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MYO19 myosin XIX [ Homo sapiens (human) ]

Gene ID: 80179, updated on 28-Oct-2024

Summary

Official Symbol
MYO19provided by HGNC
Official Full Name
myosin XIXprovided by HGNC
Primary source
HGNC:HGNC:26234
See related
Ensembl:ENSG00000278259 MIM:617379; AllianceGenome:HGNC:26234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MYOHD1
Summary
Enables ATP hydrolysis activity and actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See MYO19 in Genome Data Viewer
Location:
17q12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36495636..36544815, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37481389..37530568, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34851480..34890695, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34842246-34843179 Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34889386-34890061 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22865

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables myosin light chain binding IEA
Inferred from Electronic Annotation
more info
 
enables plus-end directed microfilament motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within mitochondrion migration along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
unconventional myosin-XIX
Names
myosin head domain containing 1
myosin head domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033580.3NP_001028752.1  unconventional myosin-XIX isoform 3

    See identical proteins and their annotated locations for NP_001028752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 3' coding region, 3' UTR, and poly-adenylation signal, compared to variant 2. The resulting isoform (3) has a substantially shorter and distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS59283.1
    Related
    ENSP00000477559.1, ENST00000621344.4
    Conserved Domains (1) summary
    cl22853
    Location:49299
    Motor_domain; Myosin and Kinesin motor domain
  2. NM_001163735.2NP_001157207.1  unconventional myosin-XIX isoform 2

    See identical proteins and their annotated locations for NP_001157207.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS54112.1
    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
    UniProtKB/TrEMBL
    B4E218
    Related
    ENSP00000479518.1, ENST00000614623.5
    Conserved Domains (2) summary
    smart00242
    Location:36754
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49746
    MYSc_Myo19; class XIX myosin, motor domain
  3. NM_025109.6NP_079385.2  unconventional myosin-XIX isoform 1

    See identical proteins and their annotated locations for NP_079385.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame segment, compared to variant 2. The resulting isoform (1) lacks an internal segment in the central coding region, compared to isoform 2.
    Source sequence(s)
    AC233698
    Consensus CDS
    CCDS45654.1
    UniProtKB/Swiss-Prot
    Q96H55
    UniProtKB/TrEMBL
    B4E218, B7Z1T7
    Related
    ENSP00000478437.1, ENST00000610930.4
    Conserved Domains (1) summary
    cl22853
    Location:49439
    Motor_domain; Myosin and Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    36495636..36544815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436823.1XP_047292779.1  unconventional myosin-XIX isoform X1

  2. XM_047436835.1XP_047292791.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  3. XM_047436826.1XP_047292782.1  unconventional myosin-XIX isoform X4

  4. XM_024450955.2XP_024306723.1  unconventional myosin-XIX isoform X1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  5. XM_047436840.1XP_047292796.1  unconventional myosin-XIX isoform X16

  6. XM_047436839.1XP_047292795.1  unconventional myosin-XIX isoform X15

  7. XM_047436830.1XP_047292786.1  unconventional myosin-XIX isoform X9

  8. XM_017025158.3XP_016880647.1  unconventional myosin-XIX isoform X4

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49792
    MYSc_Myo19; class XIX myosin, motor domain
  9. XM_047436837.1XP_047292793.1  unconventional myosin-XIX isoform X13

  10. XM_011525290.4XP_011523592.1  unconventional myosin-XIX isoform X6

    See identical proteins and their annotated locations for XP_011523592.1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (2) summary
    smart00242
    Location:36785
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49777
    MYSc_Myo19; class XIX myosin, motor domain
  11. XM_047436836.1XP_047292792.1  unconventional myosin-XIX isoform X12

  12. XM_017025159.3XP_016880648.1  unconventional myosin-XIX isoform X5

    UniProtKB/TrEMBL
    B4E218
  13. XM_011525287.3XP_011523589.1  unconventional myosin-XIX isoform X2

    See identical proteins and their annotated locations for XP_011523589.1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (2) summary
    smart00242
    Location:36829
    MYSc; Myosin. Large ATPases
    cd14880
    Location:49821
    MYSc_Myo19; class XIX myosin, motor domain
  14. XM_017025160.3XP_016880649.1  unconventional myosin-XIX isoform X11

