U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF672 zinc finger protein 672 [ Homo sapiens (human) ]

Gene ID: 79894, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF672provided by HGNC
Official Full Name
zinc finger protein 672provided by HGNC
Primary source
HGNC:HGNC:26179
See related
Ensembl:ENSG00000171161 AllianceGenome:HGNC:26179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in spleen (RPKM 7.7), prostate (RPKM 7.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF672 in Genome Data Viewer
Location:
1q44
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248838224..248849517)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (248276707..248288000)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (249132423..249143716)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2049 Neighboring gene SH3 binding domain protein 5 like Neighboring gene Sharpr-MPRA regulatory region 9626 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:249114909-249116108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:249119908-249120459 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249120460-249121010 Neighboring gene microRNA 3124 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132357-249132858 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:249132859-249133358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2881 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2882 Neighboring gene zinc finger protein 692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2885 Neighboring gene ZNF692 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2887

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ22301

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 672

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024836.3 → NP_079112.1  zinc finger protein 672

    See identical proteins and their annotated locations for NP_079112.1

    Status: VALIDATED

    Source sequence(s)
    AI127478, BC007385, BC029310, HY030669
    Consensus CDS
    CCDS1638.1
    UniProtKB/Swiss-Prot
    Q499Z4, Q96H65, Q96IM3, Q9H6G5
    Related
    ENSP00000421915.1, ENST00000306562.8
    Conserved Domains (3) summary
    COG5048
    Location:12 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:325 → 350
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248838224..248849517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430823.1 → XP_047286779.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q499Z4, Q96H65, Q96IM3, Q9H6G5

  2. XM_005270336.3 → XP_005270393.1  zinc finger protein 672 isoform X1

    See identical proteins and their annotated locations for XP_005270393.1

    UniProtKB/Swiss-Prot
    Q499Z4, Q96H65, Q96IM3, Q9H6G5
    Conserved Domains (3) summary
    COG5048
    Location:12 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:285 → 305
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:325 → 350
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    248276707..248288000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338802.1 → XP_054194777.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q499Z4, Q96H65, Q96IM3, Q9H6G5

  2. XM_054338803.1 → XP_054194778.1  zinc finger protein 672 isoform X1

    UniProtKB/Swiss-Prot
    Q499Z4, Q96H65, Q96IM3, Q9H6G5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499Z4.2 GenPept UniProtKB/Swiss-Prot:Q499Z4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools