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Rabep2 rabaptin, RAB GTPase binding effector protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 80754, updated on 17-Aug-2024

Summary

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Official Symbol
Rabep2provided by RGD
Official Full Name
rabaptin, RAB GTPase binding effector protein 2provided by RGD
Primary source
RGD:621416
See related
EnsemblRapid:ENSRNOG00000018462 AllianceGenome:RGD:621416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fra; MP13
Summary
Predicted to enable GTPase activator activity and growth factor activity. Predicted to be involved in regulation of cilium assembly. Predicted to be located in centrosome; ciliary basal body; and cytosol. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human RABEP2 (rabaptin, RAB GTPase binding effector protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 135.3), Testes (RPKM 133.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rabep2 in Genome Data Viewer
Location:
1q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190433501..190457241)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181010305..181026651)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197839583..197855953)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36 like 3 Neighboring gene CD19 molecule Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene SH2B adaptor protein 1 Neighboring gene Tu translation elongation factor, mitochondrial

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin. Lerant AA, et al. Endocrine, 2001 Dec. PMID 11954661
  2. Cloning and expression of MP13 gene from rat hippocampus, a new factor related to guanosine triphosphate regulation. Feng Z, et al. Neurosci Lett, 2000 Dec 22. PMID 11108998
  3. Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration. Lerant A, et al. Brain Res, 2001 Jun 22. PMID 11406124
  4. Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts. Chang W, et al. J Biol Chem, 2004 Oct 8. PMID 15299028
  5. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. Airik R, et al. PLoS One, 2016. PMID 27224062, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fos-related antigen 2 has a role in controlling protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts
    Title: Fos-related antigen 2 controls protein kinase A-induced CCAAT/enhancer-binding protein beta expression in osteoblasts.
  2. effect of immunoneutralization of endogenous prolactin on expression of FRAs in the tuberoinfundibular dopaminergic, tuberohypophysial dopaminergic and periventricular hypothalamic dopaminergic subpopulations of the hypothalamic dopaminergic neurons
    Title: Decreased expression of fos-related antigens (FRAs) in the hypothalamic dopaminergic neurons after immunoneutralization of endogenous prolactin.
  3. Expression of Fos-related antigens is an indicator of neuronal activation in hypothalamic dopaminergic neurons after prolactin administration.
    Title: Nuclear translocation of STAT5 and increased expression of Fos related antigens (FRAs) in hypothalamic dopaminergic neurons after prolactin administration.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rab GTPase-binding effector protein 2
Names
Fos-related antigen
rabaptin-5beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030585.2 → NP_085074.2  rab GTPase-binding effector protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q62835
    UniProtKB/TrEMBL
    F1LQC4, Q5EBC7
    Related
    ENSRNOP00000025043.6, ENSRNOT00000025043.9
    Conserved Domains (2) summary
    pfam03528
    Location:26 → 168
    Rabaptin
    pfam09311
    Location:276 → 531
    Rab5-bind; Rabaptin-like protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    190433501..190457241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274956.1 → XP_063131026.1  rab GTPase-binding effector protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q62835
    UniProtKB/TrEMBL
    A6I951

  2. XM_039091811.2 → XP_038947739.1  rab GTPase-binding effector protein 2 isoform X2

    UniProtKB/TrEMBL
    A6I955
    Conserved Domains (1) summary
    pfam09311
    Location:131 → 386
    Rab5-bind; Rabaptin-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62835.1 GenPept UniProtKB/Swiss-Prot:Q62835

Gene LinkOut

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