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QPT quinolinate phoshoribosyltransferase [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814663, updated on 18-Sep-2024

Summary

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Official Symbol
QPT
Official Full Name
quinolinate phoshoribosyltransferase
Primary source
TAIR:AT2G01350
Locus tag
AT2G01350
See related
Araport:AT2G01350
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F10A8.23; F10A8_23; quinolinate phoshoribosyltransferase
Summary
At2g01350 encodes quinolinate phosphoribosyl transferase involved in NAD biosynthesis as shown by heterologous expression in E. coli.
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Genomic context

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See QPT in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (165141..167259, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ABC-2 type transporter family protein Neighboring gene nucleotide binding protein Neighboring gene plastid movement impaired protein Neighboring gene pentatricopeptide (PPR) repeat protein Neighboring gene DNA-binding storekeeper protein-related transcriptional regulator

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid. Katoh A, et al. Plant Physiol, 2006 Jul. PMID 16698895, Free PMC Article
  2. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
  3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084395.1
NM_001084396.1
NM_126196.3
NM_201664.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nicotinate-nucleotide diphosphorylase (carboxylating) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within NAD biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within NAD biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
quinolinate phoshoribosyltransferase
NP_001077864.1
  • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5825 Blast hits to 5825 proteins in 1916 species: Archae - 184; Bacteria - 3588; Metazoa - 59; Fungi - 124; Plants - 57; Viruses - 0; Other Eukaryotes - 1813 (source: NCBI BLink).
NP_001077865.1
  • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5862 Blast hits to 5862 proteins in 1918 species: Archae - 184; Bacteria - 3596; Metazoa - 59; Fungi - 124; Plants - 57; Viruses - 0; Other Eukaryotes - 1842 (source: NCBI BLink).
NP_565259.1
  • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 5853 Blast hits to 5853 proteins in 1914 species: Archae - 184; Bacteria - 3582; Metazoa - 59; Fungi - 129; Plants - 57; Viruses - 0; Other Eukaryotes - 1842 (source: NCBI BLink).
NP_973393.1
  • quinolinate phoshoribosyltransferase (QPT); FUNCTIONS IN: nicotinate-nucleotide diphosphorylase (carboxylating) activity; INVOLVED IN: NAD biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), Nicotinate-nucleotide pyrophosphorylase (InterPro:IPR004393), Quinolinate phosphoribosyl transferase, N-terminal (InterPro:IPR022412), Quinolinate phosphoribosyl transferase, C-terminal domain (InterPro:IPR002638); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    165141..167259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126196.3 → NP_565259.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565259.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LC11, Q93ZA4, Q9ZU32
    UniProtKB/TrEMBL
    A0A178VX18, A0A5S9WWD9, A0A7G2E7G9
    Conserved Domains (1) summary
    PLN02716
    Location:29 → 336
    PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)

  2. NM_001084395.1 → NP_001077864.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077864.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2E7G9, A8MRX1
    Conserved Domains (2) summary
    PLN02716
    Location:29 → 330
    PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)
    cd01572
    Location:48 → 326
    QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...

  3. NM_201664.2 → NP_973393.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973393.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4INA0
    Conserved Domains (2) summary
    cd01572
    Location:1 → 265
    QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
    TIGR00078
    Location:2 → 266
    nadC; nicotinate-nucleotide pyrophosphorylase

  4. NM_001084396.1 → NP_001077865.1  quinolinate phoshoribosyltransferase [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077865.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2E7G9, A8MS71
    Conserved Domains (2) summary
    PLN02716
    Location:8 → 315
    PLN02716; nicotinate-nucleotide diphosphorylase (carboxylating)
    cd01572
    Location:27 → 311
    QPRTase; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZU32.2

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