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Stpg1 sperm tail PG rich repeat containing 1 [ Mus musculus (house mouse) ]

Gene ID: 78806, updated on 2-Nov-2024

Summary

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Official Symbol
Stpg1provided by MGI
Official Full Name
sperm tail PG rich repeat containing 1provided by MGI
Primary source
MGI:MGI:1926056
See related
Ensembl:ENSMUSG00000028801 AllianceGenome:MGI:1926056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mapo2; 4930403G18Rik; 4930555I21Rik
Summary
Predicted to be involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. Orthologous to human STPG1 (sperm tail PG-rich repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward testis adult (RPKM 36.0) See more
Orthologs
human all
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Genomic context

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See Stpg1 in Genome Data Viewer
Location:
4 D3; 4 67.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135221971..135265015)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135494670..135537803)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene noncompact myelin associated protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134982608-134982761 Neighboring gene regulator of calcineurin 3 Neighboring gene microRNA 700 Neighboring gene STARR-positive B cell enhancer ABC_E9603 Neighboring gene STARR-positive B cell enhancer ABC_E1286 Neighboring gene NIPA-like domain containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:135050361-135050662 Neighboring gene STARR-seq mESC enhancer starr_11721 Neighboring gene STARR-seq mESC enhancer starr_11724 Neighboring gene grainyhead like transcription factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E6235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:135126769-135126952 Neighboring gene STARR-seq mESC enhancer starr_11727 Neighboring gene predicted gene, 30888 Neighboring gene STARR-seq mESC enhancer starr_11728 Neighboring gene STARR-seq mESC enhancer starr_11730 Neighboring gene RIKEN cDNA 1700029M20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. Fujikane R, et al. PLoS One, 2012. PMID 23028632, Free PMC Article
  2. Post-entrapment genome engineering: first exon size does not affect the expression of fusion transcripts generated by gene entrapment. Osipovich AB, et al. Genome Res, 2005 Mar. PMID 15741512, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MAPO2 gene product might positively contribute to the induction of apoptosis triggered by O-methylguanine
    Title: The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O(6)-methylguanine-induced apoptosis 2
Names
O6-methylguanine-induced apoptosis 2
UPF0490 protein C1orf201 homolog
sperm-tail PG-rich repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419281.1 → NP_001406210.1  O(6)-methylguanine-induced apoptosis 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL670720
    UniProtKB/Swiss-Prot
    Q9D2F5

  2. NM_001419282.1 → NP_001406211.1  O(6)-methylguanine-induced apoptosis 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL670720

  3. NM_001419286.1 → NP_001406215.1  O(6)-methylguanine-induced apoptosis 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL670720

  4. NM_001419287.1 → NP_001406216.1  O(6)-methylguanine-induced apoptosis 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL670720

  5. NM_030189.4 → NP_084465.1  O(6)-methylguanine-induced apoptosis 2 isoform a

    See identical proteins and their annotated locations for NP_084465.1

    Status: VALIDATED

    Source sequence(s)
    AL670720
    Consensus CDS
    CCDS18787.1
    UniProtKB/Swiss-Prot
    Q9D2F5
    UniProtKB/TrEMBL
    A6H5V9
    Related
    ENSMUSP00000067647.3, ENSMUST00000063707.3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135221971..135265015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320458.3 → XP_017175947.1  O(6)-methylguanine-induced apoptosis 2 isoform X5

  2. XM_017320457.3 → XP_017175946.1  O(6)-methylguanine-induced apoptosis 2 isoform X4

    UniProtKB/TrEMBL
    A6H5V9

  3. XM_006539286.5 → XP_006539349.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    See identical proteins and their annotated locations for XP_006539349.1

    UniProtKB/Swiss-Prot
    Q9D2F5
    UniProtKB/TrEMBL
    A6H5V9

  4. XM_006539285.4 → XP_006539348.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    See identical proteins and their annotated locations for XP_006539348.1

    UniProtKB/Swiss-Prot
    Q9D2F5
    UniProtKB/TrEMBL
    A6H5V9

  5. XM_006539287.4 → XP_006539350.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    See identical proteins and their annotated locations for XP_006539350.1

    UniProtKB/Swiss-Prot
    Q9D2F5
    UniProtKB/TrEMBL
    A6H5V9

  6. XM_011250356.3 → XP_011248658.1  O(6)-methylguanine-induced apoptosis 2 isoform X1

    See identical proteins and their annotated locations for XP_011248658.1

    UniProtKB/Swiss-Prot
    Q9D2F5
    UniProtKB/TrEMBL
    A6H5V9

  7. XM_006539288.2 → XP_006539351.1  O(6)-methylguanine-induced apoptosis 2 isoform X2

    UniProtKB/TrEMBL
    A6H5V9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D2F5.1 GenPept UniProtKB/Swiss-Prot:Q9D2F5

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