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Gucy2d guanylate cyclase 2D, retinal [ Rattus norvegicus (Norway rat) ]

Gene ID: 79222, updated on 28-Oct-2024

Summary

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Official Symbol
Gucy2dprovided by RGD
Official Full Name
guanylate cyclase 2D, retinalprovided by RGD
Primary source
RGD:620438
See related
EnsemblRapid:ENSRNOG00000007931 AllianceGenome:RGD:620438
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gucy2e; RETGC-1
Summary
Enables guanylate cyclase activity and protein homodimerization activity. Involved in cGMP-mediated signaling. Located in photoreceptor outer segment membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 3.6), Lung (RPKM 1.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gucy2d in Genome Data Viewer
Location:
10q24
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (54453753..54478639, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (53954918..53975576, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (55835695..55851235, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 15-lipoxygenase, type B Neighboring gene U6 spliceosomal RNA Neighboring gene centrobin, centriole duplication and spindle assembly protein Neighboring gene trafficking protein particle complex subunit 1 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Photoreceptor Guanylate Cyclase (GUCY2D) Mutations Cause Retinal Dystrophies by Severe Malfunction of Ca(2+)-Dependent Cyclic GMP Synthesis. Wimberg H, et al. Front Mol Neurosci, 2018. PMID 30319355, Free PMC Article
  2. Clustering and frequency of mutations in the retinal guanylate cyclase (GUCY2D) gene in patients with dominant cone-rod dystrophies. Payne AM, et al. J Med Genet, 2001 Sep. PMID 11565546, Free PMC Article
  3. Two membrane forms of guanylyl cyclase found in the eye. Yang RB, et al. Proc Natl Acad Sci U S A, 1995 Jan 17. PMID 7831337, Free PMC Article
  4. The human photoreceptor membrane guanylyl cyclase, RetGC, is present in outer segments and is regulated by calcium and a soluble activator. Dizhoor AM, et al. Neuron, 1994 Jun. PMID 7912093
  5. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. Yang RB, et al. J Biol Chem, 1997 May 23. PMID 9153227

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cGMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cGMP-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in receptor guanylyl cyclase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor outer segment membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor outer segment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
retinal guanylyl cyclase 1
Names
guanylate cyclase 2D, membrane (retina-specific)
guanylate cyclase 2E
guanylyl cyclase 2e
guanylyl cyclase GC-E
NP_077356.1
XP_038942841.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024380.1 → NP_077356.1  retinal guanylyl cyclase 1 precursor

    See identical proteins and their annotated locations for NP_077356.1

    Status: PROVISIONAL

    Source sequence(s)
    L36029
    UniProtKB/Swiss-Prot
    P51840
    UniProtKB/TrEMBL
    A6HFP3, V9GZ79
    Related
    ENSRNOP00000010790.5, ENSRNOT00000010790.6
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1039
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:540 → 814
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    cd06371
    Location:58 → 434
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:823 → 868
    HNOBA; Heme NO binding associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    54453753..54478639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086913.2 → XP_038942841.1  retinal guanylyl cyclase 1 isoform X1

    UniProtKB/Swiss-Prot
    P51840
    UniProtKB/TrEMBL
    A6HFP3, V9GZ79
    Conserved Domains (4) summary
    smart00044
    Location:848 → 1039
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    cd14043
    Location:540 → 814
    PK_GC-2D; Pseudokinase domain of the membrane Guanylate Cyclase receptor, GC-2D
    cd06371
    Location:58 → 434
    PBP1_sensory_GC_DEF-like; ligand-binding domain of membrane guanylyl cyclases (GC-D, GC-E, and GC-F) that are specifically expressed in sensory tissues
    pfam07701
    Location:823 → 868
    HNOBA; Heme NO binding associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51840.1 GenPept UniProtKB/Swiss-Prot:P51840

Gene LinkOut

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