PDRG1 p53 and DNA damage regulated 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PDRG1provided by HGNC
Official Full Name: p53 and DNA damage regulated 1provided by HGNC
Primary source: HGNC:HGNC:16119
See related: Ensembl:ENSG00000088356 MIM:610789; AllianceGenome:HGNC:16119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PDRG; C20orf126
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytoplasm. Predicted to be part of prefoldin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis (RPKM 24.8), placenta (RPKM 9.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 20q11.21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (31944337..31952046, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (33668974..33676683, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (30532140..30539849, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDRG1 promotes the proliferation and migration of GBM cells by the MEK/ERK/CD44 pathway.
Title: PDRG1 promotes the proliferation and migration of GBM cells by the MEK/ERK/CD44 pathway.
PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
Title: PDRG1 predicts a poor prognosis and facilitates the proliferation and metastasis of colorectal cancer.
PDRG1 association with the Wnt signaling pathway in esophageal cancer cells.PDRG1 may promote proliferation while inhibiting apoptosis and chemotherapy sensitivity in esophageal cancer cells.
Title: Knockdown of PDRG1 Could Inhibit the Wnt Signaling Pathway in Esophageal Cancer Cells.
Specific PDRG1 gene silencing may inhibit the growth and metastasis of gastric cancer cells through the activation of ATM/p53 pathway.
Title: PDRG1 gene silencing contributes to inhibit the growth and induce apoptosis of gastric cancer cells.
It was found that PDRG1 could promote radio-resistance that involved the ATM-p53 signaling pathway in lung cancer cells.
Title: The PDRG1 is an oncogene in lung cancer cells, promoting radioresistance via the ATM-P53 signaling pathway.
PDRG1 expression is increased in multiple human malignancies suggesting it to be a high-value novel tumor marker that could play a role in cancer development and/or progression.
Title: PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress.
Is part of an RNA polymerase II-associated complex with possible chaperone activity.
Title: High-resolution mapping of the protein interaction network for the human transcription machinery and affinity purification of RNA polymerase II-associated complexes.
Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation
Title: Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Z94502 (e-PCR)
- UniSTS:70719

WI-13573 (e-PCR)
- UniSTS:49554

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of prefoldin complex	IEA Inferred from Electronic Annotation more info
part_of protein folding chaperone complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: p53 and DNA damage-regulated protein 1

Names: epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030815.3 → NP_110442.1 p53 and DNA damage-regulated protein 1

See identical proteins and their annotated locations for NP_110442.1

Status: VALIDATED

Source sequence(s)

AL031658, AY286301, BC009334, BM679702

Consensus CDS

CCDS13194.1

UniProtKB/Swiss-Prot

B2R511, Q96GP3, Q9BUW8, Q9NUG6

UniProtKB/TrEMBL

A0A384NKN4

Related

ENSP00000202017.4, ENST00000202017.6

Conserved Domains (1) summary

cl09111
Location:27 → 108

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...