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Alcam activated leukocyte cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 79559, updated on 10-Jul-2024

Summary

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Official Symbol
Alcamprovided by RGD
Official Full Name
activated leukocyte cell adhesion moleculeprovided by RGD
Primary source
RGD:619972
See related
EnsemblRapid:ENSRNOG00000001989 AllianceGenome:RGD:619972
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in axon extension involved in axon guidance; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and retinal ganglion cell axon guidance. Predicted to act upstream of or within motor neuron axon guidance. Predicted to be located in several cellular components, including external side of plasma membrane; immunological synapse; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 640.6), Brain (RPKM 308.4) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alcam in Genome Data Viewer
Location:
11q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (61804932..62005250)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (48336123..48536296)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (50780735..50985083)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene clusterin associated protein 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134480990 Neighboring gene Cbl proto-oncogene B Neighboring gene uncharacterized LOC134480987 Neighboring gene uncharacterized LOC100912248

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn. Park ES, et al. Neurosci Lett, 2017 Aug 24. PMID 28720382
  2. Activated leukocyte cell adhesion molecule modulates neurotrophin signaling. Wade A, et al. J Neurochem, 2012 May. PMID 22243278
  3. Cloning and characterization of HB2, a candidate high density lipoprotein receptor. Sequence homology with members of the immunoglobulin superfamily of membrane proteins. Matsumoto A, et al. J Biol Chem, 1997 Jul 4. PMID 9201982
  4. Distribution and characteristics of a 90 kDa protein, KG-CAM, in the rat CNS. Peduzzi JD, et al. Brain Res, 1994 Mar 21. PMID 8004458
  5. Trisomy 10p due to t(5;10)(p15;p11) segregating in a large sibship. Back E, et al. Hum Genet, 1978 Feb 23. PMID 631856

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis.
    Title: MiRNA-192-5p-targeted activated leukocyte cell adhesion molecule improved inflammatory injury of neonatal necrotizing enterocolitis.
  2. the modulatory roles of ALCAM in the excitatory synaptic transmission and plasticity in the rat spinal dorsal horn
    Title: Activated leukocyte cell adhesion molecule is involved in excitatory synaptic transmission and plasticity in the rat spinal dorsal horn.
  3. ALCAM synergizes with nerve growth factor to induce neuronal differentiation, raising the possibility that it functions not only as an adhesion molecule but also in the modulation of growth factor signaling in the nervous system
    Title: Activated leukocyte cell adhesion molecule modulates neurotrophin signaling.
  4. The immunolocalisation of the stem cell-specific markers Notch-1, Delta, CD105 and CD166 was studied in rat femoral head articular cartilage. Corticosteroid (methylprednisolone) treatment was found to decrease the activity of these markers.
    Title: The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage.
  5. Localization of ALCAM specifically at cell-cell junctions in endothelial cells supported its role in transendothelial migration
    Title: Activated leukocyte cell adhesion molecule is a component of the endothelial junction involved in transendothelial monocyte migration.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in axon extension involved in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in motor neuron axon guidance IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within motor neuron axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection extension ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retinal ganglion cell axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of T cell receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CD166 antigen
Names
HB2
KG-CAM
SB-10 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031753.2 → NP_113941.1  CD166 antigen precursor

    See identical proteins and their annotated locations for NP_113941.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    O35112, O55172
    Conserved Domains (5) summary
    smart00406
    Location:38 → 113
    IGv; Immunoglobulin V-Type
    smart00410
    Location:255 → 329
    IG_like; Immunoglobulin like
    pfam08205
    Location:137 → 231
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:256 → 313
    Ig_3; Immunoglobulin domain
    cl11960
    Location:415 → 488
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    61804932..62005250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270772.1 → XP_063126842.1  CD166 antigen isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZQS5, A6IQS3
    Related
    ENSRNOP00000080494.1, ENSRNOT00000104562.2

  2. XM_063270773.1 → XP_063126843.1  CD166 antigen isoform X2

    UniProtKB/TrEMBL
    A0A8L2UHD3
    Related
    ENSRNOP00000002738.5, ENSRNOT00000002738.7

  3. XM_063270774.1 → XP_063126844.1  CD166 antigen isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35112.1 GenPept UniProtKB/Swiss-Prot:O35112

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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