC_E237 Neighboring gene STARR-positive B cell enhancer ABC_E1326 Neighboring gene 8-oxoguanine DNA-glycosylase 1 Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing Tcp1, subunit 3 (gamma) pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory. Zhao B, et al. Neural Regen Res, 2024 May. PMID 37862219, Free PMC Article
  2. Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells. He Q, et al. J Mol Cell Biol, 2020 Jun 11. PMID 31565729, Free PMC Article
  3. [BRPF2, a novel transcript of BRPF1 and their expression in mice tissues]. Guo F, et al. Yi Chuan, 2013 Jan. PMID 23357268
  4. Brpf1 Haploinsufficiency Impairs Dendritic Arborization and Spine Formation, Leading to Cognitive Deficits. Su Y, et al. Front Cell Neurosci, 2019. PMID 31213987, Free PMC Article
  5. BRPF1 is essential for development of fetal hematopoietic stem cells. You L, et al. J Clin Invest, 2016 Sep 1. PMID 27500495, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells.
    Title: Isoform-specific involvement of Brpf1 in expansion of adult hematopoietic stem and progenitor cells.
  2. BRPF1 has a role in development of fetal hematopoietic stem cells
    Title: BRPF1 is essential for development of fetal hematopoietic stem cells.
  3. We further demonstrate that Brpf1 loss deregulates neuronal migration, cell cycle progression and transcriptional control, thereby causing abnormal morphogenesis of the hippocampus
    Title: The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors.
  4. a crucial role of Brpf1 in controlling mouse embryo development and regulating cellular and gene expression programs
    Title: The chromatin regulator Brpf1 regulates embryo development and cell proliferation.
  5. The 4-dimensional expression atlas of mouse Brpf1 serves as a valuable guide for analyzing its interaction with Moz, Morf, and Hbo1 in vivo, and for investigating whether Brpf1 functions independently of these three enzymatic epigenetic regulators.
    Title: Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.
  6. Forebrain-specific inactivation of the Brpf1 gene causes neocortical abnormalities and partial agenesis of the corpus callosum.
    Title: Deficiency of the chromatin regulator BRPF1 causes abnormal brain development.
  7. BRPF2 was a novel transcript of BRPF1.
    Title: [BRPF2, a novel transcript of BRPF1 and their expression in mice tissues].
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • 4833438B11Rik, 4930540D11Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acetyltransferase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables acetyltransferase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MOZ/MORF histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of MOZ/MORF histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peregrin
Names
bromodomain and PHD finger-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282126.1 → NP_001269055.1  peregrin isoform 1

    See identical proteins and their annotated locations for NP_001269055.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC155287, AK019522, AK043372, BC046521, BY469507
    Consensus CDS
    CCDS71809.1
    UniProtKB/TrEMBL
    B7ZNI3, Q3U109
    Related
    ENSMUSP00000108744.2, ENSMUST00000113119.8
    Conserved Domains (5) summary
    cd05839
    Location:1116 → 1231
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  2. NM_001282127.1 → NP_001269056.1  peregrin isoform 3

    See identical proteins and their annotated locations for NP_001269056.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple differences in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK019522, AK043372, BC046521, BY469507
    Consensus CDS
    CCDS71810.1
    UniProtKB/Swiss-Prot
    B2RRD7
    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1081 → 1196
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  3. NM_001282128.1 → NP_001269057.1  peregrin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site, and lacks an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
    Source sequence(s)
    AC155287, AK019522, AK043372, BC046521, BY469507
    Consensus CDS
    CCDS85115.1
    UniProtKB/TrEMBL
    A0A0N4SVG7, B7ZNI3
    Related
    ENSMUSP00000145093.2, ENSMUST00000204626.3
    Conserved Domains (5) summary
    cd05839
    Location:1087 → 1202
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  4. NM_030178.2 → NP_084454.1  peregrin isoform 2

