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ORC4 origin recognition complex subunit 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814641, updated on 18-Sep-2024

Summary

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Official Symbol
ORC4
Official Full Name
origin recognition complex subunit 4
Primary source
TAIR:AT2G01120
Locus tag
AT2G01120
See related
Araport:AT2G01120
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATORC4; F23H14.9; F23H14_9; origin recognition complex subunit 4; ORIGIN RECOGNITION COMPLEX SUBUNIT 4
Summary
Origin Recognition Complex subunit 4. Involved in the initiation of DNA replication. Regulated transcriptionally during cell cycle, peaking at G1/S-phase. Target of E2F/DF family of transcription factors. Interacts with all ORC subunits except ORC1b.
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Genomic context

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See ORC4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
16
Sequence:
Chromosome: 2; NC_003071.7 (85401..88399)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ubiquinol-cytochrome C reductase hinge protein Neighboring gene FAM133-like protein Neighboring gene Sec-independent periplasmic protein translocase Neighboring gene ncRNA Neighboring gene DEA(D/H)-box RNA helicase family protein Neighboring gene Aldolase superfamily protein Neighboring gene RING-H2 finger protein 2B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genes encoding Arabidopsis ORC subunits are E2F targets and the two ORC1 genes are differently expressed in proliferating and endoreplicating cells. Diaz-Trivino S, et al. Nucleic Acids Res, 2005. PMID 16179646, Free PMC Article
  2. ABAP1 is a novel plant Armadillo BTB protein involved in DNA replication and transcription. Masuda HP, et al. EMBO J, 2008 Oct 22. PMID 18818695, Free PMC Article
  3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001202564.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
part_of origin recognition complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
origin recognition complex subunit 4
NP_001189493.1
  • origin recognition complex subunit 4 (ORC4); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Origin recognition complex, subunit 4 (InterPro:IPR016527).
NP_178222.4
  • origin recognition complex subunit 4 (ORC4); CONTAINS InterPro DOMAIN/s: ATPase, AAA-type, core (InterPro:IPR003959), Origin recognition complex, subunit 4 (InterPro:IPR016527); Has 675 Blast hits to 668 proteins in 199 species: Archae - 9; Bacteria - 0; Metazoa - 335; Fungi - 166; Plants - 90; Viruses - 0; Other Eukaryotes - 75 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    85401..88399
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126174.5 → NP_178222.4  origin recognition complex subunit 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178222.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IM83, Q6E7G9, Q6EWX1, Q70BT4, Q9SJV4
    UniProtKB/TrEMBL
    A0A5S9WW79
    Conserved Domains (3) summary
    cd00009
    Location:53 → 205
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1474
    Location:33 → 257
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:217 → 392
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus

  2. NM_001202564.1 → NP_001189493.1  origin recognition complex subunit 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001189493.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IM83, Q6E7G9, Q6EWX1, Q70BT4, Q9SJV4
    UniProtKB/TrEMBL
    A0A5S9WW79, F4IM82
    Conserved Domains (3) summary
    cd00009
    Location:53 → 205
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    COG1474
    Location:33 → 257
    CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
    pfam14629
    Location:217 → 398
    ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus
Nucleotide Protein
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