U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Maged2 MAGE family member D2 [ Mus musculus (house mouse) ]

Gene ID: 80884, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Maged2provided by MGI
Official Full Name
MAGE family member D2provided by MGI
Primary source
MGI:MGI:1933391
See related
Ensembl:ENSMUSG00000025268 AllianceGenome:MGI:1933391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORF1; Mage-d2; 4833439A22Rik
Summary
Predicted to be involved in female pregnancy; negative regulation of transcription by RNA polymerase II; and renal sodium ion absorption. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; branchial arch; egg cylinder; genitourinary system; and liver. Human ortholog(s) of this gene implicated in Bartter disease type 5. Orthologous to human MAGED2 (MAGE family member D2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in limb E14.5 (RPKM 115.6), placenta adult (RPKM 69.2) and 21 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Maged2 in Genome Data Viewer
Location:
X F3; X 68.46 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149589417..149597358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150806421..150814362, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 33991 Neighboring gene STARR-seq mESC enhancer starr_48071 Neighboring gene STARR-seq mESC enhancer starr_48072 Neighboring gene predicted gene, 18773 Neighboring gene predicted gene, 24907 Neighboring gene predicted gene, 54086 Neighboring gene inter-alpha-trypsin inhibitor heavy chain family member 6 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells. Valiño-Rivas L, et al. Nephrol Dial Transplant, 2019 Sep 1. PMID 30541139
  2. Molecular evolution of type II MAGE genes from ancestral MAGED2 gene and their phylogenetic resolution of basal mammalian clades. De Donato M, et al. Mamm Genome, 2017 Oct. PMID 28516231
  3. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues. Langnaese K, et al. Cytogenet Cell Genet, 2001. PMID 11856887
  4. Comparative expression analysis of the MAGED genes during embryogenesis and brain development. Bertrand M, et al. Dev Dyn, 2004 Jun. PMID 15162511
  5. Mammalian small nucleolar RNAs are mobile genetic elements. Weber MJ. PLoS Genet, 2006 Dec 8. PMID 17154719, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High MAGED2 expression is associated with tubular cell injury during kidney disease.
    Title: MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells.
  2. Maged2 is mainly expressed in tissues of mesodermal origin
    Title: Comparative expression analysis of the MAGED genes during embryogenesis and brain development.
  3. Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues
    Title: Expression pattern and further characterization of human MAGED2 and identification of rodent orthologues.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in female pregnancy ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in renal sodium ion absorption ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
melanoma-associated antigen D2
Names
melanoma antigen, family D, 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199246.2 → NP_001186175.1  melanoma-associated antigen D2

    See identical proteins and their annotated locations for NP_001186175.1

    Status: VALIDATED

    Source sequence(s)
    BB869272, BC058581
    Consensus CDS
    CCDS30466.1
    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Related
    ENSMUSP00000108320.2, ENSMUST00000112700.8
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

  2. NM_001358566.1 → NP_001345495.1  melanoma-associated antigen D2

    Status: VALIDATED

    Source sequence(s)
    AL672282
    Consensus CDS
    CCDS30466.1
    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

  3. NM_001358567.1 → NP_001345496.1  melanoma-associated antigen D2

    Status: VALIDATED

    Source sequence(s)
    AL672282
    Consensus CDS
    CCDS30466.1
    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

  4. NM_001358568.1 → NP_001345497.1  melanoma-associated antigen D2

    Status: VALIDATED

    Source sequence(s)
    AL672282
    Consensus CDS
    CCDS30466.1
    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Related
    ENSMUSP00000108317.4, ENSMUST00000112697.10
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

  5. NM_030700.3 → NP_109625.1  melanoma-associated antigen D2

    See identical proteins and their annotated locations for NP_109625.1

    Status: VALIDATED

    Source sequence(s)
    AJ277114, BP757994, CA752082
    Consensus CDS
    CCDS30466.1
    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Related
    ENSMUSP00000108319.3, ENSMUST00000112699.9
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    149589417..149597358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247882.2 → XP_011246184.1  melanoma-associated antigen D2 isoform X2

    See identical proteins and their annotated locations for XP_011246184.1

    UniProtKB/TrEMBL
    Q3TFU3, Q99PB4
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family

  2. XM_006528998.5 → XP_006529061.1  melanoma-associated antigen D2 isoform X1

    See identical proteins and their annotated locations for XP_006529061.1

    UniProtKB/TrEMBL
    Q3TFU3, Q9ER67
    Conserved Domains (3) summary
    PRK13335
    Location:32 → 125
    PRK13335; superantigen-like protein SSL3; Reviewed
    PRK13914
    Location:33 → 224
    PRK13914; invasion associated endopeptidase
    pfam01454
    Location:286 → 454
    MAGE; MAGE family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous