U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clip4 CAP-GLY domain containing linker protein family, member 4 [ Mus musculus (house mouse) ]

Gene ID: 78785, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Clip4provided by MGI
Official Full Name
CAP-GLY domain containing linker protein family, member 4provided by MGI
Primary source
MGI:MGI:1919100
See related
Ensembl:ENSMUSG00000024059 AllianceGenome:MGI:1919100
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsnl2; 1700024K14Rik; 1700074B05Rik; 4833417L20Rik; 5830409B12Rik
Summary
Predicted to enable microtubule plus-end binding activity. Predicted to be involved in cytoplasmic microtubule organization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cell cortex; microtubule plus-end; and nucleus. Is expressed in bladder; trunk mesenchyme; and urethra. Orthologous to human CLIP4 (CAP-Gly domain containing linker protein family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 58.9), heart adult (RPKM 24.2) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Clip4 in Genome Data Viewer
Location:
17 E1.3; 17 42.9 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72076674..72171205)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71769674..71864210)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10969 Neighboring gene TOG array regulator of axonemal microtubules 2 Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene STARR-seq mESC enhancer starr_43180 Neighboring gene anaplastic lymphoma kinase Neighboring gene STARR-seq mESC enhancer starr_43182 Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CAP-Gly domain-containing linker protein 4
Names
restin-like protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271483.1 → NP_001258412.1  CAP-Gly domain-containing linker protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001258412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154458, AK019516
    Consensus CDS
    CCDS89147.1
    UniProtKB/TrEMBL
    A0A2R8VJW4
    Related
    ENSMUSP00000154969.2, ENSMUST00000229874.2
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_001271484.1 → NP_001258413.1  CAP-Gly domain-containing linker protein 4 isoform 4

    See identical proteins and their annotated locations for NP_001258413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate 3' exon structure, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK029962, AK161301, AV260889
    Consensus CDS
    CCDS89148.1
    UniProtKB/TrEMBL
    Q3TTL7
    Related
    ENSMUSP00000154878.2, ENSMUST00000230333.2
    Conserved Domains (4) summary
    cd00204
    Location:98 → 252
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam01302
    Location:487 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]

  3. NM_030179.3 → NP_084455.2  CAP-Gly domain-containing linker protein 4 isoform 1

    See identical proteins and their annotated locations for NP_084455.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC154458, AC154569
    Consensus CDS
    CCDS37687.1
    UniProtKB/Swiss-Prot
    Q8BW09, Q8CI96, Q921Q4, Q9D2S6
    Related
    ENSMUSP00000024854.8, ENSMUST00000024854.9
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  4. NM_175378.1 → NP_780587.1  CAP-Gly domain-containing linker protein 4 isoform 2

    See identical proteins and their annotated locations for NP_780587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains multiple differences in the UTRs and coding region, one of which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154458, AC154569
    Consensus CDS
    CCDS89149.1
    UniProtKB/Swiss-Prot
    Q8CI96
    Related
    ENSMUSP00000155140.2, ENSMUST00000229952.2
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439 → 503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. NR_073185.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains multiple differences compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC154458, AK029962
    Related
    ENSMUST00000230747.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    72076674..72171205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250146.2 → XP_030106006.1  CAP-Gly domain-containing linker protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VJW4
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006525144.4 → XP_006525207.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525207.1

    UniProtKB/Swiss-Prot
    Q8BW09, Q8CI96, Q921Q4, Q9D2S6
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006525146.1 → XP_006525209.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525209.1

    UniProtKB/Swiss-Prot
    Q8BW09, Q8CI96, Q921Q4, Q9D2S6
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006525145.5 → XP_006525208.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525208.1

    UniProtKB/Swiss-Prot
    Q8BW09, Q8CI96, Q921Q4, Q9D2S6
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_006525147.5 → XP_006525210.1  CAP-Gly domain-containing linker protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006525210.1

    UniProtKB/TrEMBL
    A0A2R8VJW4
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006525153.4 → XP_006525216.1  CAP-Gly domain-containing linker protein 4 isoform X7

    See identical proteins and their annotated locations for XP_006525216.1

    UniProtKB/TrEMBL
    A0A2R8VHV0
    Related
    ENSMUSP00000155653.2, ENSMUST00000229304.2
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285 → 349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_030250147.2 → XP_030106007.1  CAP-Gly domain-containing linker protein 4 isoform X4

    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439 → 503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_006525143.5 → XP_006525206.1  CAP-Gly domain-containing linker protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006525206.1

    UniProtKB/Swiss-Prot
    Q8BW09, Q8CI96, Q921Q4, Q9D2S6
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_006525150.4 → XP_006525213.1  CAP-Gly domain-containing linker protein 4 isoform X5

    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:486 → 550
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_006525151.4 → XP_006525214.1  CAP-Gly domain-containing linker protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A2R8VHV0
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285 → 349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_036160848.1 → XP_036016741.1  CAP-Gly domain-containing linker protein 4 isoform X7

    UniProtKB/TrEMBL
    A0A2R8VHV0
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:285 → 349
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_006525148.5 → XP_006525211.1  CAP-Gly domain-containing linker protein 4 isoform X3

    See identical proteins and their annotated locations for XP_006525211.1

    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439 → 503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_006525154.4 → XP_006525217.1  CAP-Gly domain-containing linker protein 4 isoform X8

    See identical proteins and their annotated locations for XP_006525217.1

    UniProtKB/Swiss-Prot
    Q8CI96
    Conserved Domains (3) summary
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
    pfam01302
    Location:439 → 503
    CAP_GLY; CAP-Gly domain
    pfam12796
    Location:111 → 217
    Ank_2; Ankyrin repeats (3 copies)

RNA

  1. XR_385397.5 RNA Sequence

  2. XR_003952214.2 RNA Sequence

  3. XR_003952215.2 RNA Sequence

  4. XR_001782131.3 RNA Sequence

  5. XR_004939602.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CI96.1 GenPept UniProtKB/Swiss-Prot:Q8CI96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools