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TRPM8 transient receptor potential cation channel subfamily M member 8 [ Homo sapiens (human) ]

Gene ID: 79054, updated on 2-Nov-2024

Summary

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Official Symbol
TRPM8provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily M member 8provided by HGNC
Primary source
HGNC:HGNC:17961
See related
Ensembl:ENSG00000144481 MIM:606678; AllianceGenome:HGNC:17961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRPP8; LTRPC6; trp-p8; LTrpC-6
Summary
Predicted to enable ligand-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including intracellular calcium ion homeostasis; response to cold; and thermoception. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward prostate (RPKM 48.0) See more
Orthologs
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Genomic context

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See TRPM8 in Genome Data Viewer
Location:
2q37.1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (233917373..234019522)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (234406317..234508483)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (234826018..234928166)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:234759038-234759538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:234763063-234764055 Neighboring gene Holliday junction recognition protein Neighboring gene MSL complex subunit 3B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:234882993-234884192 Neighboring gene Sharpr-MPRA regulatory region 7512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17351 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:234920120-234920398 Neighboring gene secreted phosphoprotein 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:235066116-235066288 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:235072133-235073332 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:235077257-235077756 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:235079950-235080452 Neighboring gene uncharacterized LOC105373932

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. Valero ML, et al. PLoS One, 2012. PMID 23251635, Free PMC Article
  2. [Respiratory system response to cooling in subjects with single nucleotide polymorphism rs11562975 in gene of thermosensitive TRPM8 ion channel]. Kozyreva TV, et al. Fiziol Cheloveka, 2014 Mar-Apr. PMID 25272712
  3. Over-expression of TRPM8 is associated with poor prognosis in urothelial carcinoma of bladder. Xiao N, et al. Tumour Biol, 2014 Nov. PMID 25128062
  4. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. Winchester WJ, et al. J Pharmacol Exp Ther, 2014 Nov. PMID 25125580
  5. TRPM8. Almaraz L, et al. Handb Exp Pharmacol, 2014. PMID 24756721

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Implications of TRPM3 and TRPM8 for sensory neuron sensitisation.
    Title: Implications of TRPM3 and TRPM8 for sensory neuron sensitisation.
  2. TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway.
    Title: TRPM8 overexpression suppresses hepatocellular carcinoma progression and improves survival by modulating the RTP3/STAT3 pathway.
  3. Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs.
    Title: Neuregulin 1 mitigated prolactin deficiency through enhancing TRPM8 signaling under the influence of melatonin in senescent pituitary lactotrophs.
  4. Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.
    Title: Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets.
  5. Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.
    Title: Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer.
  6. Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.
    Title: Joint CB1 and NGF Receptor Activation Suppresses TRPM8 Activation in Etoposide-Resistant Retinoblastoma Cells.
  7. TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
    Title: TCAF2 in Pericytes Promotes Colorectal Cancer Liver Metastasis via Inhibiting Cold-Sensing TRPM8 Channel.
  8. Structure of human TRPM8 channel.
    Title: Structure of human TRPM8 channel.
  9. TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing.
    Title: TRPM8 as a Potential Biomarker and Therapeutic Target for Gastric Cancer Identified by a Combination of Text Mining and RNA Sequencing.
  10. Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
    Title: Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.
Submit: New GeneRIF Correction See all GeneRIFs (167)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of behavioral disinhibition.
EBI GWAS Catalog
Genome-wide association analysis identifies susceptibility loci for migraine without aura.
EBI GWAS Catalog
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
EBI GWAS Catalog
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC2849

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables ligand-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to cold IEA
Inferred from Electronic Annotation
more info
  
involved_in thermoception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transient receptor potential cation channel subfamily M member 8
Names
TRPM8 cationic channel
transient receptor potential p8
transient receptor potential subfamily M member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397606.1 → NP_001384535.1  transient receptor potential cation channel subfamily M member 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005538

  2. NM_001397607.1 → NP_001384536.1  transient receptor potential cation channel subfamily M member 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z857
    Conserved Domains (2) summary
    TIGR00870
    Location:607 → 955
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:66 → 337
    LSDAT_euk; SLOG in TRPM

  3. NM_001397608.1 → NP_001384537.1  transient receptor potential cation channel subfamily M member 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC005538

  4. NM_001397609.1 → NP_001384538.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z836
    Conserved Domains (2) summary
    TIGR00870
    Location:580 → 928
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:39 → 310
    LSDAT_euk; SLOG in TRPM

  5. NM_001397610.1 → NP_001384539.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z836
    Conserved Domains (2) summary
    TIGR00870
    Location:580 → 928
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:39 → 310
    LSDAT_euk; SLOG in TRPM

  6. NM_001397611.1 → NP_001384540.1  transient receptor potential cation channel subfamily M member 8 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z836
    Conserved Domains (2) summary
    TIGR00870
    Location:580 → 928
    trp; transient-receptor-potential calcium channel protein
    cl39032
    Location:39 → 310
    LSDAT_euk; SLOG in TRPM

  7. NM_001397612.1 → NP_001384541.1  transient receptor potential cation channel subfamily M member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005538

  8. NM_001397613.1 → NP_001384542.1  transient receptor potential cation channel subfamily M member 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC005538

  9. NM_001397614.1 → NP_001384543.1  transient receptor potential cation channel subfamily M member 8 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z856
    Conserved Domains (1) summary
    TIGR00870
    Location:262 → 610
    trp; transient-receptor-potential calcium channel protein

  10. NM_001397615.1 → NP_001384544.1  transient receptor potential cation channel subfamily M member 8 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z856
    Conserved Domains (1) summary
    TIGR00870
    Location:262 → 610
    trp; transient-receptor-potential calcium channel protein

