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ZFYVE21 zinc finger FYVE-type containing 21 [ Homo sapiens (human) ]

Gene ID: 79038, updated on 2-Nov-2024

Summary

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Official Symbol
ZFYVE21provided by HGNC
Official Full Name
zinc finger FYVE-type containing 21provided by HGNC
Primary source
HGNC:HGNC:20760
See related
Ensembl:ENSG00000100711 MIM:613504; AllianceGenome:HGNC:20760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF21; HCVP7TP1
Summary
Predicted to enable metal ion binding activity. Predicted to be located in endosome and focal adhesion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 36.0), endometrium (RPKM 31.2) and 25 other tissues See more
Orthologs
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Genomic context

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See ZFYVE21 in Genome Data Viewer
Location:
14q32.33
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103715810..103733664)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97951867..97969731)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104182147..104200001)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9109 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104106328-104106828 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6168 Neighboring gene kinesin light chain 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104140157-104140656 Neighboring gene MPRA-validated peak2255 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172251-104172810 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104172811-104173372 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104180589-104181274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104184511-104185021 Neighboring gene X-ray repair cross complementing 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104187639-104188139 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104209353-104210134 Neighboring gene protein phosphatase 1 regulatory subunit 13B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104260985-104261486 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:104261487-104261986 Neighboring gene small nucleolar RNA SNORD51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6179 Neighboring gene PPP1R13B divergent transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZF21 protein regulates cell adhesion and motility. Nagano M, et al. J Biol Chem, 2010 Jul 2. PMID 20439989, Free PMC Article
  2. ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes. Fang C, et al. Nat Commun, 2019 May 21. PMID 31113953, Free PMC Article
  3. The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia. Hoshino D, et al. PLoS One, 2013. PMID 23382803, Free PMC Article
  4. ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain. Nagano M, et al. J Biol Chem, 2011 Sep 9. PMID 21768110, Free PMC Article
  5. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging. Jiang Q, et al. Kidney Int, 2024 Sep. PMID 38797325,

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
    Title: ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.
  2. ZFYVE21 is identified as a posttranslationally induced Rab5 effector that triggers phosphoinositide remodeling of early endosome membranes to mediate non-canonical NF-kappaB signal activation and tissue inflammation.
    Title: ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.
  3. this study demonstrates that ZF21 is a key player regulating multiple aspects of cancer cell migration and invasion.
    Title: The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.
  4. the C-terminal region is important for the ability of ZF21 to induce disassembly of FAs and cell migration
    Title: ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.
  5. ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center. We identified 45 proteins including FA-related proteins and multiple RNA binding proteins
    Title: ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.
  6. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2550

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 21
Names
FYVE domain containing 21
HCV p7-transactivated protein 1
zinc finger, FYVE domain containing 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198953.2 → NP_001185882.1  zinc finger FYVE domain-containing protein 21 isoform 1

    See identical proteins and their annotated locations for NP_001185882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK057816, AL049840, CA311020, CX786145
    Consensus CDS
    CCDS55948.1
    UniProtKB/Swiss-Prot
    Q9BQ24
    Related
    ENSP00000216602.6, ENST00000216602.10
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 247
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

  2. NM_024071.4 → NP_076976.1  zinc finger FYVE domain-containing protein 21 isoform 2

    See identical proteins and their annotated locations for NP_076976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC005999, CA311020
    Consensus CDS
    CCDS9985.1
    UniProtKB/Swiss-Prot
    A8K3A4, Q86T05, Q96LT1, Q9BQ24
    Related
    ENSP00000310543.2, ENST00000311141.7
    Conserved Domains (2) summary
    cd15727
    Location:38 → 101
    FYVE_ZF21; FYVE domain found in zinc finger FYVE domain-containing protein 21 (ZF21) and similar proteins
    pfam16696
    Location:108 → 229
    ZFYVE21_C; Zinc finger FYVE domain-containing protein 21 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103715810..103733664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97951867..97969731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQ24.1 GenPept UniProtKB/Swiss-Prot:Q9BQ24

Gene LinkOut

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Chemical Information
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