    UniProtKB/TrEMBL
    B4E218
  15. XM_011525286.3XP_011523588.1  unconventional myosin-XIX isoform X1

    See identical proteins and their annotated locations for XP_011523588.1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  16. XM_047436838.1XP_047292794.1  unconventional myosin-XIX isoform X14

  17. XM_047436829.1XP_047292785.1  unconventional myosin-XIX isoform X8

  18. XM_047436828.1XP_047292784.1  unconventional myosin-XIX isoform X7

  19. XM_047436824.1XP_047292780.1  unconventional myosin-XIX isoform X21

  20. XM_047436825.1XP_047292781.1  unconventional myosin-XIX isoform X3

  21. XM_047436842.1XP_047292798.1  unconventional myosin-XIX isoform X16

  22. XM_047436834.1XP_047292790.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  23. XM_047436832.1XP_047292788.1  unconventional myosin-XIX isoform X9

  24. XM_017025157.2XP_016880646.1  unconventional myosin-XIX isoform X1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  25. XM_047436841.1XP_047292797.1  unconventional myosin-XIX isoform X16

  26. XM_047436833.1XP_047292789.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  27. XM_047436831.1XP_047292787.1  unconventional myosin-XIX isoform X9

  28. XM_024450956.2XP_024306724.1  unconventional myosin-XIX isoform X4

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49792
    MYSc_Myo19; class XIX myosin, motor domain
  29. XM_047436827.1XP_047292783.1  unconventional myosin-XIX isoform X6

  30. XM_024450954.2XP_024306722.1  unconventional myosin-XIX isoform X1

    UniProtKB/TrEMBL
    B4E218
    Conserved Domains (1) summary
    cd14880
    Location:49823
    MYSc_Myo19; class XIX myosin, motor domain
  31. XM_047436844.1XP_047292800.1  unconventional myosin-XIX isoform X18

  32. XM_047436843.1XP_047292799.1  unconventional myosin-XIX isoform X17

  33. XM_047436845.1XP_047292801.1  unconventional myosin-XIX isoform X19

    Related
    ENSP00000480125.1, ENST00000610992.4
  34. XM_047436846.1XP_047292802.1  unconventional myosin-XIX isoform X20

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    730540..779719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329348.1XP_054185323.1  unconventional myosin-XIX isoform X1

  2. XM_054329363.1XP_054185338.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  3. XM_054329362.1XP_054185337.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  4. XM_054329364.1XP_054185339.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  5. XM_054329353.1XP_054185328.1  unconventional myosin-XIX isoform X4

