RIOX1 ribosomal oxygenase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RIOX1provided by HGNC
Official Full Name: ribosomal oxygenase 1provided by HGNC
Primary source: HGNC:HGNC:20968
See related: Ensembl:ENSG00000170468 MIM:611919; AllianceGenome:HGNC:20968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
Summary: Enables peptidyl-histidine dioxygenase activity and protein demethylase activity. Predicted to be involved in negative regulation of DNA-templated transcription; negative regulation of osteoblast differentiation; and protein demethylation. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 14q24.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (73490933..73493394)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (67698891..67701354)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (73957638..73960098)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The JmjC-domain protein NO66/RIOX-1 affects the balance between proliferation and maturation in acute myeloid leukemia.
Title: The JmjC-domain protein NO66/RIOX-1 affects the balance between proliferation and maturation in acute myeloid leukemia.
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Title: NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Mechanisms Regulating Muscle Protein Synthesis in CKD.
Title: Mechanisms Regulating Muscle Protein Synthesis in CKD.
The role of NO66 as a key oncogenic driver in Prostate cancer, causing osteolytic lesions through upstream epigenetic regulation of key genes for survival, invasion and metastasis, and pro-osteoclastic factors.
Title: Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer.
High NO66 expression is associated with Glioma.
Title: The Histone Demethylase NO66 Induces Glioma Cell Proliferation.
our findings clearly indicated that epigenetic regulation by NO66 plays an important role in cancer metastatic processes in CRC.
Title: Clinical Significance of Histone Demethylase NO66 in Invasive Colorectal Cancer.
Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.
Title: Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication.
confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8
Title: Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8.
hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx-dependent gene activation.
Title: Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression.
NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit
Title: Purification, crystallization and preliminary crystallographic analysis of histone lysine demethylase NO66 from Homo sapiens.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-22498 (e-PCR)
- UniSTS:28748

G38173 (e-PCR)
- UniSTS:642

STS-Z40969 (e-PCR)
- UniSTS:64901

SHGC-56451 (e-PCR)
- UniSTS:32396

ksks225 (e-PCR)
- UniSTS:514259

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-oxoglutarate-dependent dioxygenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K36 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36me/H3K36me2 demethylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 demethylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4me/H3K4me2/H3K4me3 demethylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidyl-histidine dioxygenase activity	EXP Inferred from Experiment more info	PubMed
enables peptidyl-histidine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein demethylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ribosomal oxygenase 1

Names: 60S ribosomal protein L8 histidine hydroxylase; MYC-associated protein with JmjC domain; bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; nucleolar protein 66; ribosomal oxygenase NO66; up-regulated in lung cancer 2

NP_078920.2

EC 1.14.11.27

EC 1.14.11.79

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.