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Mrs2 magnesium transporter MRS2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79032, updated on 10-Jul-2024

Summary

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Official Symbol
Mrs2provided by RGD
Official Full Name
magnesium transporter MRS2provided by RGD
Primary source
RGD:708529
See related
EnsemblRapid:ENSRNOG00000017545 AllianceGenome:RGD:708529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpt; Mrs2l
Summary
Predicted to enable magnesium ion transmembrane transporter activity. Involved in lactate metabolic process. Located in mitochondrial inner membrane. Used to study demyelinating disease. Orthologous to human MRS2 (magnesium transporter MRS2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 131.4), Heart (RPKM 129.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrs2 in Genome Data Viewer
Location:
17p11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (40491963..40515116)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (40063924..40087073)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (42064271..42083602)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482709 Neighboring gene doublecortin domain containing 2 Neighboring gene ribosomal protein L32, pseudogene 10 Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene aldehyde dehydrogenase 5 family, member A1 Neighboring gene KIAA0319 homolog Neighboring gene ribosomal protein L37, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect. Kuwamura M, et al. Brain Res, 2019 Sep 1. PMID 31100216
  2. A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat. Kuramoto T, et al. PLoS Genet, 2011 Jan 6. PMID 21253565, Free PMC Article
  3. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. Piskacek M, et al. J Cell Mol Med, 2009 Apr. PMID 18384665, Free PMC Article
  4. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Zsurka G, et al. Genomics, 2001 Mar 1. PMID 11401429
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.
    Title: Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect.
  2. transgenic rats showed that MRS2 was dominantly expressed in neurons rather than oligodendrocytes and was ultrastructurally observed in the inner membrane of mitochondria
    Title: A mutation in the gene encoding mitochondrial Mg²+ channel MRS2 results in demyelination in the rat.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93415

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lactate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial magnesium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial magnesium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial magnesium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
magnesium transporter MRS2 homolog, mitochondrial
Names
MRS2 magnesium homeostasis factor homolog
MRS2 magnesium transporter
MRS2-like protein
MRS2-like, magnesium homeostasis factor
RPT protein similar to yeast MRS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024001.1 → NP_076491.1  magnesium transporter MRS2 homolog, mitochondrial precursor

    See identical proteins and their annotated locations for NP_076491.1

    Status: PROVISIONAL

    Source sequence(s)
    AF288289
    UniProtKB/Swiss-Prot
    Q4FZY6, Q5XIW5, Q9ET07, Q9ET08, Q9ET09
    UniProtKB/TrEMBL
    A0A8I6A5Y1, A6KLE4
    Related
    ENSRNOP00000023787.5, ENSRNOT00000023787.7
    Conserved Domains (1) summary
    cd12823
    Location:79 → 390
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    40491963..40515116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253937.5 → XP_006253999.1  magnesium transporter MRS2 homolog, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5Y1
    Conserved Domains (1) summary
    cd12823
    Location:79 → 390
    Mrs2_Mfm1p-like; Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family

  2. XM_039096094.2 → XP_038952022.1  magnesium transporter MRS2 homolog, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00459
    Location:79 → 249
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily

RNA

  1. XR_010058955.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ET09.1 GenPept UniProtKB/Swiss-Prot:Q9ET09

Gene LinkOut

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