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DNAI4 dynein axonemal intermediate chain 4 [ Homo sapiens (human) ]

Gene ID: 79819, updated on 3-Nov-2024

Summary

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Official Symbol
DNAI4provided by HGNC
Official Full Name
dynein axonemal intermediate chain 4provided by HGNC
Primary source
HGNC:HGNC:26252
See related
Ensembl:ENSG00000152763 MIM:619156; AllianceGenome:HGNC:26252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC4; WDR78
Summary
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in axonemal dynein complex assembly and cilium movement. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in axoneme; dynein axonemal particle; and motile cilium. Predicted to be part of axonemal dynein complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 11.4), thyroid (RPKM 2.6) and 9 other tissues See more
Orthologs
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Genomic context

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See DNAI4 in Genome Data Viewer
Location:
1p31.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (66812885..66924856, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (66690412..66802384, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67278568..67390539, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type family member 5 Neighboring gene insulin like 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 973 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 974 Neighboring gene MIER1 transcriptional regulator Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 975 Neighboring gene MPRA-validated peak274 silencer Neighboring gene solute carrier family 35 member D1 Neighboring gene MPRA-validated peak275 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:67486227-67487025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 978 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:67562817-67563435 Neighboring gene small nucleolar RNA SNORA31 Neighboring gene chromosome 1 open reading frame 141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A unified taxonomy for ciliary dyneins. Hom EF, et al. Cytoskeleton (Hoboken), 2011 Oct. PMID 21953912, Free PMC Article
  2. Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein. Meng X, et al. J Biol Chem, 2012 Feb 10. PMID 22199357, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. DSBSO-Based XL-MS Analysis of Breast Cancer PDX Tissues to Delineate Protein Interaction Network in Clinical Samples. Jiao F, et al. J Proteome Res, 2024 Aug 2. PMID 38334954, Free PMC Article
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23129

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axonemal dynein complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of axonemal dynein complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein axonemal intermediate chain 4
Names
WD repeat domain 78
WD repeat-containing protein 78
dynein intermediate chain 4, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024763.5 → NP_079039.4  dynein axonemal intermediate chain 4 isoform 1

    See identical proteins and their annotated locations for NP_079039.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL133617, BC126381, DA916550
    Consensus CDS
    CCDS635.1
    UniProtKB/Swiss-Prot
    A8K9W5, B5MDT3, H7BY80, Q5VTH9, Q5VTI0, Q8N5G5, Q9H5R9, Q9UF44
    UniProtKB/TrEMBL
    A0AVI9
    Related
    ENSP00000360065.3, ENST00000371026.8
    Conserved Domains (3) summary
    COG2319
    Location:485 → 845
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:707 → 744
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:493 → 775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_207014.3 → NP_996897.2  dynein axonemal intermediate chain 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC032406, DA916550
    Consensus CDS
    CCDS44157.1
    UniProtKB/Swiss-Prot
    Q5VTH9
    Related
    ENSP00000360062.3, ENST00000371023.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    66812885..66924856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002354.2 → XP_016857843.1  dynein axonemal intermediate chain 4 isoform X8

    UniProtKB/TrEMBL
    A0AVI9

  2. XM_047430752.1 → XP_047286708.1  dynein axonemal intermediate chain 4 isoform X6

  3. XM_017002353.2 → XP_016857842.1  dynein axonemal intermediate chain 4 isoform X7

    UniProtKB/TrEMBL
    A0AVI9

  4. XM_005271212.4 → XP_005271269.1  dynein axonemal intermediate chain 4 isoform X4

    UniProtKB/TrEMBL
    A0AVI9
    Conserved Domains (3) summary
    COG2319
    Location:420 → 780
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:642 → 679
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:428 → 710
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_047430731.1 → XP_047286687.1  dynein axonemal intermediate chain 4 isoform X3

  6. XM_011542161.3 → XP_011540463.1  dynein axonemal intermediate chain 4 isoform X1

    UniProtKB/TrEMBL
    A0AVI9
    Conserved Domains (3) summary
    COG2319
    Location:482 → 816
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:678 → 715
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:509 → 746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_011542162.3 → XP_011540464.1  dynein axonemal intermediate chain 4 isoform X2

    UniProtKB/TrEMBL
    A0AVI9
    Conserved Domains (3) summary
    COG2319
    Location:488 → 812
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:539 → 583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:538 → 800
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  8. XM_047430749.1 → XP_047286705.1  dynein axonemal intermediate chain 4 isoform X5

  9. XM_017002355.1 → XP_016857844.1  dynein axonemal intermediate chain 4 isoform X9

    UniProtKB/TrEMBL
    H0YDI6
    Related
    ENSP00000433682.1, ENST00000464352.6

  10. XM_024449821.2 → XP_024305589.1  dynein axonemal intermediate chain 4 isoform X10

    UniProtKB/TrEMBL
    H0YDI6
    Conserved Domains (2) summary
    COG2319
    Location:196 → 536
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:418 → 455
    7WD40; WD40 repeat [structural motif]

  11. XM_017002357.2 → XP_016857846.1  dynein axonemal intermediate chain 4 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    66690412..66802384 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338779.1 → XP_054194754.1  dynein axonemal intermediate chain 4 isoform X8

  2. XM_054338777.1 → XP_054194752.1  dynein axonemal intermediate chain 4 isoform X6

  3. XM_054338778.1 → XP_054194753.1  dynein axonemal intermediate chain 4 isoform X7

  4. XM_054338775.1 → XP_054194750.1  dynein axonemal intermediate chain 4 isoform X4

  5. XM_054338774.1 → XP_054194749.1  dynein axonemal intermediate chain 4 isoform X3

  6. XM_054338772.1 → XP_054194747.1  dynein axonemal intermediate chain 4 isoform X1

  7. XM_054338773.1 → XP_054194748.1  dynein axonemal intermediate chain 4 isoform X2

  8. XM_054338776.1 → XP_054194751.1  dynein axonemal intermediate chain 4 isoform X5

  9. XM_054338780.1 → XP_054194755.1  dynein axonemal intermediate chain 4 isoform X9

  10. XM_054338781.1 → XP_054194756.1  dynein axonemal intermediate chain 4 isoform X10

  11. XM_054338782.1 → XP_054194757.1  dynein axonemal intermediate chain 4 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5VTH9.1 GenPept UniProtKB/Swiss-Prot:Q5VTH9

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