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Slco1a5 solute carrier organic anion transporter family, member 1A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 80900, updated on 2-Nov-2024

Summary

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Official Symbol
Slco1a5provided by RGD
Official Full Name
solute carrier organic anion transporter family, member 1A5provided by RGD
Primary source
RGD:70985
See related
EnsemblRapid:ENSRNOG00000086993 AllianceGenome:RGD:70985
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oatp3; OATP-3; Slc21a7; Slco1a2
Summary
Enables bile acid transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in animal organ regeneration; bile acid and bile salt transport; and intestinal absorption. Located in brush border membrane. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 22.0), Liver (RPKM 15.2) and 6 other tissues See more
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Genomic context

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See Slco1a5 in Genome Data Viewer
Location:
4q44
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (176903387..176985589, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (175172390..175254598, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176445856..176528117, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a8 Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene islet amyloid polypeptide Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5. Arakawa H, et al. Biopharm Drug Dispos, 2012 Sep. PMID 22899169
  2. Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats. Tani T, et al. Pharm Res, 2008 May. PMID 17957449
  3. Transporter-mediated intestinal absorption of fexofenadine in rats. Kikuchi A, et al. Drug Metab Pharmacokinet, 2006 Aug. PMID 16946558
  4. Expression and functional involvement of organic anion transporting polypeptide subtype 3 (Slc21a7) in rat choroid plexus. Kusuhara H, et al. Pharm Res, 2003 May. PMID 12751626
  5. In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Ohtsuki S, et al. Mol Pharmacol, 2003 Mar. PMID 12606759

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
    Title: Inflammation-Induced Attenuation of Prostaglandin D(2) Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
  2. The intestinal absorption of ciprofloxacin could be affected by influx transporters such as Oatp1a5.
    Title: Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.
  3. consistently suggested that Oatp1a5 is contributing to the intestinal absorption
    Title: Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.
  4. the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate.
    Title: In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate.
  5. Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
    Title: Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monocarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thyroid hormone transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in animal organ regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid and bile salt transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intestinal absorption IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monocarboxylic acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic anion transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thyroid hormone transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basal plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 1A5
Names
organic anion-transporting polypeptide 3
sodium-independent organic anion transporter 3
solute carrier family 21 (fatty acid transporter) member 7
solute carrier family 21 member 7
solute carrier organic anion transporter family, member 1A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030838.1 → NP_110465.1  solute carrier organic anion transporter family member 1A5

    See identical proteins and their annotated locations for NP_110465.1

    Status: PROVISIONAL

    Source sequence(s)
    AF083469
    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A0A8L2QP25, A6IMT1
    Related
    ENSRNOP00000015112.7, ENSRNOT00000015112.8
    Conserved Domains (3) summary
    cd06174
    Location:21 → 397
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:436 → 487
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    TIGR00805
    Location:1 → 625
    oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    176903387..176985589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286736.1 → XP_063142806.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1

  2. XM_063286732.1 → XP_063142802.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1

  3. XM_063286731.1 → XP_063142801.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1

  4. XM_063286734.1 → XP_063142804.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1

  5. XM_063286735.1 → XP_063142805.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1

  6. XM_063286733.1 → XP_063142803.1  solute carrier organic anion transporter family member 1A5 isoform X1

    UniProtKB/Swiss-Prot
    O88397, Q9EQR8
    UniProtKB/TrEMBL
    A6IMT1
    Related
    ENSRNOP00000048288.5, ENSRNOT00000049569.6

  7. XM_063286737.1 → XP_063142807.1  solute carrier organic anion transporter family member 1A5 isoform X2

RNA

  1. XR_010065708.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88397.2 GenPept UniProtKB/Swiss-Prot:O88397

Gene LinkOut

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