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GRIP2 glutamate receptor interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 80852, updated on 7-Apr-2024

Summary

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Official Symbol
GRIP2provided by HGNC
Official Full Name
glutamate receptor interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:23841
See related
Ensembl:ENSG00000144596 AllianceGenome:HGNC:23841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart (RPKM 7.1), spleen (RPKM 5.7) and 21 other tissues See more
Orthologs
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Genomic context

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See GRIP2 in Genome Data Viewer
Location:
3p25.1
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (14489107..14603017, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (14491513..14605422, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (14530615..14581849, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14394065-14394622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14395183-14395740 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14395741-14396298 Neighboring gene long intergenic non-protein coding RNA 1267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14408879-14409397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14417978-14418496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14418497-14419013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14424454-14424979 Neighboring gene uncharacterized LOC105376959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14435811-14436550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14093 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19507 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14447712-14447882 Neighboring gene RNA, 5S ribosomal pseudogene 124 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:14451820-14453019 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14462886-14463709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14463710-14464532 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:14469801-14469955 Neighboring gene solute carrier family 6 member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14473371-14474282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14476107-14477018 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14477019-14477930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14480905-14481405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14492974-14493781 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14500879-14501379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14502387-14502908 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14501865-14502386 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14502909-14503430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14513531-14514422 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14537432-14537994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14539103-14539603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14546947-14547448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14547449-14547948 Neighboring gene Sharpr-MPRA regulatory region 227/3570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14555415-14555916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14559661-14560465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:14562934-14563775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14563776-14564616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14566631-14567132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14567133-14567632 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14573046-14573836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14573837-14574627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14577662-14578621 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14584584-14585084 Neighboring gene RNA, U6 small nuclear 905, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14589426-14589926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14605328-14605895 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14615395-14615896 Neighboring gene RHBDF1 pseudogene 1 Neighboring gene uncharacterized LOC105376960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14661555-14662054 Neighboring gene uncharacterized LOC124909347 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14692810-14693468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19515 Neighboring gene uncharacterized LOC124906215 Neighboring gene coiled-coil domain containing 174

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering. Lin SH, et al. Mol Pharmacol, 2001 Nov. PMID 11641419
  2. Novel anchorage of GluR2/3 to the postsynaptic density by the AMPA receptor-binding protein ABP. Srivastava S, et al. Neuron, 1998 Sep. PMID 9768844
  3. The proteoglycan NG2 is complexed with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by the PDZ glutamate receptor interaction protein (GRIP) in glial progenitor cells. Implications for glial-neuronal signaling. Stegmüller J, et al. J Biol Chem, 2003 Feb 7. PMID 12458226
  4. Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins. Ko J, et al. J Biol Chem, 2003 Oct 24. PMID 12923177
  5. PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Lu W, et al. Neuron, 2005 Aug 4. PMID 16055064

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in artery smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport in synapse IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in neuron spine IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate receptor-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080423.4 → NP_001073892.3  glutamate receptor-interacting protein 2

    See identical proteins and their annotated locations for NP_001073892.3

    Status: VALIDATED

    Source sequence(s)
    AB051506, AC090952, AK024507, AK095762
    Consensus CDS
    CCDS46766.2
    UniProtKB/Swiss-Prot
    A0A087WU38, Q8TEH9, Q9C0E4, Q9H7H3
    UniProtKB/TrEMBL
    A0A1B0GWJ3
    Related
    ENSP00000478352.1, ENST00000621039.5
    Conserved Domains (1) summary
    cd00992
    Location:655 → 735
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    14489107..14603017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449036.1 → XP_047304992.1  glutamate receptor-interacting protein 2 isoform X4

  2. XM_011534142.4 → XP_011532444.1  glutamate receptor-interacting protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A1B0GWJ3
    Conserved Domains (1) summary
    cd00992
    Location:660 → 740
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  3. XM_011534143.4 → XP_011532445.1  glutamate receptor-interacting protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A1B0GWJ3
    Conserved Domains (1) summary
    cd00992
    Location:620 → 700
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  4. XM_011534141.4 → XP_011532443.1  glutamate receptor-interacting protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWJ3
    Related
    ENSP00000490949.1, ENST00000637182.1
    Conserved Domains (1) summary
    cd00992
    Location:662 → 742
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  5. XM_011534146.4 → XP_011532448.1  glutamate receptor-interacting protein 2 isoform X7

    Conserved Domains (1) summary
    cd00992
    Location:408 → 488
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  6. XM_011534145.4 → XP_011532447.1  glutamate receptor-interacting protein 2 isoform X6

    Conserved Domains (1) summary
    cd00992
    Location:434 → 514
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  7. XM_047449037.1 → XP_047304993.1  glutamate receptor-interacting protein 2 isoform X5

  8. XM_047449038.1 → XP_047304994.1  glutamate receptor-interacting protein 2 isoform X8

  9. XM_047449040.1 → XP_047304996.1  glutamate receptor-interacting protein 2 isoform X9

RNA

  1. XR_007095752.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    14491513..14605422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348046.1 → XP_054204021.1  glutamate receptor-interacting protein 2 isoform X4

  2. XM_054348044.1 → XP_054204019.1  glutamate receptor-interacting protein 2 isoform X2

  3. XM_054348043.1 → XP_054204018.1  glutamate receptor-interacting protein 2 isoform X1

  4. XM_054348045.1 → XP_054204020.1  glutamate receptor-interacting protein 2 isoform X3

  5. XM_054348049.1 → XP_054204024.1  glutamate receptor-interacting protein 2 isoform X7

  6. XM_054348048.1 → XP_054204023.1  glutamate receptor-interacting protein 2 isoform X6

  7. XM_054348047.1 → XP_054204022.1  glutamate receptor-interacting protein 2 isoform X5

  8. XM_054348050.1 → XP_054204025.1  glutamate receptor-interacting protein 2 isoform X8

  9. XM_054348051.1 → XP_054204026.1  glutamate receptor-interacting protein 2 isoform X9

RNA

  1. XR_008486831.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0E4.4 GenPept UniProtKB/Swiss-Prot:Q9C0E4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous