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TMEM156 transmembrane protein 156 [ Homo sapiens (human) ]

Gene ID: 80008, updated on 2-Nov-2024

Summary

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Official Symbol
TMEM156provided by HGNC
Official Full Name
transmembrane protein 156provided by HGNC
Primary source
HGNC:HGNC:26260
See related
Ensembl:ENSG00000121895 AllianceGenome:HGNC:26260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in lymph node (RPKM 3.2), spleen (RPKM 1.6) and 9 other tissues See more
Orthologs
mouse all
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Genomic context

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See TMEM156 in Genome Data Viewer
Location:
4p14
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (38966744..39032409, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (38936798..39002606, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38968365..39034029, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900695 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21450 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21452 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80034 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80044 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:38858887-38860086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:38869978-38870561 Neighboring gene toll like receptor 6 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80048 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80049 Neighboring gene family with sequence similarity 114 member A1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_80051 Neighboring gene microRNA 574 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:38989899-38990398 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:39038547-39039076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15366 Neighboring gene uncharacterized LOC105374418 Neighboring gene kelch like family member 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15367 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:39142898-39143092 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:39168330-39169529 Neighboring gene Sharpr-MPRA regulatory region 13789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21454 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21455 Neighboring gene WD repeat domain 19 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:39285877-39286122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Systemic gene expression profiles according to pain types in individuals with chronic spinal cord injury. Morrison D, et al. Mol Pain, 2021 Jan-Dec. PMID 33853401, Free PMC Article
  2. Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets. Mihalič F, et al. Nat Commun, 2023 Sep 13. PMID 37704626, Free PMC Article
  3. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  4. Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Stukalov A, et al. Nature, 2021 Jun. PMID 33845483
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23235

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 156

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303228.2 → NP_001290157.1  transmembrane protein 156 isoform 2

    See identical proteins and their annotated locations for NP_001290157.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
    Source sequence(s)
    AC079921, AK026888, BC030803
    UniProtKB/Swiss-Prot
    Q8N614
    Conserved Domains (1) summary
    pfam15106
    Location:39 → 264
    TMEM156; TMEM156 protein family

  2. NM_024943.3 → NP_079219.1  transmembrane protein 156 isoform 1

    See identical proteins and their annotated locations for NP_079219.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC079921, AK026888, BC030803
    Consensus CDS
    CCDS3448.1
    UniProtKB/Swiss-Prot
    Q8N614, Q9H5N9
    Related
    ENSP00000371364.3, ENST00000381938.4
    Conserved Domains (1) summary
    pfam15106
    Location:39 → 264
    TMEM156; TMEM156 protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    38966744..39032409 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416190.1 → XP_047272146.1  transmembrane protein 156 isoform X7

  2. XM_011513753.3 → XP_011512055.1  transmembrane protein 156 isoform X6

    Conserved Domains (1) summary
    pfam15106
    Location:39 → 236
    TMEM156; TMEM156 protein family

  3. XM_017008629.2 → XP_016864118.1  transmembrane protein 156 isoform X10

    Conserved Domains (1) summary
    pfam15106
    Location:1 → 194
    TMEM156; TMEM156 protein family

  4. XM_047416193.1 → XP_047272149.1  transmembrane protein 156 isoform X10

  5. XM_011513754.3 → XP_011512056.1  transmembrane protein 156 isoform X10

    Conserved Domains (1) summary
    pfam15106
    Location:1 → 194
    TMEM156; TMEM156 protein family

  6. XM_047416189.1 → XP_047272145.1  transmembrane protein 156 isoform X6

  7. XM_047416188.1 → XP_047272144.1  transmembrane protein 156 isoform X2

  8. XM_047416187.1 → XP_047272143.1  transmembrane protein 156 isoform X1

    UniProtKB/Swiss-Prot
    Q8N614, Q9H5N9

  9. XM_047416192.1 → XP_047272148.1  transmembrane protein 156 isoform X9

  10. XM_047416191.1 → XP_047272147.1  transmembrane protein 156 isoform X8

  11. XM_024454224.2 → XP_024309992.1  transmembrane protein 156 isoform X5

    Conserved Domains (1) summary
    pfam15106
    Location:39 → 246
    TMEM156; TMEM156 protein family

  12. XM_024454222.2 → XP_024309990.1  transmembrane protein 156 isoform X3

    Conserved Domains (1) summary
    pfam15106
    Location:39 → 246
    TMEM156; TMEM156 protein family

  13. XM_024454223.2 → XP_024309991.1  transmembrane protein 156 isoform X4

    Conserved Domains (1) summary
    pfam15106
    Location:39 → 246
    TMEM156; TMEM156 protein family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    38936798..39002606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350867.1 → XP_054206842.1  transmembrane protein 156 isoform X1

    UniProtKB/Swiss-Prot
    Q8N614, Q9H5N9

  2. XM_054350876.1 → XP_054206851.1  transmembrane protein 156 isoform X7

  3. XM_054350874.1 → XP_054206849.1  transmembrane protein 156 isoform X6

  4. XM_054350869.1 → XP_054206844.1  transmembrane protein 156 isoform X2

  5. XM_054350879.1 → XP_054206854.1  transmembrane protein 156 isoform X10

  6. XM_054350881.1 → XP_054206856.1  transmembrane protein 156 isoform X10

  7. XM_054350880.1 → XP_054206855.1  transmembrane protein 156 isoform X10

  8. XM_054350875.1 → XP_054206850.1  transmembrane protein 156 isoform X6

  9. XM_054350870.1 → XP_054206845.1  transmembrane protein 156 isoform X2

  10. XM_054350868.1 → XP_054206843.1  transmembrane protein 156 isoform X1

    UniProtKB/Swiss-Prot
    Q8N614, Q9H5N9

  11. XM_054350878.1 → XP_054206853.1  transmembrane protein 156 isoform X9

  12. XM_054350877.1 → XP_054206852.1  transmembrane protein 156 isoform X8

  13. XM_054350873.1 → XP_054206848.1  transmembrane protein 156 isoform X5

  14. XM_054350871.1 → XP_054206846.1  transmembrane protein 156 isoform X3

  15. XM_054350872.1 → XP_054206847.1  transmembrane protein 156 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N614.2 GenPept UniProtKB/Swiss-Prot:Q8N614

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