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MYCT1 MYC target 1 [ Homo sapiens (human) ]

Gene ID: 80177, updated on 12-Nov-2024

Summary

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Official Symbol
MYCT1provided by HGNC
Official Full Name
MYC target 1provided by HGNC
Primary source
HGNC:HGNC:23172
See related
Ensembl:ENSG00000120279 MIM:616805; AllianceGenome:HGNC:23172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTLC
Summary
Predicted to act upstream of or within hematopoietic stem cell homeostasis. Located in nuclear body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen (RPKM 14.8), fat (RPKM 8.8) and 22 other tissues See more
Orthologs
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Genomic context

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See MYCT1 in Genome Data Viewer
Location:
6q25.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (152697897..152747181)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (153899213..153948502)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153019032..153049320)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene NANOG hESC enhancer GRCh37_chr6:152893840-152894402 Neighboring gene Nanog homeobox pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25289 Neighboring gene uncharacterized LOC105378061 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:153042324-153043523 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 2840 Neighboring gene uncharacterized LOC124901440 Neighboring gene vasoactive intestinal peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MYCT-1 Gene Expression in Patients with Gastric Cancer: an Ex Vivo Study. Dong X, et al. Appl Biochem Biotechnol, 2024 Aug. PMID 38112991
  2. [Cloning and characterization of MTLC, a novel gene in 6q25]. Qiu G, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2003 Apr. PMID 12673574
  3. Expression of MTLC gene in gastric carcinoma. Qiu GB, et al. World J Gastroenterol, 2003 Oct. PMID 14562369, Free PMC Article
  4. Promoter hypermethylation-induced transcriptional down-regulation of the gene MYCT1 in laryngeal squamous cell carcinoma. Yang M, et al. BMC Cancer, 2012 Jun 6. PMID 22672838, Free PMC Article
  5. Transmembrane domain is crucial to the subcellular localization and function of Myc target 1. Wu S, et al. J Cell Mol Med, 2016 Mar. PMID 26710964, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MYCT-1 Gene Expression in Patients with Gastric Cancer: an Ex Vivo Study.
    Title: MYCT-1 Gene Expression in Patients with Gastric Cancer: an Ex Vivo Study.
  2. MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
    Title: MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
  3. MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
    Title: MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
  4. Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
    Title: Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
  5. MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
    Title: MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
  6. Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
    Title: Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
  7. MYCT1 may synergistically interact with MAX as a co-transcription factor or a component of MAX transcriptional complex, to transcriptionally regulate the expression of miR-181a, which, in turn, decreases NPM1 expression at post-transcriptional levels, leading to enhanced apoptosis in laryngeal cancer cells
    Title: MYCT1 represses apoptosis of laryngeal cancerous cells through the MAX/miR-181a/NPM1 pathway.
  8. miR-632 was upregulated and MYCT1 was downregulated in HCC. High miR-632 or low MYCT1 expression was shown as a predictor for poor overall survival of HCC patients. The study also found miR-632 was able to regulate HCC cell growth and invasion through targeting the expression of MYCT1.
    Title: miR-632 Functions as Oncogene in Hepatocellular Carcinoma via Targeting MYCT1.
  9. YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression.
    Title: YY1 directly suppresses MYCT1 leading to laryngeal tumorigenesis and progress.
  10. Overexpression of MYCT1, decreased cell viability under serum deprivation and increased tumour cell migration ability.
    Title: Transmembrane domain is crucial to the subcellular localization and function of Myc target 1.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21269, MGC156309, MGC156310

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in hematopoietic stem cell homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
myc target protein 1
Names
myc target in myeloid cells 1
myc target in myeloid cells protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371624.1 → NP_001358553.1  myc target protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390960
    UniProtKB/TrEMBL
    D6Q1S4, H0YDV5
    Conserved Domains (1) summary
    pfam15179
    Location:1 → 186
    Myc_target_1; Myc target protein 1

  2. NM_001371625.1 → NP_001358554.1  myc target protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390960
    UniProtKB/TrEMBL
    D6Q1S4, H0YDV5
    Conserved Domains (1) summary
    pfam15179
    Location:1 → 186
    Myc_target_1; Myc target protein 1

  3. NM_001371626.1 → NP_001358555.1  myc target protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL390960
    UniProtKB/TrEMBL
    D6Q1S4, H0YDV5
    Related
    ENSP00000434396.1, ENST00000532295.1
    Conserved Domains (1) summary
    pfam15179
    Location:1 → 186
    Myc_target_1; Myc target protein 1

  4. NM_025107.3 → NP_079383.2  myc target protein 1 isoform 1

    See identical proteins and their annotated locations for NP_079383.2

    Status: VALIDATED

    Source sequence(s)
    AL390960
    Consensus CDS
    CCDS5239.1
    UniProtKB/Swiss-Prot
    Q8N396, Q8N699, Q8TBE8, Q9H763
    UniProtKB/TrEMBL
    H0YDV5
    Related
    ENSP00000356214.5, ENST00000367245.6
    Conserved Domains (1) summary
    pfam15179
    Location:49 → 234
    Myc_target_1; Myc target protein 1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    152697897..152747181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_007059337.1 RNA Sequence

  2. XR_007059339.1 RNA Sequence

  3. XR_007059338.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    153899213..153948502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008487435.1 RNA Sequence

  2. XR_008487437.1 RNA Sequence

  3. XR_008487436.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N699.1 GenPept UniProtKB/Swiss-Prot:Q8N699

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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