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E2F8 E2F transcription factor 8 [ Homo sapiens (human) ]

Gene ID: 79733, updated on 2-Nov-2024

Summary

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Official Symbol
E2F8provided by HGNC
Official Full Name
E2F transcription factor 8provided by HGNC
Primary source
HGNC:HGNC:24727
See related
Ensembl:ENSG00000129173 MIM:612047; AllianceGenome:HGNC:24727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E2F-8
Summary
This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Expression
Broad expression in bone marrow (RPKM 4.6), lymph node (RPKM 3.5) and 14 other tissues See more
Orthologs
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Genomic context

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See E2F8 in Genome Data Viewer
Location:
11p15.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (19224063..19241655, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (19344150..19361742, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (19245610..19263202, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3197 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3195 Neighboring gene VISTA enhancer hs2144 Neighboring gene zinc finger DHHC-type palmitoyltransferase 13 Neighboring gene VISTA enhancer hs2145 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:19253866-19255065 Neighboring gene CSRP3 and E2F8 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:19263697-19264268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:19264269-19264838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4515 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:19290948-19291137 Neighboring gene Sharpr-MPRA regulatory region 11719 Neighboring gene cysteine and glycine rich protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4517 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3199 Neighboring gene proliferating cell nuclear antigen pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:19416525-19417056 Neighboring gene RNA, 5S ribosomal pseudogene 335 Neighboring gene neuron navigator 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer. Eoh KJ, et al. Int J Mol Sci, 2020 Aug 13. PMID 32823614, Free PMC Article
  2. Knockdown of E2F8 Suppresses Cell Proliferation in Colon Cancer Cells by Modulating the NF-κB Pathway. Yan PY, et al. Ann Clin Lab Sci, 2019 Sep. PMID 31471336
  3. E2F8 regulates the proliferation and invasion through epithelial-mesenchymal transition in cervical cancer. Kim LK, et al. Int J Biol Sci, 2020. PMID 31929759, Free PMC Article
  4. Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report. Lü Y, et al. Biosci Rep, 2020 Feb 28. PMID 31990034, Free PMC Article
  5. Cell cycle oscillators underlying orderly proteolysis of E2F8. Wasserman D, et al. Mol Biol Cell, 2020 Apr 1. PMID 31995441, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
    Title: TJP1 suppresses trophoblast cell invasion by expressing E2F8 in the human placenta.
  2. ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage.
    Title: ENO1 promotes trophoblast invasion regulated by E2F8 in recurrent miscarriage.
  3. E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.
    Title: E2F8 exerts cancer-promoting effects by transcriptionally activating RRM2 and E2F8 knockdown synergizes with WEE1 inhibition in suppressing lung adenocarcinoma.
  4. Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK-dependent manner.
    Title: Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner.
  5. E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/beta-Catenin pathway in ovarian cancer.
    Title: E2F8 knockdown suppresses cell proliferation and induces cell cycle arrest via Wnt/β-Catenin pathway in ovarian cancer.
  6. Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
    Title: Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation.
  7. Cell cycle oscillators underlying orderly proteolysis of E2F8.
    Title: Cell cycle oscillators underlying orderly proteolysis of E2F8.
  8. E2F transcription factor 8 promotes proliferation and radioresistance in glioblastoma.
    Title: E2F transcription factor 8 promotes proliferation and radioresistance in glioblastoma.
  9. Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report.
    Title: Carcinogenesis effects of E2F transcription factor 8 (E2F8) in hepatocellular carcinoma outcomes: an integrated bioinformatic report.
  10. E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer.
    Title: E2F8 Induces Cell Proliferation and Invasion through the Epithelial-Mesenchymal Transition and Notch Signaling Pathways in Ovarian Cancer.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables DNA-binding transcription repressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell cycle comprising mitosis without cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chorionic trophoblast cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in placenta development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA endoreduplication ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trophoblast giant cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
transcription factor E2F8
Names
E2F family member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256371.2 → NP_001243300.1  transcription factor E2F8

    See identical proteins and their annotated locations for NP_001243300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009652, BM972658, DA758300
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6, A8K9H3, Q2VPJ3, Q3C1U6, Q5BKY4, Q8N340, Q9H5M0
    Related
    ENSP00000481103.1, ENST00000620009.4
    Conserved Domains (2) summary
    pfam02319
    Location:114 → 182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464 → 700
    Atrophin-1; Atrophin-1 family

  2. NM_001256372.1 → NP_001243301.1  transcription factor E2F8

    See identical proteins and their annotated locations for NP_001243301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC009652, AK292688, BM972658, BX504614
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6, A8K9H3, Q2VPJ3, Q3C1U6, Q5BKY4, Q8N340, Q9H5M0
    Related
    ENSP00000434199.1, ENST00000527884.5
    Conserved Domains (2) summary
    pfam02319
    Location:114 → 182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464 → 700
    Atrophin-1; Atrophin-1 family

  3. NM_024680.4 → NP_078956.2  transcription factor E2F8

    See identical proteins and their annotated locations for NP_078956.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK026964, AK055206, BC028244, BM972658, BU164108, BX504614, CB959621
    Consensus CDS
    CCDS7849.1
    UniProtKB/Swiss-Prot
    A0AVK6, A8K9H3, Q2VPJ3, Q3C1U6, Q5BKY4, Q8N340, Q9H5M0
    Related
    ENSP00000250024.4, ENST00000250024.9
    Conserved Domains (2) summary
    pfam02319
    Location:114 → 182
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    cl26464
    Location:464 → 700
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    19224063..19241655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427596.1 → XP_047283552.1  transcription factor E2F8 isoform X1

  2. XM_047427597.1 → XP_047283553.1  transcription factor E2F8 isoform X1

  3. XM_011520367.2 → XP_011518669.1  transcription factor E2F8 isoform X1

    Conserved Domains (1) summary
    pfam02319
    Location:158 → 242
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain

  4. XM_047427598.1 → XP_047283554.1  transcription factor E2F8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    19344150..19361742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369957.1 → XP_054225932.1  transcription factor E2F8 isoform X1

  2. XM_054369958.1 → XP_054225933.1  transcription factor E2F8 isoform X1

  3. XM_054369956.1 → XP_054225931.1  transcription factor E2F8 isoform X1

  4. XM_054369959.1 → XP_054225934.1  transcription factor E2F8 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0AVK6.1 GenPept UniProtKB/Swiss-Prot:A0AVK6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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