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MYO15B myosin XVB [ Homo sapiens (human) ]

Gene ID: 80022, updated on 7-Apr-2024

Summary

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Official Symbol
MYO15Bprovided by HGNC
Official Full Name
myosin XVBprovided by HGNC
Primary source
HGNC:HGNC:14083
See related
Ensembl:ENSG00000266714 AllianceGenome:HGNC:14083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYO15BP
Summary
Predicted to enable ATP binding activity; actin binding activity; and cytoskeletal motor activity. Predicted to be located in brush border; cytoplasm; and cytoskeleton. Predicted to be part of myosin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum (RPKM 37.9), small intestine (RPKM 33.6) and 22 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
17q25.1
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (75587800..75626849)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (76480978..76520034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73583881..73622929)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 12010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8971 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:73521300-73521484 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73537609-73538426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:73540787-73541589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73548510-73549090 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553000-73553936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73553937-73554872 Neighboring gene Sharpr-MPRA regulatory region 3602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12768 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12769 Neighboring gene Sharpr-MPRA regulatory region 12965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73583697-73584530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73584531-73585362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73628586-73629266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:73629267-73629946 Neighboring gene RecQ like helicase 5 Neighboring gene Sharpr-MPRA regulatory region 461 Neighboring gene HNF1 motif-containing MPRA enhancer 181 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12771 Neighboring gene small integral membrane protein 5 Neighboring gene small integral membrane protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human myosin XVBP is a transcribed pseudogene. Boger ET, et al. J Muscle Res Cell Motil, 2001. PMID 11964073
  2. A millennial myosin census. Berg JS, et al. Mol Biol Cell, 2001 Apr. PMID 11294886, Free PMC Article
  3. Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products. Nagase T, et al. DNA Res, 2008 Jun 30. PMID 18316326, Free PMC Article
  4. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  5. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. Dias Neto E, et al. Proc Natl Acad Sci U S A, 2000 Mar 28. PMID 10737800, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. myosin XVBP is a transcribed pseudogene (myosin XVBP=MYO15BP)
    Title: Human myosin XVBP is a transcribed pseudogene.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21606, FLJ22686, FLJ40577, FLJ44494, KIAA1783

General protein information

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Preferred Names
myosin XVB
Names
myosin XVB pseudogene
unconventional myosin XVBP pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309242.2 → NP_001296171.1  myosin XVB isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087749, KF511237
    UniProtKB/Swiss-Prot
    Q96JP2
    UniProtKB/TrEMBL
    Q9H614
    Conserved Domains (10) summary
    cd12068
    Location:2447 → 2501
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:2605 → 2743
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:717 → 1356
    MYSc; Myosin. Large ATPases
    smart00295
    Location:2759 → 2955
    B41; Band 4.1 homologues
    cd13201
    Location:2951 → 3052
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cl22853
    Location:734 → 1344
    Motor_domain; Myosin and Kinesin motor domain
    pfam00373
    Location:2844 → 2955
    FERM_M; FERM central domain
    pfam00784
    Location:1560 → 1662
    MyTH4; MyTH4 domain
    cl00936
    Location:165 → 309
    RecX; RecX family
    cl17171
    Location:2349 → 2443
    PH-like; Pleckstrin homology-like domain

  2. NM_001395058.1 → NP_001381987.1  myosin XVB isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC087749, KF511237
    Consensus CDS
    CCDS92396.1
    UniProtKB/Swiss-Prot
    A0A0J9YVZ6, A0A2R8YFM0, Q96JP2
    Related
    ENSP00000495242.3, ENST00000645453.3
    Conserved Domains (9) summary
    cd12068
    Location:2485 → 2539
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:2643 → 2781
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:2797 → 2993
    B41; Band 4.1 homologues
    PHA03307
    Location:9 → 358
    PHA03307; transcriptional regulator ICP4; Provisional
    PRK12678
    Location:272 → 494
    PRK12678; transcription termination factor Rho; Provisional
    cd13201
    Location:2989 → 3090
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14896
    Location:734 → 1382
    MYSc_Myo35; class XXXV myosin, motor domain
    cl02480
    Location:1555 → 1700
    MyTH4; MyTH4 domain
    cl17171
    Location:2387 → 2481
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    75587800..75626849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025120.3 → XP_016880609.1  myosin XVB isoform X1

