RND2 Rho family GTPase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RND2provided by HGNC
Official Full Name: Rho family GTPase 2provided by HGNC
Primary source: HGNC:HGNC:18315
See related: Ensembl:ENSG00000108830 MIM:601555; AllianceGenome:HGNC:18315
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARHN; RHO7; RhoN
Summary: This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
Expression: Biased expression in brain (RPKM 14.7), testis (RPKM 13.8) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (43025231..43032041)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (43883786..43890596)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (41177248..41184058)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Title: RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Rho7 expression was increased in the neurons of patients with IE compared with control samples, which indicated that Rho7 may be associated with the progression of IE or act as a potential target for IE treatment.
Title: Upregulation of Rho7 in the temporal lobe tissue of humans with intractable epilepsy.
Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling
Title: Pragmin, a novel effector of Rnd2 GTPase, stimulates RhoA activity.
The RND2 mRNA levels increased significantly after gestation in myometria.
Title: Differences in the gestational pattern of mRNA expression of the Rnd family in rat and human myometria.
Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers
Title: Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

MARC_7249-7250:996687691:1 (e-PCR)
- UniSTS:269749

NoName (e-PCR)
- UniSTS:486353

RH98686 (e-PCR)
- UniSTS:92889

SHGC-30296 (e-PCR)
- UniSTS:63729

RH69062 (e-PCR)
- UniSTS:26610

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collateral sprouting	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: rho-related GTP-binding protein RhoN

Names: CTD-3199J23.4; GTP-binding protein Rho7; ras homolog gene family, member N; rho-related GTP-binding protein Rho7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005440.5 → NP_005431.1 rho-related GTP-binding protein RhoN

See identical proteins and their annotated locations for NP_005431.1

Status: REVIEWED

Source sequence(s)

AC135721, BC094842, BU687800, DB502558

Consensus CDS

CCDS11452.1

UniProtKB/Swiss-Prot

A8K2D4, O00690, O00734, P52198, Q5U0P6, Q99535

UniProtKB/TrEMBL

Q59EN3

Related

ENSP00000466680.1, ENST00000587250.4

Conserved Domains (1) summary

cd04173
Location:7 → 227

Rnd2_Rho7; Rnd2/Rho7 GTPases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

43025231..43032041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525316.2 → XP_011523618.1 rho-related GTP-binding protein RhoN isoform X1

See identical proteins and their annotated locations for XP_011523618.1

UniProtKB/TrEMBL

Q59EN3

Conserved Domains (2) summary

smart00174
Location:10 → 182

RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

cd04173
Location:7 → 227

Rnd2_Rho7; Rnd2/Rho7 GTPases
XM_011525317.3 → XP_011523619.1 rho-related GTP-binding protein RhoN isoform X2

See identical proteins and their annotated locations for XP_011523619.1

UniProtKB/TrEMBL

Q59EN3

Conserved Domains (1) summary

cl38936
Location:7 → 199

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases