RGA1 GRAS family transcription factor family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RGA1
Official Full Name: GRAS family transcription factor family protein
Primary source: TAIR:AT2G01570
Locus tag: AT2G01570
See related: Araport:AT2G01570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F2I9.19; F2I9_19; REPRESSOR OF GA; REPRESSOR OF GA1-3 1; RGA
Summary: Member of the VHIID/DELLA regulatory family. Contains homopolymeric serine and threonine residues, a putative nuclear localization signal, leucine heptad repeats, and an LXXLL motif. Putative transcriptional regulator repressing the gibberellin response and integration of phytohormone signalling. DELLAs repress cell proliferation and expansion that drives plant growth. The protein undergoes degradation in response to GA via the 26S proteasome. RGA1 binds to PIF3 and inhibits its DNA binding activity and thus affects the expression of PIF3 regulated genes. RGA may be involved in reducing ROS accumulation in response to stress by up-regulating the transcription of superoxide dismutases. Represses GA-induced vegetative growth and floral initiation. Rapidly degraded in response to GA. Involved in fruit and flower development.
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Genomic context

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See RGA1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (255247..257568, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.
Title: Gibberellin Signaling through RGA Suppresses GCN5 Effects on Arabidopsis Developmental Stages.
MLK1/2 and RGA directly interact with CIRCADIAN CLOCK ASSOCIATED1 (CCA1), which targets the promoter of DWARF4 (DWF4) to regulate its roles in cell expansion.
Title: MLK1 and MLK2 Coordinate RGA and CCA1 Activity to Regulate Hypocotyl Elongation in Arabidopsis thaliana.
RGA negatively regulate dark-induced senescence and chlorophyll degradation.RGA physically interacts with WRKY6.
Title: DELLA proteins negatively regulate dark-induced senescence and chlorophyll degradation in Arabidopsis through interaction with the transcription factor WRKY6.
The six conserved Ser/Thr sites are important for the different bioactivities of the RGA protein that regulate the gibberellin (GA) response, and also for RGA stability via the mimicking of phosphorylation/de-phosphorylation.
Title: The six conserved serine/threonine sites of REPRESSOR OF ga1-3 protein are important for its functionality and stability in gibberellin signaling in Arabidopsis.
RGA and GAI play distinct roles in seed germination.
Title: Independent and interactive effects of DOF affecting germination 1 (DAG1) and the Della proteins GA insensitive (GAI) and Repressor of ga1-3 (RGA) in embryo development and seed germination.
DELLA activity is essential for Arabidopsis pollen development.
Title: DELLA activity is required for successful pollen development in the Columbia ecotype of Arabidopsis.
Data indicate that BZR1 interacts in vitro and in vivo with REPRESSOR OF ga1-3 (RGA), a member of the DELLA family of transcriptional regulators that inhibits the gibberellins (GAs) signaling pathway.
Title: An interaction between BZR1 and DELLAs mediates direct signaling crosstalk between brassinosteroids and gibberellins in Arabidopsis.
RGA represses flowering in leaves through FT and miR172 under long-day conditions, and represses flowering at the shoot apex through MADS box genes.
Title: Gibberellin regulates the Arabidopsis floral transition through miR156-targeted SQUAMOSA promoter binding-like transcription factors.
Studies indicate that GRAS proteins are named after the first three members: GIBBERELLIC ACID INSENSITIVE (GAI), REPRESSOR of GAI (RGA) and SCARECROW (SCR), and they have diverse roles in plant development and signal transduction.
Title: A functionally required unfoldome from the plant kingdom: intrinsically disordered N-terminal domains of GRAS proteins are involved in molecular recognition during plant development.
SPT acts in an analogous manner to the gibberellin-dependent DELLAs, REPRESSOR OF GA1-3 and GIBBERELLIC ACID INSENSITIVE, which restrain cotyledon expansion alongside SPT.
Title: A DELLA in disguise: SPATULA restrains the growth of the developing Arabidopsis seedling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MASC_STS15662 (e-PCR)
- UniSTS:258817

NM_126218.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within gibberellic acid mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within hyperosmotic salinity response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within meiotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gibberellic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of seed germination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of seed dormancy process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of seed dormancy process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of seed germination	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of seed germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cold	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ethylene	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to far red light	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: GRAS family transcription factor family protein

NP_178266.1

REPRESSOR OF GA1-3 1 (RGA1); CONTAINS InterPro DOMAIN/s: Transcriptional factor DELLA, N-terminal (InterPro:IPR021914), Transcription factor GRAS (InterPro:IPR005202); BEST Arabidopsis thaliana protein match is: GRAS family transcription factor family protein (TAIR:AT1G14920.1); Has 2724 Blast hits to 2666 proteins in 317 species: Archae - 0; Bacteria - 6; Metazoa - 0; Fungi - 4; Plants - 2709; Viruses - 0; Other Eukaryotes - 5 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

255247..257568 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126218.3 → NP_178266.1 GRAS family transcription factor family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178266.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O23642, O23725, Q941D4, Q9SLH3

UniProtKB/TrEMBL

A0A654ESG7

Conserved Domains (2) summary

pfam03514
Location:221 → 581

GRAS; GRAS domain family

pfam12041
Location:44 → 111

DELLA; Transcriptional regulator DELLA protein N terminal