  2. XM_017025123.3 → XP_016880612.1  myosin XVB isoform X4

  3. XM_017025125.3 → XP_016880614.1  myosin XVB isoform X6

  4. XM_017025124.3 → XP_016880613.1  myosin XVB isoform X5

  5. XM_017025122.3 → XP_016880611.1  myosin XVB isoform X3

  6. XM_017025121.3 → XP_016880610.1  myosin XVB isoform X2

  7. XM_017025127.3 → XP_016880616.1  myosin XVB isoform X8

  8. XM_047436788.1 → XP_047292744.1  myosin XVB isoform X7

  9. XM_047436789.1 → XP_047292745.1  myosin XVB isoform X10

  10. XM_047436795.1 → XP_047292751.1  myosin XVB isoform X19

  11. XM_047436796.1 → XP_047292752.1  myosin XVB isoform X22

  12. XM_047436798.1 → XP_047292754.1  myosin XVB isoform X26

  13. XM_017025128.3 → XP_016880617.1  myosin XVB isoform X9

  14. XM_047436792.1 → XP_047292748.1  myosin XVB isoform X16

  15. XM_017025131.3 → XP_016880620.1  myosin XVB isoform X13

  16. XM_047436790.1 → XP_047292746.1  myosin XVB isoform X14

  17. XM_017025129.3 → XP_016880618.1  myosin XVB isoform X11

  18. XM_047436791.1 → XP_047292747.1  myosin XVB isoform X15

  19. XM_017025130.3 → XP_016880619.1  myosin XVB isoform X12

  20. XM_047436793.1 → XP_047292749.1  myosin XVB isoform X17

  21. XM_047436794.1 → XP_047292750.1  myosin XVB isoform X18

  22. XM_017025135.3 → XP_016880624.1  myosin XVB isoform X20

    UniProtKB/TrEMBL
    A0A286YF23
    Related
    ENST00000633867.1

  23. XM_017025136.3 → XP_016880625.1  myosin XVB isoform X20

    UniProtKB/TrEMBL
    A0A286YF23

  24. XM_017025137.3 → XP_016880626.1  myosin XVB isoform X21

    UniProtKB/TrEMBL
    A0A286YF23

  25. XM_047436797.1 → XP_047292753.1  myosin XVB isoform X24

  26. XM_017025138.3 → XP_016880627.1  myosin XVB isoform X23

    UniProtKB/TrEMBL
    A0A286YF23

  27. XM_017025140.3 → XP_016880629.1  myosin XVB isoform X25

    UniProtKB/TrEMBL
    A0A286YF23
    Related
    ENSP00000492911.2, ENST00000642007.2

  28. XM_017025143.3 → XP_016880632.1  myosin XVB isoform X27

    UniProtKB/TrEMBL
    A0A286YF23

  29. XM_024450952.2 → XP_024306720.1  myosin XVB isoform X28

    UniProtKB/TrEMBL
    A0A286YF23
    Conserved Domains (5) summary
    cd12068
    Location:802 → 856
    SH3_MYO15B; Src Homology 3 domain of Myosin XVb
    smart00139
    Location:960 → 1098
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:1114 → 1310
    B41; Band 4.1 homologues
    cd13201
    Location:1306 → 1407
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cl17171
    Location:704 → 798
    PH-like; Pleckstrin homology-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    76480978..76520034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317332.1 → XP_054173307.1  myosin XVB isoform X26

  2. XM_054317328.1 → XP_054173303.1  myosin XVB isoform X22

  3. XM_054317324.1 → XP_054173299.1  myosin XVB isoform X19

  4. XM_054317314.1 → XP_054173289.1  myosin XVB isoform X10

  5. XM_054317309.1 → XP_054173284.1  myosin XVB isoform X7

  6. XM_054317306.1 → XP_054173281.1  myosin XVB isoform X4

  7. XM_054317303.1 → XP_054173278.1  myosin XVB isoform X1

  8. XM_054317307.1 → XP_054173282.1  myosin XVB isoform X5

  9. XM_054317305.1 → XP_054173280.1  myosin XVB isoform X3

  10. XM_054317304.1 → XP_054173279.1  myosin XVB isoform X2

  11. XM_054317308.1 → XP_054173283.1  myosin XVB isoform X6

  12. XM_054317310.1 → XP_054173285.1  myosin XVB isoform X29

  13. XM_054317311.1 → XP_054173286.1  myosin XVB isoform X30

  14. XM_054317312.1 → XP_054173287.1  myosin XVB isoform X8

  15. XM_054317313.1 → XP_054173288.1  myosin XVB isoform X9

  16. XM_054317320.1 → XP_054173295.1  myosin XVB isoform X16

  17. XM_054317317.1 → XP_054173292.1  myosin XVB isoform X13

  18. XM_054317318.1 → XP_054173293.1  myosin XVB isoform X14

  19. XM_054317315.1 → XP_054173290.1  myosin XVB isoform X11

  20. XM_054317319.1 → XP_054173294.1  myosin XVB isoform X15

  21. XM_054317316.1 → XP_054173291.1  myosin XVB isoform X12

  22. XM_054317321.1 → XP_054173296.1  myosin XVB isoform X17

  23. XM_054317322.1 → XP_054173297.1  myosin XVB isoform X18

  24. XM_054317326.1 → XP_054173301.1  myosin XVB isoform X20

  25. XM_054317323.1 → XP_054173298.1  myosin XVB isoform X31

  26. XM_054317325.1 → XP_054173300.1  myosin XVB isoform X20

  27. XM_054317327.1 → XP_054173302.1  myosin XVB isoform X21

  28. XM_054317330.1 → XP_054173305.1  myosin XVB isoform X24

  29. XM_054317329.1 → XP_054173304.1  myosin XVB isoform X23

  30. XM_054317334.1 → XP_054173309.1  myosin XVB isoform X32

  31. XM_054317333.1 → XP_054173308.1  myosin XVB isoform X32

  32. XM_054317331.1 → XP_054173306.1  myosin XVB isoform X25

  33. XM_054317335.1 → XP_054173310.1  myosin XVB isoform X27

  34. XM_054317336.1 → XP_054173311.1  myosin XVB isoform X28

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080847.1: Suppressed sequence

    Description
    NM_001080847.1: This RefSeq was permanently suppressed because it is now thought that this gene is a pseudogene.

  2. NR_003587.2: Suppressed sequence

    Description
    NR_003587.2: This RefSeq was removed because it is now thought that this gene does encode a protein.
Nucleotide Protein
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