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PIN4 Auxin efflux carrier family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814670, updated on 18-Sep-2024

Summary

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Official Symbol
PIN4
Official Full Name
Auxin efflux carrier family protein
Primary source
TAIR:AT2G01420
Locus tag
AT2G01420
See related
Araport:AT2G01420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS PIN-FORMED 4; ATPIN4; AUXIN TRANSPORTER SPLICE VARIANT B; F10A8.27; PIN-FORMED 4
Summary
Encodes a putative auxin efflux carrier that is localized in developing and mature root meristems. It is involved in the maintenance of embryonic auxin gradients. A role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning is proposed. In the root, PIN4 is detected around the quiescent center and cells surrounding it, and localizes basally in provascular cells. PIN4 expression is upregulated in brassinosteroid-insensitive mutant (PMID 16141452).
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Genomic context

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See PIN4 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Sequence:
Chromosome: 2; NC_003071.7 (180033..183764, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NHL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene homeobox-leucine zipper protein 17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis. Friml J, et al. Cell, 2002 Mar 8. PMID 11893337
  2. Maintenance of embryonic auxin distribution for apical-basal patterning by PIN-FORMED-dependent auxin transport in Arabidopsis. Weijers D, et al. Plant Cell, 2005 Sep. PMID 16055631, Free PMC Article
  3. The PIN auxin efflux facilitator network controls growth and patterning in Arabidopsis roots. Blilou I, et al. Nature, 2005 Jan 6. PMID 15635403
  4. Cytokinin Targets Auxin Transport to Promote Shoot Branching. Waldie T, et al. Plant Physiol, 2018 Jun. PMID 29717021, Free PMC Article
  5. Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux. Michniewicz M, et al. Cell, 2007 Sep 21. PMID 17889649

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIN4 role in shoot branching.
    Title: Cytokinin Targets Auxin Transport to Promote Shoot Branching.
  2. ABA treatment reduced the expression levels of the PIN-FORMEDs (PIN) auxin efflux carriers, PIN1, PIN3, PIN4, and PIN7, to a greater extent in the root meristems of arf2-101 mutant than in the wild type. ARF2 positively mediates the transcripts of transcription factor PLETHORA 1 (PLT1) gene but negatively mediates PLT2 at protein level in root meristems.
    Title: ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis .
  3. Functional interplay between protein kinase CK2 and salicylic acid sustains PIN4 transcriptional expression.
    Title: Functional interplay between protein kinase CK2 and salicylic acid sustains PIN transcriptional expression and root development.
  4. Data show that phototropic hypocotyl bending is strongly dependent on the activity of D6PKs and the PIN-FORMED (PIN) auxin efflux facilitators PIN3, PIN4, and PIN7.
    Title: D6PK AGCVIII kinases are required for auxin transport and phototropic hypocotyl bending in Arabidopsis.
  5. NOV is required for cell type-specific expression of PIN4 in the root.
    Title: NO VEIN mediates auxin-dependent specification and patterning in the Arabidopsis embryo, shoot, and root.
  6. PP2A and PINOID both partially colocalize with PINs and act antagonistically on the phosphorylation state of their central hydrophilic loop, hence mediating PIN apical-basal polar targeting.
    Title: Antagonistic regulation of PIN phosphorylation by PP2A and PINOID directs auxin flux.
  7. Data suggest that auxin transport activity, in particular that of the PIN-FORMED1 (PIN1) and PIN4 proteins, is a major factor in the maintenance of auxin gradients.
    Title: Maintenance of embryonic auxin distribution for apical-basal patterning by PIN-FORMED-dependent auxin transport in Arabidopsis.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

NM_001335061.1
NM_126203.3
NM_179592.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables auxin efflux transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in auxin export across the plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within auxin polar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Auxin efflux carrier family protein
NP_565261.1
  • PIN-FORMED 4 (PIN4); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: root development, pattern specification process, auxin polar transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 1811 Blast hits to 1602 proteins in 498 species: Archae - 31; Bacteria - 1046; Metazoa - 12; Fungi - 10; Plants - 485; Viruses - 0; Other Eukaryotes - 227 (source: NCBI BLink).
NP_849923.1
  • PIN-FORMED 4 (PIN4); FUNCTIONS IN: auxin:hydrogen symporter activity, transporter activity; INVOLVED IN: root development, pattern specification process, auxin polar transport; LOCATED IN: endomembrane system, integral to membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Auxin efflux carrier, subgroup (InterPro:IPR014024), Auxin efflux carrier (InterPro:IPR004776); BEST Arabidopsis thaliana protein match is: Auxin efflux carrier family protein (TAIR:AT1G70940.1); Has 1823 Blast hits to 1616 proteins in 502 species: Archae - 31; Bacteria - 1046; Metazoa - 18; Fungi - 10; Plants - 487; Viruses - 2; Other Eukaryotes - 229 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    180033..183764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126203.3 → NP_565261.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565261.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9WWA4, A0A654ER02
    Conserved Domains (1) summary
    pfam03547
    Location:451 → 607
    Mem_trans; Membrane transport protein

  2. NM_179592.2 → NP_849923.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_849923.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RWZ6, Q9M7Q6, Q9MAS3
    UniProtKB/TrEMBL
    A0A178VZS2, A0A5S9WWA4, A0A654ER02
    Conserved Domains (1) summary
    pfam03547
    Location:455 → 611
    Mem_trans; Membrane transport protein

  3. NM_001335061.1 → NP_001323732.1  Auxin efflux carrier family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178W185, A0A1P8AY30
    Conserved Domains (2) summary
    pfam03547
    Location:9 → 190
    Mem_trans; Membrane transport protein
    cl22894
    Location:455 → 517
    Mem_trans; Membrane transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8RWZ6.1

Gene LinkOut

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