  11. NM_001397617.1 → NP_001384546.1  transient receptor potential cation channel subfamily M member 8 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z853
    Conserved Domains (1) summary
    TIGR00870
    Location:41 → 205
    trp; transient-receptor-potential calcium channel protein

  12. NM_001397619.1 → NP_001384548.1  transient receptor potential cation channel subfamily M member 8 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z878
    Conserved Domains (1) summary
    TIGR00870
    Location:262 → 610
    trp; transient-receptor-potential calcium channel protein

  13. NM_001397620.1 → NP_001384549.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z860
    Conserved Domains (1) summary
    TIGR00870
    Location:41 → 205
    trp; transient-receptor-potential calcium channel protein

  14. NM_001397621.1 → NP_001384550.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z860
    Conserved Domains (1) summary
    TIGR00870
    Location:41 → 205
    trp; transient-receptor-potential calcium channel protein

  15. NM_001397622.1 → NP_001384551.1  transient receptor potential cation channel subfamily M member 8 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z860
    Conserved Domains (1) summary
    TIGR00870
    Location:41 → 205
    trp; transient-receptor-potential calcium channel protein

  16. NM_001397623.1 → NP_001384552.1  transient receptor potential cation channel subfamily M member 8 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC005538

  17. NM_001397624.1 → NP_001384553.1  transient receptor potential cation channel subfamily M member 8 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC005538

  18. NM_001397625.1 → NP_001384554.1  transient receptor potential cation channel subfamily M member 8 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC005538
    UniProtKB/TrEMBL
    A0A1L1Z866
    Conserved Domains (1) summary
    TIGR00870
    Location:41 → 205
    trp; transient-receptor-potential calcium channel protein

  19. NM_001397626.1 → NP_001384555.1  transient receptor potential cation channel subfamily M member 8 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC005538

  20. NM_001397627.1 → NP_001384556.1  transient receptor potential cation channel subfamily M member 8 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC005538
    Consensus CDS
    CCDS92975.1
    UniProtKB/TrEMBL
    A0A0C4DFT0
    Related
    ENSP00000347956.4, ENST00000355722.8
    Conserved Domains (1) summary
    cl39032
    Location:66 → 177
    LSDAT_euk; SLOG in TRPM

  21. NM_001397628.1 → NP_001384557.1  transient receptor potential cation channel subfamily M member 8 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005538
    Consensus CDS
    CCDS92976.1
    UniProtKB/TrEMBL
    A0A1L1Z822
    Conserved Domains (1) summary
    cl39032
    Location:39 → 150
    LSDAT_euk; SLOG in TRPM

  22. NM_001397629.1 → NP_001384558.1  transient receptor potential cation channel subfamily M member 8 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005538
    Consensus CDS
    CCDS92976.1
    UniProtKB/TrEMBL
    A0A1L1Z822
    Related
    ENSP00000386771.1, ENST00000409625.1
    Conserved Domains (1) summary
    cl39032
    Location:39 → 150
    LSDAT_euk; SLOG in TRPM

  23. NM_001397630.1 → NP_001384559.1  transient receptor potential cation channel subfamily M member 8 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC005538
    Consensus CDS
    CCDS92976.1
    UniProtKB/TrEMBL
    A0A1L1Z822
    Conserved Domains (1) summary
    cl39032
    Location:39 → 150
    LSDAT_euk; SLOG in TRPM

  24. NM_001397635.1 → NP_001384564.1  transient receptor potential cation channel subfamily M member 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC005538

  25. NM_024080.5 → NP_076985.4  transient receptor potential cation channel subfamily M member 8 isoform 1

    See identical proteins and their annotated locations for NP_076985.4

    Status: VALIDATED

    Source sequence(s)
    AC005538, AY090109, BC001135, BC033137
    Consensus CDS
    CCDS33407.1
    UniProtKB/Swiss-Prot
    A0AVG2, Q3YFM7, Q6QNH9, Q7Z2W7, Q8TAC3, Q8TDX8, Q9BVK1
    UniProtKB/TrEMBL
    A0A1L1Z843, W8DTH1
    Related
    ENSP00000323926.4, ENST00000324695.9
    Conserved Domains (1) summary
    pfam00520
    Location:756 → 989
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    233917373..234019522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511810.3 → XP_011510112.1  transient receptor potential cation channel subfamily M member 8 isoform X1

    UniProtKB/TrEMBL
    A0A1L1Z843
    Conserved Domains (1) summary
    pfam00520
    Location:756 → 989
    Ion_trans; Ion transport protein

  2. XM_017004891.1 → XP_016860380.1  transient receptor potential cation channel subfamily M member 8 isoform X2

    UniProtKB/TrEMBL
    A0A1L1Z852

  3. XM_024453133.2 → XP_024308901.1  transient receptor potential cation channel subfamily M member 8 isoform X3

    Conserved Domains (1) summary
    cl26777
    Location:262 → 610
    TRP_2; Transient receptor ion channel II

  4. XM_047445804.1 → XP_047301760.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    UniProtKB/TrEMBL
    A0A1L1Z853
    Related
    ENSP00000414198.1, ENST00000456930.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    234406317..234508483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343843.1 → XP_054199818.1  transient receptor potential cation channel subfamily M member 8 isoform X1

  2. XM_054343844.1 → XP_054199819.1  transient receptor potential cation channel subfamily M member 8 isoform X2

  3. XM_054343845.1 → XP_054199820.1  transient receptor potential cation channel subfamily M member 8 isoform X3

  4. XM_054343846.1 → XP_054199821.1  transient receptor potential cation channel subfamily M member 8 isoform X4

    UniProtKB/TrEMBL
    A0A1L1Z853
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z2W7.2 GenPept UniProtKB/Swiss-Prot:Q7Z2W7

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