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RASSF7 Ras association domain family member 7 [ Homo sapiens (human) ]

Gene ID: 8045, updated on 5-Mar-2024

Summary

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Official Symbol
RASSF7provided by HGNC
Official Full Name
Ras association domain family member 7provided by HGNC
Primary source
HGNC:HGNC:1166
See related
Ensembl:ENSG00000099849 MIM:143023; AllianceGenome:HGNC:1166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRC1; FAP88; HRAS1; CFAP88; C11orf13
Summary
Predicted to be involved in apoptotic process; regulation of microtubule cytoskeleton organization; and signal transduction. Located in centriolar satellite. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach (RPKM 14.8), colon (RPKM 12.6) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
11p15.5
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (560970..564025)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (607974..611029)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (560970..564025)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 56 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:533792-534649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:534650-535506 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:535528-536235 Neighboring gene HRas proto-oncogene, GTPase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:540668-541490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:543860-544362 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:544865-545366 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr11:548147-548965 and GRCh37_chr11:548966-549783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:556675-557511 Neighboring gene lamin tail domain containing 2 Neighboring gene LMNTD2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:561773-562348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:565694-566248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:566249-566803 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:569389-570139 Neighboring gene MIR210 host gene Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 210 Neighboring gene uncharacterized LOC143666

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration. Liu ZH, et al. Int J Clin Exp Pathol, 2015. PMID 26884887, Free PMC Article
  2. RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7. Takahashi S, et al. Cell Death Differ, 2011 Apr. PMID 21278800, Free PMC Article
  3. The HRAS1 gene cluster: two upstream regions recognizing transcripts and a third encoding a gene with a leucine zipper domain. Weitzel JN, et al. Genomics, 1992 Oct. PMID 1339391
  4. Truncated RASSF7 promotes centrosomal defects and cell death. Gulsen T, et al. Dev Biol, 2016 Jan 15. PMID 26569555
  5. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Recino A, et al. Biochem J, 2010 Sep 1. PMID 20629633, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RASSF7 competed with MAX in the formation of a heterodimeric complex with c-Myc and attenuated its occupancy on target gene promoters to regulate transcription.
    Title: The non-enzymatic RAS effector RASSF7 inhibits oncogenic c-Myc function.
  2. RASSF7 promotes cell proliferation through activating MEK1/MEK2-ERK1/ERK2 signaling pathway in hepatocellular carcinoma.
    Title: RASSF7 promotes cell proliferation through activating MEK1/2-ERK1/2 signaling pathway in hepatocellular carcinoma.
  3. Suggest that loss of RASSF7 expression results in apoptosis in nucleus pulposus cells in human intervertebral disc degeneration.
    Title: RASSF7 expression and its regulatory roles on apoptosis in human intervertebral disc degeneration.
  4. truncated RASSF7 could act as an oncogene in a small subset of tumours where it is mutated in this way.
    Title: Truncated RASSF7 promotes centrosomal defects and cell death.
  5. The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.
    Title: The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastoma.
  6. RASSF7 acts in concert with N-Ras to constitute a stress-sensitive temporary mechanism of apoptotic regulation.
    Title: RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7.
  7. RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.
    Title: Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis.
  8. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
    Title: Human longevity and 11p15.5: a study in 1321 centenarians.
  9. "rare" alleles of HRas1 minisatellite are associated with increased risk of papillary thyroid cancer formation in children and adolescents after Chernobyl accident
    Title: [Study of HRas1 minisatellite frequencies in children with thyroid papillary cancer].
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126069, MGC126070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 7
Names
HRAS1-related cluster protein 1
HRAS1-related cluster-1
Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
Ras association (RalGDS/AF-6) domain family 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143993.2 → NP_001137465.1  ras association domain-containing protein 7 isoform 2

    See identical proteins and their annotated locations for NP_001137465.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the 5' UTR and 3' coding region, compared to variant 1. These differences result in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL535761, AP006284, BC106921, CA315057
    Consensus CDS
    CCDS44506.1
    UniProtKB/TrEMBL
    A0A0G2JLR5
    Related
    ENSP00000380712.3, ENST00000397582.7
    Conserved Domains (1) summary
    smart00314
    Location:8 → 88
    RA; Ras association (RalGDS/AF-6) domain

  2. NM_001143994.2 → NP_001137466.1  ras association domain-containing protein 7 isoform 3

    See identical proteins and their annotated locations for NP_001137466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 3' coding region, compared to variant 1. This difference results in a frameshift and a protein (isoform 3) with a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AP006284, BC106921, BC106922, CA315057
    Consensus CDS
    CCDS44505.1
    UniProtKB/TrEMBL
    A0A0G2JLR5
    Related
    ENSP00000405606.2, ENST00000454668.2
    Conserved Domains (1) summary
    smart00314
    Location:8 → 88
    RA; Ras association (RalGDS/AF-6) domain

  3. NM_003475.4 → NP_003466.1  ras association domain-containing protein 7 isoform 1

    See identical proteins and their annotated locations for NP_003466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AP006284, BC106921, CA315057
    Consensus CDS
    CCDS7702.1
    UniProtKB/Swiss-Prot
    G5E9N9, Q02833, Q3KP41, Q3KP42
    UniProtKB/TrEMBL
    A0A0G2JMW4
    Related
    ENSP00000380713.3, ENST00000397583.8
    Conserved Domains (3) summary
    pfam00788
    Location:8 → 86
    RA; Ras association (RalGDS/AF-6) domain
    cl25363
    Location:123 → 199
    VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
    cl25732
    Location:177 → 294
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    560970..564025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    90626..93681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    607974..611029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02833.1 GenPept UniProtKB/Swiss-Prot:Q02833

Gene LinkOut

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