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PARP8 poly(ADP-ribose) polymerase family member 8 [ Homo sapiens (human) ]

Gene ID: 79668, updated on 2-Nov-2024

Summary

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Official Symbol
PARP8provided by HGNC
Official Full Name
poly(ADP-ribose) polymerase family member 8provided by HGNC
Primary source
HGNC:HGNC:26124
See related
Ensembl:ENSG00000151883 AllianceGenome:HGNC:26124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTD16; pART16
Summary
Enables NAD+-protein ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in endoplasmic reticulum tubular network and nuclear envelope. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bone marrow (RPKM 11.4), thyroid (RPKM 9.6) and 24 other tissues See more
Orthologs
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Genomic context

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See PARP8 in Genome Data Viewer
Location:
5q11.1
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (50665931..50846519)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (51485094..51665708)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (49961765..50142353)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15999 Neighboring gene embigin Neighboring gene peptidylprolyl isomerase A like 4G pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16001 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:49963094-49964293 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:50218379-50218890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:50258938-50259475 Neighboring gene uncharacterized LOC124901181 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:50265501-50266022 Neighboring gene long intergenic non-protein coding RNA 2106

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. Fan Q, et al. PLoS Genet, 2012. PMID 22685421, Free PMC Article
  2. Genetics of callous-unemotional behavior in children. Viding E, et al. PLoS One, 2013. PMID 23874384, Free PMC Article
  3. The PARP superfamily. Amé JC, et al. Bioessays, 2004 Aug. PMID 15273990
  4. Family-wide analysis of poly(ADP-ribose) polymerase activity. Vyas S, et al. Nat Commun, 2014 Jul 21. PMID 25043379, Free PMC Article
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. Couzens AL, et al. Sci Signal, 2013 Nov 19. PMID 24255178

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants on chromosome 1q41 influence ocular axial length and high myopia.
EBI GWAS Catalog
Genetics of callous-unemotional behavior in children.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21308, MGC42864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein mono-ADP-ribosyltransferase PARP8
Names
ADP-ribosyltransferase diphtheria toxin-like 16
NP_001171526.1
NP_001171527.1
NP_001317957.1
NP_001413984.1
NP_078891.2
XP_011541933.1
XP_011541934.3
XP_011541935.3
XP_011541936.1
XP_011541945.1
XP_047273661.1
XP_047273662.1
XP_047273663.1
XP_047273664.1
XP_054209424.1
XP_054209425.1
XP_054209426.1
XP_054209427.1
XP_054209428.1
XP_054209429.1
XP_054209430.1
XP_054209431.1
XP_054209432.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178055.2 → NP_001171526.1  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    See identical proteins and their annotated locations for NP_001171526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC022441, AK314466, AL834477, DC429180
    Consensus CDS
    CCDS3954.1
    UniProtKB/Swiss-Prot
    Q3KRB7, Q6DHZ1, Q8N3A8, Q9H754
    UniProtKB/TrEMBL
    A8K004
    Related
    ENSP00000422217.2, ENST00000505697.6
    Conserved Domains (1) summary
    cd01341
    Location:694 → 818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  2. NM_001178056.2 → NP_001171527.1  protein mono-ADP-ribosyltransferase PARP8 isoform 2

    See identical proteins and their annotated locations for NP_001171527.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an exon in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC022441, AC112187, BC075801, DC417471, DC429180
    Consensus CDS
    CCDS54849.1
    UniProtKB/TrEMBL
    A8K004, B2RB27
    Related
    ENSP00000424814.2, ENST00000514067.6
    Conserved Domains (2) summary
    cd01341
    Location:652 → 776
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
    cl00283
    Location:482 → 563
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  3. NM_001331028.2 → NP_001317957.1  protein mono-ADP-ribosyltransferase PARP8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5'-terminal exon and an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008919, AC022441, AC112187
    Consensus CDS
    CCDS82996.1
    UniProtKB/TrEMBL
    A8K004, E9PFI7
    Related
    ENSP00000423946.1, ENST00000505554.5

  4. NM_001427055.1 → NP_001413984.1  protein mono-ADP-ribosyltransferase PARP8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008919, AC022441, AC112187

  5. NM_024615.4 → NP_078891.2  protein mono-ADP-ribosyltransferase PARP8 isoform 1

    See identical proteins and their annotated locations for NP_078891.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC022441, AC112187, AL834477, DC417471, DC429180
    Consensus CDS
    CCDS3954.1
    UniProtKB/Swiss-Prot
    Q3KRB7, Q6DHZ1, Q8N3A8, Q9H754
    UniProtKB/TrEMBL
    A8K004
    Related
    ENSP00000281631.4, ENST00000281631.10
    Conserved Domains (1) summary
    cd01341
    Location:694 → 818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    50665931..50846519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417705.1 → XP_047273661.1  protein mono-ADP-ribosyltransferase PARP8 isoform X5

  2. XM_011543631.4 → XP_011541933.1  protein mono-ADP-ribosyltransferase PARP8 isoform X2

    See identical proteins and their annotated locations for XP_011541933.1

    UniProtKB/Swiss-Prot
    Q3KRB7, Q6DHZ1, Q8N3A8, Q9H754
    UniProtKB/TrEMBL
    A8K004
    Conserved Domains (1) summary
    cd01341
    Location:694 → 818
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  3. XM_011543634.3 → XP_011541936.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

    See identical proteins and their annotated locations for XP_011541936.1

    UniProtKB/TrEMBL
    A8K004
    Conserved Domains (1) summary
    cd01341
    Location:634 → 758
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  4. XM_011543643.3 → XP_011541945.1  protein mono-ADP-ribosyltransferase PARP8 isoform X8

    See identical proteins and their annotated locations for XP_011541945.1

    UniProtKB/TrEMBL
    B4DQ81
    Conserved Domains (1) summary
    cd01341
    Location:500 → 624
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

  5. XM_011543632.4 → XP_011541934.3  protein mono-ADP-ribosyltransferase PARP8 isoform X3

  6. XM_011543633.4 → XP_011541935.3  protein mono-ADP-ribosyltransferase PARP8 isoform X4

  7. XM_047417707.1 → XP_047273663.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

  8. XM_047417708.1 → XP_047273664.1  protein mono-ADP-ribosyltransferase PARP8 isoform X7

  9. XM_047417706.1 → XP_047273662.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    51485094..51665708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353452.1 → XP_054209427.1  protein mono-ADP-ribosyltransferase PARP8 isoform X5

  2. XM_054353449.1 → XP_054209424.1  protein mono-ADP-ribosyltransferase PARP8 isoform X2

    UniProtKB/Swiss-Prot
    Q3KRB7, Q6DHZ1, Q8N3A8, Q9H754

  3. XM_054353450.1 → XP_054209425.1  protein mono-ADP-ribosyltransferase PARP8 isoform X3

  4. XM_054353451.1 → XP_054209426.1  protein mono-ADP-ribosyltransferase PARP8 isoform X4

  5. XM_054353453.1 → XP_054209428.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

  6. XM_054353457.1 → XP_054209432.1  protein mono-ADP-ribosyltransferase PARP8 isoform X8

  7. XM_054353455.1 → XP_054209430.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

  8. XM_054353456.1 → XP_054209431.1  protein mono-ADP-ribosyltransferase PARP8 isoform X7

  9. XM_054353454.1 → XP_054209429.1  protein mono-ADP-ribosyltransferase PARP8 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3A8.1 GenPept UniProtKB/Swiss-Prot:Q8N3A8

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