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MORC4 MORC family CW-type zinc finger 4 [ Homo sapiens (human) ]

Gene ID: 79710, updated on 3-Nov-2024

Summary

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Official Symbol
MORC4provided by HGNC
Official Full Name
MORC family CW-type zinc finger 4provided by HGNC
Primary source
HGNC:HGNC:23485
See related
Ensembl:ENSG00000133131 MIM:300970; AllianceGenome:HGNC:23485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW4; ZCWCC2; dJ75H8.2
Summary
In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Expression
Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues See more
Orthologs
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Genomic context

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See MORC4 in Genome Data Viewer
Location:
Xq22.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (106940738..107000212, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105377254..105436736, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106183968..106243442, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29830 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106137885-106138409 Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106176295-106176796 Neighboring gene Sharpr-MPRA regulatory region 10711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:106209370-106209870 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20926 Neighboring gene NANOG hESC enhancer GRCh37_chrX:106261730-106262231 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene RNA binding motif protein 41 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29831 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29832

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MORC4, a novel member of the MORC family, is highly expressed in a subset of diffuse large B-cell lymphomas. Liggins AP, et al. Br J Haematol, 2007 Aug. PMID 17608765
  2. Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation. Campa D, et al. Int J Cancer, 2018 Jan 15. PMID 28913878
  3. Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis. Giri AK, et al. PLoS One, 2016. PMID 26820620, Free PMC Article
  4. MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p. Yang Z, et al. J Cell Biochem, 2019 Mar. PMID 30320920
  5. Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease. Söderman J, et al. World J Gastroenterol, 2013 Aug 14. PMID 23946598, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.
    Title: MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo.
  2. These results identified MORC4 as differentially expressed in breast cancer cells and tissues and its downregulation by miR-193b-3p, as well as its roles in regulating the growth of breast cancer cells via regulation of apoptosis.
    Title: MORC4 is a novel breast cancer oncogene regulated by miR-193b-3p.
  3. SNP in the MORC4-rs 12837024 is associated with Chronic pancreatitis.
    Title: Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
  4. Genetic variation in MORC4, CD14, and TLR4 may affect the outcome of allogeneic stem cell transplantation.
    Title: Single Nucleotide Polymorphisms in MORC4, CD14, and TLR4 Are Related to Outcome of Allogeneic Stem Cell Transplantation.
  5. Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients.
    Title: Common Variants in CLDN2 and MORC4 Genes Confer Disease Susceptibility in Patients with Chronic Pancreatitis.
  6. Single nucleotide polymorphism is a risk factor developing chronic alcoholic pancreatitis.
    Title: Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study.
  7. Findings suggest that a variant of the CLDN2-MORC4 region predisposes to Crohn's disease in a Swedish population.
    Title: Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MORC family CW-type zinc finger protein 4
Names
zinc finger CW-type coiled-coil domain protein 2
zinc finger CW-type domain protein 4
zinc finger, CW type with coiled-coil domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016392.1 RefSeqGene

    Range
    5033..64507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001085354.3 → NP_001078823.1  MORC family CW-type zinc finger protein 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the CDS compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK300305, BQ101064, CA448781, CB989767, EF125209
    Consensus CDS
    CCDS48146.1
    UniProtKB/TrEMBL
    B4DTP6
    Related
    ENSP00000255495.7, ENST00000255495.7
    Conserved Domains (3) summary
    pfam06625
    Location:762 → 814
    DUF1151; Protein of unknown function (DUF1151)
    pfam07496
    Location:425 → 469
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50 → 170
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

  2. NM_024657.5 → NP_078933.3  MORC family CW-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_078933.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK300305, BQ101064, CA448781, CB989767, EF125209
    Consensus CDS
    CCDS14525.2
    UniProtKB/Swiss-Prot
    A1YR23, A1YR24, H7BXF1, Q5JUK7, Q8TE76, Q96MZ2, Q9HAI7
    UniProtKB/TrEMBL
    B4DTP6
    Related
    ENSP00000347821.4, ENST00000355610.9
    Conserved Domains (3) summary
    pfam06625
    Location:762 → 814
    DUF1151; Protein of unknown function (DUF1151)
    pfam07496
    Location:425 → 469
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50 → 170
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    106940738..107000212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    105377254..105436736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TE76.2 GenPept UniProtKB/Swiss-Prot:Q8TE76

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