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Zxdc ZXD family zinc finger C [ Mus musculus (house mouse) ]

Gene ID: 80292, updated on 2-Nov-2024

Summary

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Official Symbol
Zxdcprovided by MGI
Official Full Name
ZXD family zinc finger Cprovided by MGI
Primary source
MGI:MGI:1933108
See related
Ensembl:ENSMUSG00000034430 AllianceGenome:MGI:1933108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930012H20; B930086F11Rik
Summary
Predicted to enable C2H2 zinc finger domain binding activity; LRR domain binding activity; and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and gonad. Orthologous to human ZXDC (ZXD family zinc finger C). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 12.4), adrenal adult (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zxdc in Genome Data Viewer
Location:
6 D1; 6 40.16 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90346460..90380472)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90369478..90403490)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 13 Neighboring gene urocanase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene cilia and flagella associated protein 100 Neighboring gene predicted gene, 53295 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene Kruppel-like transcription factor 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cell-fate transition and determination analysis of mouse male germ cells throughout development. Zhao J, et al. Nat Commun, 2021 Nov 25. PMID 34824237, Free PMC Article
  2. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC7160

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C2H2 zinc finger domain binding ISO
Inferred from Sequence Orthology
more info
  
enables C2H2 zinc finger domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables LRR domain binding ISO
Inferred from Sequence Orthology
more info
  
enables LRR domain binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein ZXDC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030260.3 → NP_084536.2  zinc finger protein ZXDC isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter protein (isoform 1).
    Source sequence(s)
    AC163346, AK042190, AK044429, AK081005
    Consensus CDS
    CCDS51848.1
    UniProtKB/Swiss-Prot
    Q8C8V1
    Related
    ENSMUSP00000109167.3, ENSMUST00000113539.8
    Conserved Domains (4) summary
    COG5048
    Location:392 → 691
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:226 → 252
    zf-H2C2_2; Zinc-finger double domain
    pfam17017
    Location:209 → 354
    zf-C2H2_aberr; Aberrant zinc-finger

  2. NM_173002.3 → NP_766590.1  zinc finger protein ZXDC isoform 2

    See identical proteins and their annotated locations for NP_766590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has additional exons in the 3' coding region and UTR. The resulting protein (isoform 2) is longer and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK044429, AK044529, AK081005
    Consensus CDS
    CCDS20358.1
    UniProtKB/Swiss-Prot
    Q3TEP2, Q3URC2, Q8C4U7, Q8C4Z9, Q8C8C2, Q8C8T1, Q8C8V1, Q99J65
    Related
    ENSMUSP00000074619.4, ENSMUST00000075117.10
    Conserved Domains (4) summary
    COG5048
    Location:176 → 363
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:334 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:376 → 402
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:241 → 318
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    90346460..90380472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_377502.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C8V1.1 GenPept UniProtKB/Swiss-Prot:Q8C8V1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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