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BAIAP2L2 BAR/IMD domain containing adaptor protein 2 like 2 [ Homo sapiens (human) ]

Gene ID: 80115, updated on 3-Apr-2024

Summary

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Official Symbol
BAIAP2L2provided by HGNC
Official Full Name
BAR/IMD domain containing adaptor protein 2 like 2provided by HGNC
Primary source
HGNC:HGNC:26203
See related
Ensembl:ENSG00000128298 MIM:617536; AllianceGenome:HGNC:26203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene binds phosphoinositides and promotes the formation of planar or curved membrane structures. The encoded protein is found in RAB13-positive vesicles and at intercellular contacts with the plasma membrane. [provided by RefSeq, Dec 2012]
Expression
Biased expression in duodenum (RPKM 28.1), small intestine (RPKM 24.8) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
22q13.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38084900..38110967, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38546488..38574157, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38480907..38506691, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38452863-38453488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38453489-38454112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38470967-38471468 Neighboring gene protein interacting with PRKCA 1 Neighboring gene uncharacterized LOC105373027 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38476553-38477334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38479675-38480456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38482017-38482796 Neighboring gene solute carrier family 16 member 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38494339-38494893 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:38510521-38511423 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38518609-38519118 Neighboring gene phospholipase A2 group VI Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38538756-38539256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18993 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38559728-38560228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38560229-38560729 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38561911 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38570189 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38572440 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18996 Neighboring gene Sharpr-MPRA regulatory region 6169 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38580917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18999 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13709 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38600595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13710 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38603571 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607237 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38607534 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 22:38608227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:38609813-38610394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13712 Neighboring gene MAF bZIP transcription factor F Neighboring gene transmembrane protein 184B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis. Wei H, et al. Sci Rep, 2023 May 29. PMID 37248248, Free PMC Article
  2. BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways. Song Y, et al. Genes Genomics, 2021 Apr. PMID 33646530
  3. BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer. Xu L, et al. Oncol Rep, 2019 Feb. PMID 30483805
  4. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways. Liu J, et al. Biomed Pharmacother, 2020 Sep. PMID 32570120
  5. Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Pykäläinen A, et al. Nat Struct Mol Biol, 2011 Jul 10. PMID 21743456, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.
    Title: BAIAP2L2 is a novel prognostic biomarker related to migration and invasion of HCC and associated with cuprotosis.
  2. HNF1beta-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
    Title: HNF1β-associated cyst development and electrolyte disturbances are not explained by BAIAP2L2 expression.
  3. BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways.
    Title: BAIAP2L2 facilitates the malignancy of prostate cancer (PCa) via VEGF and apoptosis signaling pathways.
  4. BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/beta-catenin signaling pathways.
    Title: BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
  5. these findings revealed BAIAP2L2 as a novel biomarker and potential therapeutic target for lung cancer
    Title: BAI1‑associated protein 2‑like 2 is a potential biomarker in lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22582

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin crosslink formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell-cell contact zone IDA
Inferred from Direct Assay
more info
 PubMed 
part_of clathrin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2
Names
BAI1 associated protein 2 like 2
BAI1-associated protein 2-like protein 2
pinkbar
planar intestinal- and kidney-specific BAR domain protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033059.2 RefSeqGene

    Range
    4986..30770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_025045.6 → NP_079321.3  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2

    See identical proteins and their annotated locations for NP_079321.3

    Status: REVIEWED

    Source sequence(s)
    AL022322, AW007403, AY358164, KF457452
    Consensus CDS
    CCDS43018.1
    UniProtKB/Swiss-Prot
    B0QYE2, Q6UXY1, Q96BG7
    Related
    ENSP00000371085.3, ENST00000381669.8
    Conserved Domains (2) summary
    cd07644
    Location:6 → 220
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cd11914
    Location:331 → 385
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    38084900..38110967 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261751.5 → XP_005261808.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X6

    See identical proteins and their annotated locations for XP_005261808.1

    UniProtKB/Swiss-Prot
    B0QYE2, Q6UXY1, Q96BG7
    Conserved Domains (2) summary
    cd07644
    Location:6 → 220
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cd11914
    Location:331 → 385
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2

  2. XM_011530379.4 → XP_011528681.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6UXY1
    Conserved Domains (3) summary
    cd07644
    Location:6 → 220
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cd11914
    Location:331 → 385
    SH3_BAIAP2L2; Src Homology 3 domain of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cl41728
    Location:499 → 514
    WH2; Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins

  3. XM_011530384.3 → XP_011528686.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X5

    Conserved Domains (2) summary
    cl12013
    Location:63 → 190
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:301 → 355
    SH3; Src Homology 3 domain superfamily

  4. XM_011530381.3 → XP_011528683.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011528683.1

    Conserved Domains (2) summary
    cd07644
    Location:1 → 201
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cl17036
    Location:312 → 366
    SH3; Src Homology 3 domain superfamily

  5. XM_011530383.3 → XP_011528685.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X4

    Conserved Domains (2) summary
    cl12013
    Location:69 → 196
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:307 → 361
    SH3; Src Homology 3 domain superfamily

  6. XM_011530382.3 → XP_011528684.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

    See identical proteins and their annotated locations for XP_011528684.1

    Conserved Domains (2) summary
    cd07644
    Location:1 → 201
    I-BAR_IMD_BAIAP2L2; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Brain-specific Angiogenesis Inhibitor 1-Associated Protein 2-Like 2
    cl17036
    Location:312 → 366
    SH3; Src Homology 3 domain superfamily

  7. XM_011530380.4 → XP_011528682.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

    Conserved Domains (2) summary
    cl12013
    Location:75 → 202
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl17036
    Location:313 → 367
    SH3; Src Homology 3 domain superfamily

  8. XM_011530388.3 → XP_011528690.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X8

    Conserved Domains (1) summary
    cl17036
    Location:124 → 178
    SH3; Src Homology 3 domain superfamily

  9. XM_011530387.4 → XP_011528689.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011528689.1

    UniProtKB/TrEMBL
    A0A804CBC2
    Conserved Domains (1) summary
    cl17036
    Location:136 → 190
    SH3; Src Homology 3 domain superfamily

  10. XM_011530386.3 → XP_011528688.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X7

    See identical proteins and their annotated locations for XP_011528688.1

    UniProtKB/TrEMBL
    A0A804CBC2
    Conserved Domains (1) summary
    cl17036
    Location:136 → 190
    SH3; Src Homology 3 domain superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38546488..38574157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325926.1 → XP_054181901.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X6

    UniProtKB/Swiss-Prot
    B0QYE2, Q6UXY1, Q96BG7

  2. XM_054325920.1 → XP_054181895.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X1

  3. XM_054325925.1 → XP_054181900.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X5

  4. XM_054325922.1 → XP_054181897.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

  5. XM_054325924.1 → XP_054181899.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X4

  6. XM_054325923.1 → XP_054181898.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X3

  7. XM_054325921.1 → XP_054181896.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X2

  8. XM_054325929.1 → XP_054181904.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X8

  9. XM_054325928.1 → XP_054181903.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X7

  10. XM_054325927.1 → XP_054181902.1  brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6UXY1.1 GenPept UniProtKB/Swiss-Prot:Q6UXY1

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