    See identical proteins and their annotated locations for NP_084454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK019522, AK043372, BC046521, BY469507
    Consensus CDS
    CCDS39592.1
    UniProtKB/TrEMBL
    B7ZNI3, Q80XK2
    Related
    ENSMUSP00000108742.2, ENSMUST00000113117.4
    Conserved Domains (5) summary
    cd05839
    Location:1115 → 1230
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    113283824..113301823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506782.5 → XP_006506845.1  peregrin isoform X1

    See identical proteins and their annotated locations for XP_006506845.1

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1122 → 1237
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  2. XM_006506786.5 → XP_006506849.1  peregrin isoform X5

    UniProtKB/TrEMBL
    B7ZNI3, E9PXP1
    Related
    ENSMUSP00000108746.3, ENSMUST00000113121.8
    Conserved Domains (5) summary
    cd05839
    Location:1088 → 1203
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  3. XM_017321837.3 → XP_017177326.1  peregrin isoform X9

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1027 → 1142
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  4. XM_036152405.1 → XP_036008298.1  peregrin isoform X10

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:993 → 1108
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  5. XM_006506784.5 → XP_006506847.1  peregrin isoform X2

    UniProtKB/TrEMBL
    A0A0N4SUT9, B7ZNI3
    Related
    ENSMUSP00000144820.2, ENSMUST00000203577.2
    Conserved Domains (5) summary
    cd05839
    Location:1121 → 1236
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  6. XM_006506783.4 → XP_006506846.1  peregrin isoform X1

    See identical proteins and their annotated locations for XP_006506846.1

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1122 → 1237
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  7. XM_036152403.1 → XP_036008296.1  peregrin isoform X2

    UniProtKB/TrEMBL
    A0A0N4SUT9, B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1121 → 1236
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  8. XM_036152404.1 → XP_036008297.1  peregrin isoform X6

    UniProtKB/TrEMBL
    A0A0N4SVG7, B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1087 → 1202
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 734
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  9. XM_006506785.4 → XP_006506848.1  peregrin isoform X4

    See identical proteins and their annotated locations for XP_006506848.1

    UniProtKB/TrEMBL
    B7ZNI3, Q80XK2
    Conserved Domains (5) summary
    cd05839
    Location:1115 → 1230
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  10. XM_006506788.4 → XP_006506851.1  peregrin isoform X8

    See identical proteins and their annotated locations for XP_006506851.1

    UniProtKB/Swiss-Prot
    B2RRD7
    UniProtKB/TrEMBL
    B7ZNI3
    Related
    ENSMUSP00000108747.2, ENSMUST00000113122.8
    Conserved Domains (5) summary
    cd05839
    Location:1081 → 1196
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  11. XM_006506787.4 → XP_006506850.1  peregrin isoform X7

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1082 → 1197
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  12. XM_017321839.2 → XP_017177328.1  peregrin isoform X11

    UniProtKB/TrEMBL
    A0A0N4SUS4, B7ZNI3
    Related
    ENSMUSP00000144804.2, ENSMUST00000204198.3
    Conserved Domains (5) summary
    cd05839
    Location:987 → 1102
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  13. XM_030255678.2 → XP_030111538.1  peregrin isoform X3

    UniProtKB/TrEMBL
    B7ZNI3, Q3U109
    Conserved Domains (5) summary
    cd05839
    Location:1116 → 1231
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins

  14. XM_030255679.2 → XP_030111539.1  peregrin isoform X7

    UniProtKB/TrEMBL
    B7ZNI3
    Conserved Domains (5) summary
    cd05839
    Location:1082 → 1197
    BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...
    cd05512
    Location:631 → 728
    Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...
    COG5141
    Location:173 → 656
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    COG5189
    Location:20 → 50
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    cd15701
    Location:329 → 449
    ePHD_BRPF1; Extended PHD finger found in bromodomain and PHD finger-containing protein 1 (BRPF1) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RRD7.1 GenPept UniProtKB/Swiss-Prot:B2RRD7

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