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Igsf3 immunoglobulin superfamily, member 3 [ Mus musculus (house mouse) ]

Gene ID: 78908, updated on 2-Nov-2024

Summary

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Official Symbol
Igsf3provided by MGI
Official Full Name
immunoglobulin superfamily, member 3provided by MGI
Primary source
MGI:MGI:1926158
See related
Ensembl:ENSMUSG00000042035 AllianceGenome:MGI:1926158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0466; 1700016K10Rik; 2810035F16Rik; 4833439O17Rik
Summary
Predicted to be involved in lacrimal gland development. Predicted to be active in membrane. Is expressed in dorsal root ganglion; lung; and spinal cord. Human ortholog(s) of this gene implicated in lacrimal duct obstruction. Orthologous to human IGSF3 (immunoglobulin superfamily member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 8.2), limb E14.5 (RPKM 8.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Igsf3 in Genome Data Viewer
Location:
3 F2.2; 3 44.3 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101284306..101370375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101376672..101463060)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08527 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_08529 Neighboring gene STARR-seq mESC enhancer starr_08530 Neighboring gene predicted gene, 32900 Neighboring gene VISTA enhancer mm1505 Neighboring gene STARR-seq mESC enhancer starr_08533 Neighboring gene STARR-seq mESC enhancer starr_08536 Neighboring gene STARR-seq mESC enhancer starr_08538 Neighboring gene STARR-seq mESC enhancer starr_08539 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101298216-101298417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101301424-101301635 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101306075-101306330 Neighboring gene STARR-seq mESC enhancer starr_08540 Neighboring gene predicted gene, 40109 Neighboring gene predicted gene, 33162

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis. Usardi A, et al. Dev Neurobiol, 2017 Jan. PMID 27328461
  2. Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice. Penha-Gonçalves C, et al. Diabetes, 2003 Jun. PMID 12765969
  3. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization. Tanjore Ramanathan J, et al. Sci Rep, 2023 Oct 11. PMID 37821496, Free PMC Article
  4. Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10. Yamaji K, et al. Biochem Biophys Res Commun, 2005 Jun 3. PMID 15850792
  5. Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Pan Y, et al. Sci Rep, 2016 Oct 24. PMID 27775065, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
    Title: Immunoglobulin superfamily member 3 is required for the vagal neural crest cell migration and enteric neuronal network organization.
  2. IGSF3 is a novel regulator of neuronal morphogenesis that might function through interactions with multiple partners.
    Title: The immunoglobulin-like superfamily member IGSF3 is a developmentally regulated protein that controls neuronal morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lacrimal gland development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
immunoglobulin superfamily member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404406.1 → NP_001391335.1  immunoglobulin superfamily member 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131184

  2. NM_001404407.1 → NP_001391336.1  immunoglobulin superfamily member 3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC131184
    UniProtKB/TrEMBL
    A0A0A6YX40
    Related
    ENSMUSP00000141823.2, ENSMUST00000195164.2

  3. NM_001404408.1 → NP_001391337.1  immunoglobulin superfamily member 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131184

  4. NM_207205.3 → NP_997088.2  immunoglobulin superfamily member 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_997088.2

    Status: VALIDATED

    Source sequence(s)
    AC131184
    Consensus CDS
    CCDS17682.1
    UniProtKB/Swiss-Prot
    A0A4X9, Q6ZQA6, Q7TPV3
    Related
    ENSMUSP00000048900.6, ENSMUST00000043983.11
    Conserved Domains (3) summary
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07686
    Location:687 → 784
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101284306..101370375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502343.5 → XP_006502406.1  immunoglobulin superfamily member 3 isoform X1

    See identical proteins and their annotated locations for XP_006502406.1

    UniProtKB/TrEMBL
    A0A0A6YX40
    Conserved Domains (3) summary
    smart00409
    Location:293 → 389
    IG; Immunoglobulin
    pfam07686
    Location:707 → 804
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain

  2. XM_030252915.2 → XP_030108775.1  immunoglobulin superfamily member 3 isoform X3

    UniProtKB/Swiss-Prot
    A0A4X9, Q6ZQA6, Q7TPV3
    Conserved Domains (3) summary
    smart00410
    Location:293 → 389
    IG_like; Immunoglobulin like
    pfam07686
    Location:687 → 784
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:162 → 256
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZQA6.2 GenPept UniProtKB/Swiss-Prot:Q6ZQA6

Gene LinkOut

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