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PWRN2 Prader-Willi region non-protein coding RNA 2 [ Homo sapiens (human) ]

Gene ID: 791115, updated on 10-Oct-2023

Summary

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Official Symbol
PWRN2provided by HGNC
Official Full Name
Prader-Willi region non-protein coding RNA 2provided by HGNC
Primary source
HGNC:HGNC:33236
See related
Ensembl:ENSG00000260551 MIM:611217; AllianceGenome:HGNC:33236
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRNA00199
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Genomic context

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Location:
15q11.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (24164777..24169948, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (21898852..21904023, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (24409924..24415095, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24199761-24200274 Neighboring gene uncharacterized LOC107984787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:24200275-24200786 Neighboring gene Prader-Willi region non-protein coding RNA 4 Neighboring gene uncharacterized LOC105370733 Neighboring gene uncharacterized LOC105370732 Neighboring gene uncharacterized LOC102723749 Neighboring gene uncharacterized LOC102725165

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration. Yu X, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33340764
  2. LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis. Xin CH, et al. Eur Rev Med Pharmacol Sci, 2020 Oct. PMID 33090407
  3. Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS. Huang X, et al. Reprod Biol Endocrinol, 2018 Aug 3. PMID 30075721, Free PMC Article
  4. Precise microdeletion detection of Prader-Willi Syndrome with array comparative genome hybridization. Shao XY, et al. Biomed Environ Sci, 2010 Jun. PMID 20708498
  5. C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain. Buiting K, et al. Genomics, 2007 May. PMID 17337158

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis.
    Title: LncRNA PWRN2 stimulates the proliferation and migration in papillary thyroid carcinoma through the miR-325/DDX5 axis.
  2. Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
    Title: Long non-coding RNA PWRN2 regulates cytotoxicity in an in vitro model of age-related macular degeneration.
  3. Prader-Willi region nonprotein coding RNA 2 (PWRN2) was found to be associated with oocyte nuclear maturation in patients with polycystic ovary syndrome (PCOS) in contrast to that in normal patients.
    Title: Construction and analysis of a lncRNA (PWRN2)-mediated ceRNA network reveal its potential roles in oocyte nuclear maturation of patients with PCOS.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Clone Names

  • FLJ42137

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_152824.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087474
    Related
    ENST00000567246.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    24164777..24169948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    5112475..5117648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    21898852..21904023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_026647.1: Suppressed sequence

    Description
    NR_026647.1: This RefSeq was removed because currently there is insufficient support for this transcript.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases