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LINC00115 long intergenic non-protein coding RNA 115 [ Homo sapiens (human) ]

Gene ID: 79854, updated on 17-Sep-2024

Summary

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Official Symbol
LINC00115provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 115provided by HGNC
Primary source
HGNC:HGNC:26211
See related
AllianceGenome:HGNC:26211
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRNA00115
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Genomic context

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See LINC00115 in Genome Data Viewer
Location:
1p36.33
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (826206..827522, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (255178..256494, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (761586..762902, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1409 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:726662-727228 Neighboring gene uncharacterized LOC124903817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2 Neighboring gene family with sequence similarity 87 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1 Neighboring gene long intergenic non-protein coding RNA 1128 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:772694-772873 Neighboring gene uncharacterized LOC107984850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:802261-802760 Neighboring gene family with sequence similarity 41 member C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies. Xu Z, et al. Gene, 2024 Mar 1. PMID 38070791
  2. Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2). Ji F, et al. Bioengineered, 2022 Mar. PMID 35184643, Free PMC Article
  3. Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/β-catenin axis. Peng N, et al. J Cell Mol Med, 2021 Nov. PMID 34697900, Free PMC Article
  4. Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7. Yuan C, et al. FEBS Open Bio, 2020 Jul. PMID 32175684, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies.
    Title: Long intergenic non-protein coding RNA 115 (Linc00115): A notable oncogene in human malignancies.
  2. Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2).
    Title: Long intergenic non-protein coding RNA 115 (LINC00115) aggravates retinoblastoma progression by targeting microRNA miR-489-3p that downregulates 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2).
  3. Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/beta-catenin axis.
    Title: Down-regulated LINC00115 inhibits prostate cancer cell proliferation and invasion via targeting miR-212-5p/FZD5/Wnt/β-catenin axis.
  4. Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7.
    Title: Long noncoding RNA LINC00115 promotes breast cancer metastasis by inhibiting miR-7.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Clone Names

  • FLJ22639

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024321.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669831

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    826206..827522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    255178..256494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024796.1: Suppressed sequence

    Description
    NM_024796.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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