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Acox3 acyl-Coenzyme A oxidase 3, pristanoyl [ Mus musculus (house mouse) ]

Gene ID: 80911, updated on 2-Nov-2024

Summary

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Official Symbol
Acox3provided by MGI
Official Full Name
acyl-Coenzyme A oxidase 3, pristanoylprovided by MGI
Primary source
MGI:MGI:1933156
See related
Ensembl:ENSMUSG00000029098 AllianceGenome:MGI:1933156
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PCOX; EST-s59
Summary
Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase. Predicted to act upstream of or within fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including brain; colon; genitourinary system; heart; and lung. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 39.5), kidney adult (RPKM 13.1) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Acox3 in Genome Data Viewer
Location:
5 B3; 5 18.32 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35740293..35772397)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35582981..35614208)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12857 Neighboring gene carboxypeptidase Z Neighboring gene polo like kinase, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_12858 Neighboring gene tRNA methyltransferase 44 Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene HtrA serine peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene predicted gene, 31888

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain. Knoll A, et al. Neurosci Lett, 2000 May 19. PMID 10806321
  2. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Yubero P, et al. Endocrinology, 2004 Sep. PMID 15178647
  3. Spermatogonia-dependent expression of testicular genes in mice. Tanaka K, et al. Dev Biol, 2002 Jun 15. PMID 12051830
  4. Accumulation of NCOA1 dependent on HERC3 deficiency transactivates matrix metallopeptidases and promotes extracellular matrix degradation in intervertebral disc degeneration. Li X, et al. Life Sci, 2023 May 1. PMID 36878279
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid binding IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables pristanoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pristanoyl-CoA oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables pristanoyl-CoA oxidase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid beta-oxidation TAS
Traceable Author Statement
more info
 PubMed 
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal acyl-coenzyme A oxidase 3
Names
BRCACox
branched-chain acyl-CoA oxidase
pristanoyl-CoA oxidase
NP_001343947.1
NP_001343948.1
NP_001343949.1
NP_001412726.1
NP_109646.2
XP_006504259.1
XP_006504260.1
XP_006504262.1
XP_006504263.1
XP_011239103.1
XP_017176668.1
XP_036021519.1
XP_036021520.1
XP_036021521.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357018.2 → NP_001343947.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122871
    Consensus CDS
    CCDS19232.1
    UniProtKB/Swiss-Prot
    Q7TPP6, Q80UQ0, Q9EPL9
    UniProtKB/TrEMBL
    E9Q296
    Related
    ENSMUSP00000109875.2, ENSMUST00000114237.8
    Conserved Domains (1) summary
    cd01150
    Location:19 → 672
    AXO; Peroxisomal acyl-CoA oxidase

  2. NM_001357019.2 → NP_001343948.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122871
    Consensus CDS
    CCDS19232.1
    UniProtKB/Swiss-Prot
    Q7TPP6, Q80UQ0, Q9EPL9
    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 672
    AXO; Peroxisomal acyl-CoA oxidase

  3. NM_001357020.2 → NP_001343949.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC122871
    Consensus CDS
    CCDS89913.1
    UniProtKB/TrEMBL
    E9Q296, Q8C178
    Related
    ENSMUSP00000067178.6, ENSMUST00000068563.12
    Conserved Domains (1) summary
    cd01150
    Location:19 → 662
    AXO; Peroxisomal acyl-CoA oxidase

  4. NM_001425797.1 → NP_001412726.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longer isoform (a). Variants 1, 2, 3 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122871
    UniProtKB/Swiss-Prot
    Q7TPP6, Q80UQ0, Q9EPL9

  5. NM_030721.4 → NP_109646.2  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    See identical proteins and their annotated locations for NP_109646.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 3 and 5 all encode the same isoform (a).
    Source sequence(s)
    AC122871
    Consensus CDS
    CCDS19232.1
    UniProtKB/Swiss-Prot
    Q7TPP6, Q80UQ0, Q9EPL9
    UniProtKB/TrEMBL
    E9Q296
    Related
    ENSMUSP00000063412.8, ENSMUST00000068947.14
    Conserved Domains (1) summary
    cd01150
    Location:19 → 672
    AXO; Peroxisomal acyl-CoA oxidase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    35740293..35772397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504199.5 → XP_006504262.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

    See identical proteins and their annotated locations for XP_006504262.1

    UniProtKB/TrEMBL
    E9Q296, Q3TAW3
    Related
    ENSMUSP00000144499.2, ENSMUST00000202266.4
    Conserved Domains (1) summary
    cd01150
    Location:19 → 662
    AXO; Peroxisomal acyl-CoA oxidase

  2. XM_006504200.5 → XP_006504263.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X4

    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 661
    AXO; Peroxisomal acyl-CoA oxidase

  3. XM_017321179.3 → XP_017176668.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 663
    AXO; Peroxisomal acyl-CoA oxidase

  4. XM_006504197.5 → XP_006504260.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

    See identical proteins and their annotated locations for XP_006504260.1

    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 663
    AXO; Peroxisomal acyl-CoA oxidase

  5. XM_011240801.4 → XP_011239103.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

    See identical proteins and their annotated locations for XP_011239103.1

    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 663
    AXO; Peroxisomal acyl-CoA oxidase

  6. XM_006504196.5 → XP_006504259.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

    See identical proteins and their annotated locations for XP_006504259.1

    UniProtKB/TrEMBL
    E9Q296
    Conserved Domains (1) summary
    cd01150
    Location:19 → 663
    AXO; Peroxisomal acyl-CoA oxidase

  7. XM_036165628.1 → XP_036021521.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X6

    Conserved Domains (1) summary
    cl09933
    Location:1 → 359
    ACAD; Acyl-CoA dehydrogenase

  8. XM_036165627.1 → XP_036021520.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X5

    Conserved Domains (1) summary
    cl09933
    Location:1 → 350
    ACAD; Acyl-CoA dehydrogenase

  9. XM_036165626.1 → XP_036021519.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X5

    Conserved Domains (1) summary
    cl09933
    Location:1 → 350
    ACAD; Acyl-CoA dehydrogenase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EPL9.2 GenPept UniProtKB/Swiss-Prot:Q9EPL9

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