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ROP16 rhoptry protein ROP16 [ Toxoplasma gondii ME49 ]

Gene ID: 7894782, updated on 17-May-2024

Summary

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Gene symbol
ROP16
Gene description
rhoptry protein ROP16
Locus tag
TGME49_262730
See related
ToxoDB:TGME49_262730; VEuPathDB:TGME49_262730
Gene type
protein coding
RNA name
rhoptry protein ROP16
RefSeq status
PROVISIONAL
Organism
Toxoplasma gondii ME49 (strain: ME49)
Lineage
Eukaryota; Alveolata; Apicomplexa; Conoidasida; Coccidia; Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma
Old locus tag
TGME49_062730
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Genomic context

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Location:
chromosome: VIIb
Exon count:
1
Sequence:
Chromosome: VIIb; NC_031475.1 (1053320..1056333, complement)

Chromosome VIIb - NC_031475.1Genomic Context describing neighboring genes Neighboring gene histone lysine methyltransferase, SET, putative Neighboring gene hypothetical protein Neighboring gene eukaryotic initiation factor-1A, putative Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_031475.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis. Rochet E, et al. PLoS One, 2019. PMID 30901349, Free PMC Article
  2. Recombinant canine adenovirus type-2 expressing TgROP16 provides partial protection against acute Toxoplasma gondii infection in mice. Li XZ, et al. Infect Genet Evol, 2016 Nov. PMID 27742446
  3. Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16. Fan W, et al. Mol Med Rep, 2016 Nov. PMID 27666388, Free PMC Article
  4. Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways. Sabou M, et al. Cell Mol Life Sci, 2020 Jun. PMID 31492965, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reports a new parasite persistence strategy involving T. gondii rhoptry protein ROP16 secreted early during invasion, which targets the transcription factor UHRF1 (ubiquitin-like containing PHD and RING fingers domain 1), and leads to host cell cycle arrest.
    Title: Toxoplasma gondii ROP16 kinase silences the cyclin B1 gene promoter by hijacking host cell UHRF1-dependent epigenetic pathways.
  2. Results show that the ROP16 allele has profound influence on retinal pathology, apparently independent on control of intraocular parasite multiplication in a mouse mode of ocular toxoplasmosis.
    Title: Type I ROP16 regulates retinal inflammatory responses during ocular toxoplasmosis.
  3. A novel recombinant canine adenovirus type 2 expressing ROP16 (CAV-2-ROP16) of T. gondii was constructed. MDCK cells were used to assess expression of ROP16 after transfection with CAV-2-ROP16. CAV-2-ROP16 immunization in mice elicited an extremely efficient humoral and cellular immune response with significantly improved toxoplasmosis survival rate compared with control.
    Title: Recombinant canine adenovirus type-2 expressing TgROP16 provides partial protection against acute Toxoplasma gondii infection in mice.
  4. these results may contribute to understanding the mechanisms underlying the functions of ROP16 and provide scope for further investigation of the pathogenesis of Toxoplasma gondii.
    Title: Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
rhoptry protein ROP16
XP_002365373.1
  • encoded by transcript TGME49_262730
    Signal peptide predicted by SignalP 2.0 HMM (probability 0.973) with cleavage site probability 0.661 at residue 23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_031475.1 Reference assembly

    Range
    1053320..1056333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002365332.1 → XP_002365373.1  rhoptry protein ROP16 [Toxoplasma gondii ME49]

    See identical proteins and their annotated locations for XP_002365373.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0N5EBG9, A0A125YY08, B6KC39, D8UWB7, Q3YJR5, S8F1Q0
    Conserved Domains (1) summary
    cl21453
    Location:517 → 627
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version

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