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Begain brain-enriched guanylate kinase-associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 79146, updated on 10-Jul-2024

Summary

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Official Symbol
Begainprovided by RGD
Official Full Name
brain-enriched guanylate kinase-associatedprovided by RGD
Primary source
RGD:708347
See related
EnsemblRapid:ENSRNOG00000004650 AllianceGenome:RGD:708347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of postsynaptic neurotransmitter receptor activity. Predicted to act upstream of or within evoked excitatory postsynaptic potential. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Is active in glutamatergic synapse and postsynapse. Orthologous to human BEGAIN (brain enriched guanylate kinase associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 32.4), Lung (RPKM 6.3) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Begain in Genome Data Viewer
Location:
6q32
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133708010..133744264, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127943651..127979876, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132936964..132972569, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tryptophanyl-tRNA synthetase 1 Neighboring gene WD repeat domain 25 Neighboring gene ribosomal protein S18, pseudogene 3 Neighboring gene uncharacterized LOC102555774 Neighboring gene uncharacterized LOC120103622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein. Yao I, et al. J Neurosci, 2002 Jul 1. PMID 12097487, Free PMC Article
  2. Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. Katano T, et al. eNeuro, 2016 Sep-Oct. PMID 27785460, Free PMC Article
  3. BEGAIN (brain-enriched guanylate kinase-associated protein), a novel neuronal PSD-95/SAP90-binding protein. Deguchi M, et al. J Biol Chem, 1998 Oct 9. PMID 9756850
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within evoked excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
brain-enriched guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111115.1 → NP_001104585.1  brain-enriched guanylate kinase-associated protein isoform 1

    See identical proteins and their annotated locations for NP_001104585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate 5'-terminal coding exon, compared to variant 2, resulting in a shorter protein (isoform 1) that has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AF064868, AF064869, BP478305, CB801805
    UniProtKB/TrEMBL
    A0A0G2K0E5, A6KBJ0
    Conserved Domains (1) summary
    cl12013
    Location:35 → 152
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_024163.2 → NP_077077.1  brain-enriched guanylate kinase-associated protein isoform 2

    See identical proteins and their annotated locations for NP_077077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AF064868, BP478305
    UniProtKB/Swiss-Prot
    O88881, O88882
    UniProtKB/TrEMBL
    A0A0G2K0E5, A6KBI9
    Related
    ENSRNOP00000100911.1, ENSRNOT00000152282.1
    Conserved Domains (1) summary
    cl12013
    Location:41 → 158
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    133708010..133744264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262544.1 → XP_063118614.1  brain-enriched guanylate kinase-associated protein isoform X12

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000104689.1, ENSRNOT00000168582.1

  2. XM_039112985.2 → XP_038968913.1  brain-enriched guanylate kinase-associated protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000099634.1, ENSRNOT00000161251.1
    Conserved Domains (1) summary
    COG1196
    Location:21 → 143
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_039112981.2 → XP_038968909.1  brain-enriched guanylate kinase-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Conserved Domains (1) summary
    COG1196
    Location:54 → 172
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  4. XM_017594386.3 → XP_017449875.2  brain-enriched guanylate kinase-associated protein isoform X7

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000099151.1, ENSRNOT00000158669.1
    Conserved Domains (2) summary
    COG1196
    Location:54 → 172
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:574 → 640
    Pilt; Protein incorporated later into Tight Junctions

  5. XM_063262545.1 → XP_063118615.1  brain-enriched guanylate kinase-associated protein isoform X1

    UniProtKB/TrEMBL
    A6KBJ1

  6. XM_039112988.2 → XP_038968916.1  brain-enriched guanylate kinase-associated protein isoform X8

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Conserved Domains (1) summary
    COG1196
    Location:2 → 124
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  7. XM_039112987.2 → XP_038968915.1  brain-enriched guanylate kinase-associated protein isoform X6

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Conserved Domains (1) summary
    COG1196
    Location:4 → 137
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  8. XM_039112984.2 → XP_038968912.2  brain-enriched guanylate kinase-associated protein isoform X3

    UniProtKB/TrEMBL
    A0A0G2K0E5

  9. XM_063262542.1 → XP_063118612.1  brain-enriched guanylate kinase-associated protein isoform X10

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000071412.3, ENSRNOT00000082216.3

  10. XM_039112986.2 → XP_038968914.1  brain-enriched guanylate kinase-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Conserved Domains (1) summary
    COG1196
    Location:19 → 141
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  11. XM_063262543.1 → XP_063118613.1  brain-enriched guanylate kinase-associated protein isoform X11

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000102527.1, ENSRNOT00000140322.1

  12. XM_063262540.1 → XP_063118610.1  brain-enriched guanylate kinase-associated protein isoform X8

    UniProtKB/TrEMBL
    A0A0G2K0E5
    Related
    ENSRNOP00000049699.4, ENSRNOT00000041903.7

  13. XM_063262539.1 → XP_063118609.1  brain-enriched guanylate kinase-associated protein isoform X1

    UniProtKB/TrEMBL
    A6KBJ1

  14. XM_063262541.1 → XP_063118611.1  brain-enriched guanylate kinase-associated protein isoform X9

    UniProtKB/TrEMBL
    A6KBJ1

  15. XM_039112990.2 → XP_038968918.1  brain-enriched guanylate kinase-associated protein isoform X1

    UniProtKB/TrEMBL
    A6KBJ1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88881.1 GenPept UniProtKB/Swiss-Prot:O88881

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