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Ifitm2 interferon induced transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 80876, updated on 28-Oct-2024

Summary

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Official Symbol
Ifitm2provided by MGI
Official Full Name
interferon induced transmembrane protein 2provided by MGI
Primary source
MGI:MGI:1933382
See related
Ensembl:ENSMUSG00000060591 AllianceGenome:MGI:1933382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mil-3; DSPA2c; Ifitm3l; fragilis3
Summary
Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to virus. Predicted to be located in early endosome membrane; late endosome membrane; and lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including 4-cell stage embryo; brain; genitourinary system; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM2 (interferon induced transmembrane protein 2) and IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in ovary adult (RPKM 557.8), subcutaneous fat pad adult (RPKM 446.6) and 24 other tissues See more
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Genomic context

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See Ifitm2 in Genome Data Viewer
Location:
7 F5; 7 86.18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140534750..140539602, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (140954837..140959686, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2853 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148127673-148127984 Neighboring gene protein glucosylgalactosylhydroxylysine glucosidase Neighboring gene interferon induced transmembrane protein 5 Neighboring gene STARR-seq mESC enhancer starr_20461 Neighboring gene STARR-seq mESC enhancer starr_20462 Neighboring gene interferon induced transmembrane protein 1 Neighboring gene predicted gene 7514

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation. Yánez DC, et al. Eur J Immunol, 2019 Jan. PMID 30365177, Free PMC Article
  2. The Interferon-Stimulated Gene IFITM3 Restricts Infection and Pathogenesis of Arthritogenic and Encephalitic Alphaviruses. Poddar S, et al. J Virol, 2016 Oct 1. PMID 27440901, Free PMC Article
  3. Expression of the mouse fragilis gene products in immune cells and association with receptor signaling complexes. Smith RA, et al. Genes Immun, 2006 Mar. PMID 16395393
  4. Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells. Tanaka SS, et al. Mech Dev, 2002 Dec. PMID 14516695
  5. The C-terminal sequence of IFITM1 regulates its anti-HIV-1 activity. Jia R, et al. PLoS One, 2015. PMID 25738301, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that IFITM2 drives type 2 T helper cell differentiation and exacerbate allergic airway inflammation
    Title: IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102396

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cellular response to interferon-beta ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-alpha IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to type II interferon IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
interferon-induced transmembrane protein 2
Names
dispanin subfamily A member 2c
fragilis R
fragilis protein 3
interferon induced transmembrane protein, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030694.2 → NP_109619.1  interferon-induced transmembrane protein 2

    See identical proteins and their annotated locations for NP_109619.1

    Status: VALIDATED

    Source sequence(s)
    AC162287
    Consensus CDS
    CCDS21994.1
    UniProtKB/Swiss-Prot
    Q3TIG4, Q99J93
    Related
    ENSMUSP00000071470.9, ENSMUST00000081649.10
    Conserved Domains (1) summary
    pfam04505
    Location:54 → 117
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140534750..140539602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153595.1 → XP_036009488.1  interferon-induced transmembrane protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TIG4, Q99J93
    Conserved Domains (1) summary
    pfam04505
    Location:54 → 117
    CD225; Interferon-induced transmembrane protein

  2. XM_030243121.2 → XP_030098981.1  interferon-induced transmembrane protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TIG4, Q99J93
    Conserved Domains (1) summary
    pfam04505
    Location:54 → 117
    CD225; Interferon-induced transmembrane protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J93.1 GenPept UniProtKB/Swiss-Prot:Q99J93

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