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Luzp1 leucine zipper protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 79428, updated on 17-Aug-2024

Summary

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Official Symbol
Luzp1provided by RGD
Official Full Name
leucine zipper protein 1provided by RGD
Primary source
RGD:61839
See related
EnsemblRapid:ENSRNOG00000022402 AllianceGenome:RGD:61839
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Luzp
Summary
Predicted to be involved in neural fold bending. Predicted to act upstream of or within artery development and ventricular septum development. Predicted to be located in nucleus. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 107.0), Kidney (RPKM 99.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153989570..154065071)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148706094..148781616)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154831697..154907646)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103181 Neighboring gene 5-hydroxytryptamine receptor 1D Neighboring gene aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like Neighboring gene lysine demethylase 1A Neighboring gene uncharacterized LOC120103012 Neighboring gene testis expressed 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. Lee MW, et al. J Biomed Sci, 2001 Nov-Dec. PMID 11702014
  2. LUZP deficiency affects neural tube closure during brain development. Hsu CY, et al. Biochem Biophys Res Commun, 2008 Nov 21. PMID 18801334
  3. Identification, molecular characterization, and chromosomal localization of the cDNA encoding a novel leucine zipper motif-containing protein. Sun DS, et al. Genomics, 1996 Aug 15. PMID 8812416
  4. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in artery development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within artery development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural fold bending IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural fold bending IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural fold bending ISO
Inferred from Sequence Orthology
more info
  
involved_in ventricular septum development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ventricular septum development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
leucine zipper protein 1
Names
leucine zipper motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030830.2 → NP_110457.2  leucine zipper protein 1

    See identical proteins and their annotated locations for NP_110457.2

    Status: VALIDATED

    Source sequence(s)
    CH473968
    UniProtKB/Swiss-Prot
    Q9ESV1
    UniProtKB/TrEMBL
    A6ITB5, G3V7L9
    Related
    ENSRNOP00000016514.2, ENSRNOT00000016093.5
    Conserved Domains (1) summary
    COG1196
    Location:10 → 348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153989570..154065071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239274.5 → XP_006239336.1  leucine zipper protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006239336.1

    UniProtKB/Swiss-Prot
    Q9ESV1
    UniProtKB/TrEMBL
    A6ITB5, G3V7L9
    Conserved Domains (1) summary
    COG1196
    Location:10 → 348
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_063288465.1 → XP_063144535.1  leucine zipper protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESV1
    UniProtKB/TrEMBL
    A6ITB5, G3V7L9

  3. XM_063288466.1 → XP_063144536.1  leucine zipper protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ESV1
    UniProtKB/TrEMBL
    A6ITB5, G3V7L9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ESV1.1 GenPept UniProtKB/Swiss-Prot:Q9ESV1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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