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ZNF322 zinc finger protein 322 [ Homo sapiens (human) ]

Gene ID: 79692, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF322provided by HGNC
Official Full Name
zinc finger protein 322provided by HGNC
Primary source
HGNC:HGNC:23640
See related
Ensembl:ENSG00000181315 MIM:610847; AllianceGenome:HGNC:23640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCG12; ZNF388; ZNF489; ZNF322A
Summary
ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in endometrium (RPKM 9.4), thyroid (RPKM 9.3) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
6p22.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26634383..26659746, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (26502803..26528154, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26634611..26659974, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374989 Neighboring gene vomeronasal 1 receptor 14 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659404-26659904 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:26659905-26660405 Neighboring gene uncharacterized LOC102724851 Neighboring gene tRNA-Ala (anticodon AGC) 14-1 Neighboring gene tRNA-Ala (anticodon AGC) 12-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression. Liao SY, et al. Oncogene, 2019 Oct. PMID 31399647
  2. ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways. Li Y, et al. Biochem Biophys Res Commun, 2004 Dec 24. PMID 15555580
  3. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. Cheung CHY, et al. J Biomed Sci, 2020 Jun 23. PMID 32576196, Free PMC Article
  4. Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression. Jen J, et al. Cell Death Differ, 2019 Jul. PMID 30258097, Free PMC Article
  5. miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322. Hu X, et al. Cell Biol Int, 2018 Aug. PMID 28880489

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer.
    Title: Downregulation of microRNA-326 enhances ZNF322A expression, transcriptional activity and tumorigenic effects in lung cancer.
  2. Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.
    Title: Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.
  3. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer.
    Title: ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer.
  4. The ZNF322A-centered transcriptome promotes lung tumorigenesis and ZNF322A acts as a transcription suppressor of c-Myc to maintain lung cancer stem cell-like properties by shifting metabolism towards oxidative phosphorylation.
    Title: Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression.
  5. results reveal a new mechanism of AKT signaling in promoting ZNF322A protein stability and transcriptional activity in lung cancer cell, xenograft, and clinical models
    Title: AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression.
  6. Silencing ZNF322 recapitulated the cellular and molecular effects seen upon miR-4317 overexpression.
    Title: miRNA-4317 suppresses human gastric cancer cell proliferation by targeting ZNF322.
  7. Our results reveal a new mechanism of ZNF322A oncoprotein destruction regulated by the CK1delta/GSK3beta/FBXW7a axis. Deregulation of this signaling axis results in ZNF322A overexpression and promotes cancer progression
    Title: CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression.
  8. ZNF322A overexpression transcriptionally dysregulates genes involved in cell growth and motility therefore contributes to lung tumorigenesis and poor prognosis
    Title: Oncoprotein ZNF322A transcriptionally deregulates alpha-adducin, cyclin D1 and p53 to promote tumor growth and metastasis in lung cancer.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. These results suggest that ZNF322 is a member of the zinc-finger transcription factor family and may act as a positive regulator in gene transcription mediated by the MAPK signaling pathways.
    Title: ZNF322, a novel human C2H2 Kruppel-like zinc-finger protein, regulates transcriptional activation in MAPK signaling pathways.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23393

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger protein 322
Names
HLA complex group 12
zinc finger protein 322A
zinc finger protein 388
zinc finger protein 489

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242797.2 → NP_001229726.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001229726.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL513548, DA481584
    Consensus CDS
    CCDS4617.1
    UniProtKB/Swiss-Prot
    A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
    Related
    ENSP00000482607.1, ENST00000622479.4
    Conserved Domains (3) summary
    COG5048
    Location:69 → 219
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001242798.2 → NP_001229727.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001229727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL513548, DA437716
    Consensus CDS
    CCDS4617.1
    UniProtKB/Swiss-Prot
    A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
    Related
    ENSP00000483223.1, ENST00000607204.5
    Conserved Domains (3) summary
    COG5048
    Location:69 → 219
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001242799.2 → NP_001229728.1  zinc finger protein 322

    See identical proteins and their annotated locations for NP_001229728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL513548, DB454351
    Consensus CDS
    CCDS4617.1
    UniProtKB/Swiss-Prot
    A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
    Related
    ENSP00000478899.1, ENST00000456172.5
    Conserved Domains (3) summary
    COG5048
    Location:69 → 219
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_024639.5 → NP_078915.2  zinc finger protein 322

    See identical proteins and their annotated locations for NP_078915.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK290038, AL513548, BX474628
    Consensus CDS
    CCDS4617.1
    UniProtKB/Swiss-Prot
    A8K1X3, Q0VDH6, Q6B0G2, Q6U7Q0, Q86W72, Q9H5I9
    Related
    ENSP00000418897.1, ENST00000415922.7
    Conserved Domains (3) summary
    COG5048
    Location:69 → 219
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:207 → 291
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:129 → 149
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    26634383..26659746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791780.1 Reference GRCh38.p14 PATCHES

    Range
    180572..205907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008485816.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    26502803..26528154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487434.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6U7Q0.2 GenPept UniProtKB/Swiss-Prot:Q6U7Q0

Gene LinkOut

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