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WLS Wnt ligand secretion mediator [ Homo sapiens (human) ]

Gene ID: 79971, updated on 2-Nov-2024

Summary

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Official Symbol
WLSprovided by HGNC
Official Full Name
Wnt ligand secretion mediatorprovided by HGNC
Primary source
HGNC:HGNC:30238
See related
Ensembl:ENSG00000116729 MIM:611514; AllianceGenome:HGNC:30238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVI; MRP; ZKS; GPR177; mig-14; C1orf139
Summary
Enables Wnt-protein binding activity and identical protein binding activity. Involved in positive regulation of cell communication and protein transport. Located in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum membrane. Implicated in Zaki syndrome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney (RPKM 32.7), gall bladder (RPKM 31.7) and 24 other tissues See more
Orthologs
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Genomic context

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See WLS in Genome Data Viewer
Location:
1p31.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (68098459..68232546, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (67975934..68110470, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (68564142..68698229, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GNG12, DIRAS3 and WLS antisense RNA 1 Neighboring gene sirtuin 5 pseudogene Neighboring gene ARL5A pseudogene 3 Neighboring gene DIRAS family GTPase 3 Neighboring gene Sharpr-MPRA regulatory region 5584 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:68613408-68614607 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:68627528-68628104 Neighboring gene CTBP2 pseudogene 8 Neighboring gene NANOG hESC enhancer GRCh37_chr1:68665327-68665828 Neighboring gene microRNA 1262 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:68742024-68742651 Neighboring gene NANOG hESC enhancer GRCh37_chr1:68743733-68744317 Neighboring gene ribosomal protein S7 pseudogene 4 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis. Kantaputra P, et al. Eur J Orthod, 2023 May 31. PMID 36374649
  2. Genetic association study identified a 20 kb regulatory element in WLS associated with osteoporosis and bone mineral density in Han Chinese. Zhang D, et al. Sci Rep, 2017 Oct 20. PMID 29057911, Free PMC Article
  3. WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis. Yang PT, et al. EMBO Mol Med, 2012 Dec. PMID 23129487, Free PMC Article
  4. The Wnt secretion protein Evi/Gpr177 promotes glioma tumourigenesis. Augustin I, et al. EMBO Mol Med, 2012 Jan. PMID 22147553, Free PMC Article
  5. Wntless (GPR177) expression correlates with poor prognosis in B-cell precursor acute lymphoblastic leukemia via Wnt signaling. Chiou SS, et al. Carcinogenesis, 2014 Oct. PMID 25115440

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expanding the phenotypic spectrum and clinical severity associated with WLS gene.
    Title: Expanding the phenotypic spectrum and clinical severity associated with WLS gene.
  2. Compound heterozygous variants in WLS gene causes Zaki syndrome.
    Title: Compound heterozygous variants in WLS gene causes Zaki syndrome.
  3. Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.
    Title: Mutations in the WLS are associated with dental anomalies, torus palatinus, and torus mandibularis.
  4. The role of Evi/Wntless in exporting Wnt proteins.
    Title: The role of Evi/Wntless in exporting Wnt proteins.
  5. GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
    Title: GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
  6. Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses.
    Title: Responses of Porcupine and Wntless proteins to oxidative, hypoxic and endoplasmic reticulum stresses.
  7. Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
    Title: Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.
  8. Cryo-EM structure of human Wntless in complex with Wnt3a.
    Title: Cryo-EM structure of human Wntless in complex with Wnt3a.
  9. SNHG17 upregulates WLS expression to accelerate lung adenocarcinoma progression by sponging miR-485-5p.
    Title: SNHG17 upregulates WLS expression to accelerate lung adenocarcinoma progression by sponging miR-485-5p.
  10. MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells.
    Title: MicroRNA-31 Regulates Expression of Wntless in Both Drosophila melanogaster and Human Oral Cancer Cells.
Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Zaki syndrome
MedGen: C5562037 OMIM: 619648 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
EBI GWAS Catalog
Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
EBI GWAS Catalog
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23091, MGC14878, MGC131760, DKFZp686I0788

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables Wnt-protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cementum mineralization IEA
Inferred from Electronic Annotation
more info
  
involved_in exocrine pancreas development IEA
Inferred from Electronic Annotation
more info
  
involved_in hindbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
  
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of Wnt protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome TAS
Traceable Author Statement
more info
  
is_active_in organelle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein wntless homolog
Names
G protein-coupled receptor 177
integral membrane protein GPR177
protein evenness interrupted homolog
putative NF-kappa-B-activating protein 373
putative NFkB activating protein 373
wntless Wnt ligand secretion mediator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002292.4 → NP_001002292.3  protein wntless homolog isoform 2

    See identical proteins and their annotated locations for NP_001002292.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, and differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL513284, BX538320, CA438784, DA753300
    Consensus CDS
    CCDS30750.1
    UniProtKB/TrEMBL
    Q96IV8
    Related
    ENSP00000346829.2, ENST00000354777.6
    Conserved Domains (1) summary
    pfam06664
    Location:176 → 494
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  2. NM_001193334.1 → NP_001180263.1  protein wntless homolog isoform 3

    See identical proteins and their annotated locations for NP_001180263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AL513284, AW137622, BX648748, DA753300, DB478499
    Consensus CDS
    CCDS53331.1
    UniProtKB/TrEMBL
    Q96IV8
    Related
    ENSP00000360015.3, ENST00000370976.7
    Conserved Domains (1) summary
    pfam06664
    Location:87 → 405
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

  3. NM_024911.7 → NP_079187.3  protein wntless homolog isoform 1

    See identical proteins and their annotated locations for NP_079187.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AW137622, DQ323735
    Consensus CDS
    CCDS642.1
    UniProtKB/Swiss-Prot
    B2RNT2, Q5JRS7, Q5T9L3, Q7Z2Z9, Q8NC43
    UniProtKB/TrEMBL
    Q96IV8
    Related
    ENSP00000262348.4, ENST00000262348.9
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    68098459..68232546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542191.3 → XP_011540493.1  protein wntless homolog isoform X1

    See identical proteins and their annotated locations for XP_011540493.1

    UniProtKB/TrEMBL
    Q96IV8
    Conserved Domains (1) summary
    pfam06664
    Location:178 → 496
    MIG-14_Wnt-bd; Wnt-binding factor required for Wnt secretion

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    67975934..68110470 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338846.1 → XP_054194821.1  protein wntless homolog isoform X1

  2. XM_054338847.1 → XP_054194822.1  protein wntless homolog isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5T9L3.2 GenPept UniProtKB/Swiss-Prot:Q5T9L3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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