  6. XM_054329345.1XP_054185320.1  unconventional myosin-XIX isoform X1

  7. XM_054329372.1XP_054185347.1  unconventional myosin-XIX isoform X16

  8. XM_054329361.1XP_054185336.1  unconventional myosin-XIX isoform X9

  9. XM_054329344.1XP_054185319.1  unconventional myosin-XIX isoform X1

  10. XM_054329360.1XP_054185335.1  unconventional myosin-XIX isoform X9

  11. XM_054329370.1XP_054185345.1  unconventional myosin-XIX isoform X16

  12. XM_054329369.1XP_054185344.1  unconventional myosin-XIX isoform X15

  13. XM_054329359.1XP_054185334.1  unconventional myosin-XIX isoform X9

  14. XM_054329351.1XP_054185326.1  unconventional myosin-XIX isoform X4

  15. XM_054329367.1XP_054185342.1  unconventional myosin-XIX isoform X13

  16. XM_054329355.1XP_054185330.1  unconventional myosin-XIX isoform X6

  17. XM_054329366.1XP_054185341.1  unconventional myosin-XIX isoform X12

  18. XM_054329354.1XP_054185329.1  unconventional myosin-XIX isoform X5

  19. XM_054329349.1XP_054185324.1  unconventional myosin-XIX isoform X2

  20. XM_054329365.1XP_054185340.1  unconventional myosin-XIX isoform X11

  21. XM_054329346.1XP_054185321.1  unconventional myosin-XIX isoform X1

  22. XM_054329371.1XP_054185346.1  unconventional myosin-XIX isoform X16

  23. XM_054329352.1XP_054185327.1  unconventional myosin-XIX isoform X4

  24. XM_054329356.1XP_054185331.1  unconventional myosin-XIX isoform X6

  25. XM_054329347.1XP_054185322.1  unconventional myosin-XIX isoform X1

  26. XM_054329368.1XP_054185343.1  unconventional myosin-XIX isoform X14

  27. XM_054329358.1XP_054185333.1  unconventional myosin-XIX isoform X8

  28. XM_054329357.1XP_054185332.1  unconventional myosin-XIX isoform X7

  29. XM_054329350.1XP_054185325.1  unconventional myosin-XIX isoform X3

  30. XM_054329374.1XP_054185349.1  unconventional myosin-XIX isoform X18

  31. XM_054329373.1XP_054185348.1  unconventional myosin-XIX isoform X17

  32. XM_054329375.1XP_054185350.1  unconventional myosin-XIX isoform X19

  33. XM_054329376.1XP_054185351.1  unconventional myosin-XIX isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    37481389..37530568 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317373.1XP_054173348.1  unconventional myosin-XIX isoform X1

  2. XM_054317388.1XP_054173363.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  3. XM_054317387.1XP_054173362.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  4. XM_054317389.1XP_054173364.1  unconventional myosin-XIX isoform X10

    UniProtKB/Swiss-Prot
    Q59GS4, Q96H55, Q9H5X2
  5. XM_054317378.1XP_054173353.1  unconventional myosin-XIX isoform X4

  6. XM_054317372.1XP_054173347.1  unconventional myosin-XIX isoform X1

  7. XM_054317397.1XP_054173372.1  unconventional myosin-XIX isoform X16

  8. XM_054317386.1XP_054173361.1  unconventional myosin-XIX isoform X9

  9. XM_054317369.1XP_054173344.1  unconventional myosin-XIX isoform X1

  10. XM_054317385.1XP_054173360.1  unconventional myosin-XIX isoform X9

  11. XM_054317395.1XP_054173370.1  unconventional myosin-XIX isoform X16

  12. XM_054317394.1XP_054173369.1  unconventional myosin-XIX isoform X15

  13. XM_054317384.1XP_054173359.1  unconventional myosin-XIX isoform X9

  14. XM_054317376.1XP_054173351.1  unconventional myosin-XIX isoform X4

  15. XM_054317392.1XP_054173367.1  unconventional myosin-XIX isoform X13

  16. XM_054317380.1XP_054173355.1  unconventional myosin-XIX isoform X6

  17. XM_054317391.1XP_054173366.1  unconventional myosin-XIX isoform X12

  18. XM_054317379.1XP_054173354.1  unconventional myosin-XIX isoform X5

  19. XM_054317374.1XP_054173349.1  unconventional myosin-XIX isoform X2

  20. XM_054317390.1XP_054173365.1  unconventional myosin-XIX isoform X11

  21. XM_054317370.1XP_054173345.1  unconventional myosin-XIX isoform X1

  22. XM_054317396.1XP_054173371.1  unconventional myosin-XIX isoform X16

  23. XM_054317377.1XP_054173352.1  unconventional myosin-XIX isoform X4

  24. XM_054317381.1XP_054173356.1  unconventional myosin-XIX isoform X6

  25. XM_054317371.1XP_054173346.1  unconventional myosin-XIX isoform X1

  26. XM_054317393.1XP_054173368.1  unconventional myosin-XIX isoform X14

  27. XM_054317383.1XP_054173358.1  unconventional myosin-XIX isoform X8

  28. XM_054317382.1XP_054173357.1  unconventional myosin-XIX isoform X7

  29. XM_054317375.1XP_054173350.1  unconventional myosin-XIX isoform X3

  30. XM_054317399.1XP_054173374.1  unconventional myosin-XIX isoform X18

  31. XM_054317398.1XP_054173373.1  unconventional myosin-XIX isoform X17

  32. XM_054317400.1XP_054173375.1  unconventional myosin-XIX isoform X19

  33. XM_054317401.1XP_054173376.1  unconventional myosin-XIX isoform X20

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033579.1: Suppressed sequence

    Description
    NM_001033579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.